Results 121 to 130 of about 6,280 (288)
Advanced Science, EarlyView.Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh +22 more
wiley +1 more source
Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes
, 1996 The Wnt-1 proto-oncogene induces the accumulation of b-catenin and plakoglobin, two related proteins that associate with and functionally modulate the cadherin cell adhesion proteins. Here we have investigated the effects of Wnt-1 expression on the tumor
Bonnee Rubinfeld +3 more
core
Caveolin-1 opens endothelial cell junctions by targeting catenins [PDF]
, 2017 Aims A fundamental phenomenon in inflammation is the loss of endothelial barrier function, in which the opening of endothelial cell junctions plays a central role.
Seebach, Jochen +10 more
core
Cadherins, catenins and APC in pleural malignant mesothelioma
, 2003 Malignant mesothelioma is an aggressive disease of the pleura, and less commonly the peritoneum, with a very poor prognosis. The present study has examined the expression of cell adhesion molecules including cadherins, catenins, and APC in order to ...
Collins, J.E. +5 more
core +1 more source
Advanced Science, EarlyView.Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan +13 more
wiley +1 more source
, 2012 The presence of lymph node metastases is one of the most important prognostic indicators in head and neck squamous cell carcinomas (HNSCCs). An alteration of the E-cadherin-catenins complex and EGFR is essential for the invasiveness of cancer cells ...
Laura Marzocchella +33 more
core +1 more source
Advanced Science, EarlyView.The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan +10 more
wiley +1 more source
Role of Catenins in the Development of Gap Junctions in Rat Cardiomyocytes
, 2008 Gap junctions are intercellular communicating channels responsible for the synchronized activity of cardiomyocytes. Recent studies have shown that the membrane-associated guanylate kinase protein, zonula occludens-1 (ZO-1) can bind to catenins in ...
WU, JIAHN-CHUN;TSAI, RU-YIN;CHUNG, TUN- HUI +1 more
core
Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury
Advanced Science, EarlyView.Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang +14 more
wiley +1 more source
Potential Immunohistochemical Biomarkers for Grading Oral Dysplasia: A Literature Review
BiomedicinesOral cancer is a prevalent global health issue, with significant morbidity and mortality rates. Despite available preventive measures, it remains one of the most common cancers, emphasising the need for improved diagnostic and prognostic tools.
Jakub Zdrojewski +7 more
doaj +1 more source