Results 141 to 150 of about 6,280 (288)
Advanced Science, EarlyView.Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo +10 more
wiley +1 more source
Beta-Catenin Versus the Other Armadillo Catenins [PDF]
, 2013 Rachel K. Miller +3 more
openaire +1 more source
, 2013 We studied the behaviour of three novel human sporadic melanoma cell lines (hmel1, hmel9, hmel11), having different degree of malignancy, for cell signalling pathways controlled by MC1R, BRAF,NRAS and beta-catenins.
Zanna P. +9 more
core
Involvement of α- and ß-catenins and E-cadherin in the development of mammary phyllodes tumours
, 2012 Aims: Phyllodes tumours (PT) are rare but clinically important fibroepithelial tumours of the breast. beta-Catenin, a key component in Wnt signalling, has been shown to be important in the development of PT.
Tsang, Julia Y. +9 more
core +1 more source
Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders
Advanced Science, EarlyView.BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley +1 more source
Advanced Science, EarlyView.Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng +13 more
wiley +1 more source
Advanced Science, EarlyView.Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang +12 more
wiley +1 more source
Advanced Science, EarlyView.This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu +10 more
wiley +1 more source
[原著］Distribution of Reduced Expression of E-Cadherin and Catenins in Squamous Cell Carcinoma of the Tongue with Special Reference to Its Clinical Significance [PDF]
The biologic aggressiveness of squamous cell carcinoma of the tongue is reflected in its ability to metastasize to cervical lymph nodes. Aberrant expression of E-cadherin and/or catenins is known to be associated with invasiveness and metastasis in a ...
Sunakawa, Hajime +3 more
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