Results 131 to 140 of about 5,972 (292)
Advanced Science, EarlyView.In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu +16 more
wiley +1 more source
Potential Immunohistochemical Biomarkers for Grading Oral Dysplasia: A Literature Review
BiomedicinesOral cancer is a prevalent global health issue, with significant morbidity and mortality rates. Despite available preventive measures, it remains one of the most common cancers, emphasising the need for improved diagnostic and prognostic tools.
Jakub Zdrojewski +7 more
doaj +1 more source
Caveolin-1 opens endothelial cell junctions by targeting catenins
, 2017 Aims A fundamental phenomenon in inflammation is the loss of endothelial barrier function, in which the opening of endothelial cell junctions plays a central role.
Seebach, Jochen +10 more
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Reduced gene expression of E-cadherin and associated catenins in human cervical carcinoma cell lines
Cell-cell adhesion mediated by E-cadherin is often lost or disturbed in human carcinomas. For regular adhesive function, E-cadherin has to form complexes with peripheral cytoplasmic catenins which are multifunctional proteins that are also involved in ...
Schwarz, E., Denk, C., Huelsken, J.
core +1 more source
Advanced Science, EarlyView.IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng +7 more
wiley +1 more source
The Role of Cadherins and Catenins in the Segregation and Migration of Spinal Motor Neurons [PDF]
, 2013 During development Spinal motor neurons are generated from their point of origin in the ventricular zone and migrate to reach their final settling position (motor pools) in the ventral spinal cord.
Bello, SM
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Advanced Science, EarlyView.This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong +6 more
wiley +1 more source
Advanced Science, EarlyView.ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang +9 more
wiley +1 more source
[原著］Distribution of Reduced Expression of E-Cadherin and Catenins in Squamous Cell Carcinoma of the Tongue with Special Reference to Its Clinical Significance [PDF]
The biologic aggressiveness of squamous cell carcinoma of the tongue is reflected in its ability to metastasize to cervical lymph nodes. Aberrant expression of E-cadherin and/or catenins is known to be associated with invasiveness and metastasis in a ...
Sunakawa, Hajime +3 more
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Three novel human sporadic melanoma cell lines: signaling pathways controlled by MC1R, BRAF and β-catenins [PDF]
, 2013 We studied the behaviour of three novel human sporadic melanoma cell lines (hmel1, hmel9, hmel11) extracted from tumors with different degrees of malignancy, concerning the cell signalling pathways controlled by MC1R, BRAF, NRAS and β-catenins. The novel
Turpin Sevilla, M. C. +14 more
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