Results 101 to 110 of about 5,972 (292)

Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes

, 1996
The Wnt-1 proto-oncogene induces the accumulation of b-catenin and plakoglobin, two related proteins that associate with and functionally modulate the cadherin cell adhesion proteins. Here we have investigated the effects of Wnt-1 expression on the tumor
Bonnee Rubinfeld, Paul Polakis, Brian Schryver, Jackie Papkoff   +3 more
core  

Caveolin-1 overexpression is associated with simultaneous abnormal expression of the E-cadherin/α-β catenins complex and multiple ErbB receptors and with lymph nodes metastasis in head and neck squamous cell carcinomas

, 2012
The presence of lymph node metastases is one of the most important prognostic indicators in head and neck squamous cell carcinomas (HNSCCs). An alteration of the E-cadherin-catenins complex and EGFR is essential for the invasiveness of cancer cells ...
Laura Marzocchella, Di Gennaro, E, Losito, S, Florigio Lista, MARZOCCHELLA, LAURA, Budillon, A, Domenico Vitolo, Roberto Bei, Masuelli, L, Alfredo Budillon, Lista, F, Patrizio Sale, Mrozek, M, Andrea Modesti, Sale, P, Longo, F, Franco Ionna, MODESTI, ANDREA, VITOLO, Domenico, Vitolo, D, Bei, R, Marie Agnes Mrozek, BEI, ROBERTO, MASUELLI, Laura, Marzocchella, L, Ionna, F, Muraro, R, Laura Masuelli, Modesti, A, Elena Di Gennaro, Marie‐Agnes Mrozek, Simona Losito, Francesco Longo, Raffaella Muraro   +33 more
core   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

The Role of Epithelial and Vascular-Endothelial Cadherin in the Differentiation and Maintance of Tissue Integrity

Acta Medica, 2001
The present review has focused on the cell adhesion molecules from the cadherin superfamily, in particular on E- and VE-cadherin. In general, cadherins are a large group of cell adhesion molecules located at intercellular junctions called adherent ...
Petr Nachtigal, Andrea Gojová, Vladimír Semecký   +2 more
doaj   +1 more source

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell-cell junctions during neural tube formation. [PDF]

Dev Dyn
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Thomas D, Hufft-Martinez BM, Lalwani Z, Pham V, Elmeniawi M, Tran AJ, Xu J, Saadi I, Fakhouri WD.   +8 more
europepmc   +2 more sources

Cadherin2/4-signaling via PTP1B and catenins is critical for nucleokinesis during radial neuronal migration in the neocortex

, 2016
Cadherins are critical for the radial migration of excitatory projection neurons into the developing neocortical wall. However, the specific cadherins and the signaling pathways that regulate radial migration are not well understood.
Gil-Sanz, C, Espinosa, A, Martinez-Garay, Isabel, Molnár, Zoltan, Mueller, U, Molnár, Z, Gil-Sanz, Cristina, Franco, Santos J., Mueller, Ulrich, Espinosa, Ana, Franco, SJ, Martinez-Garay, I   +11 more
core   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Expression of E-Cadherin, N-Cadherin, γ, β and α-Catenins in response to glucose for 24

, 2014
hrs. (A) The graph (left) shows real time PCR results for the positive expression of E-cadherin in MCF-7 and BT-474 cell lines; the grey and black bars represent two repeated independent experiments.
Sumaya Habib (662527), Mansour S. Al Moundhri (662528), Sirin A. I. Adham (662525), Hasina Al Rawahi (662526), Brenda L. Coomber (291277), Alicia Viloria-Petit (662529)   +5 more
core   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Endothelial Pim3 kinase protects the vascular barrier during lung metastasis

Nature Communications
Endothelial cells (ECs) form a tissue-specific barrier for disseminating cancer cells in distant organs. However, the molecular regulation of the ECs in the metastatic niche remains unclear.
Niina M. Santio, Keerthana Ganesh, Pihla P. Kaipainen, Aleksi Halme, Fatemeh Seyednasrollah, Emad Arbash, Satu Hänninen, Riikka Kivelä, Olli Carpen, Pipsa Saharinen   +9 more
doaj   +1 more source