Results 81 to 90 of about 83,980 (287)

Phosphorylation Reduces the Mechanical Stability of the α‐Catenin/ β‐Catenin Complex [PDF]

Angewandte Chemie International Edition, 2019
AbstractThe α‐catenin/β‐catenin complex serves as a critical molecular interface involved in cadherin–catenin‐based mechanosensing at the cell–cell adherence junction that plays a critical role in tissue integrity, repair, and embryonic development.
Shimin Le, Miao Yu, Jie Yan
openaire   +3 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Ctnna3 Deficiency Promotes Heart Regeneration by Enhancing Cardiomyocyte Proliferation in Neonatal Mice

Frontiers in Bioscience-Landmark
Background: Heart regeneration requires renewal of lost cardiomyocytes. However, the mammalian heart loses its proliferative capacity soon after birth, and the molecular signaling underlying the loss of cardiac proliferation ...
Sha Zou, Wuhou Dai, Wufan Tao, Jifen Li, Zeyi Cheng, Hongyan Wang   +5 more
doaj   +1 more source

SDF-1 alone and in co-operation with HGF regulates biology of human cervical carcinoma cells.

Folia Histochemica et Cytobiologica, 2006
Stromal Derived Factor-1 (SDF-1)-CXCR4 axis plays a pivotal role in biology and metastasis of several tumors. The aim of this study was to see if SDF-1 alone or in combination with Hepatocyte Growth Factor (HGF) affects biology of human cervical ...
Alfred B Jenson, Marcin Wysoczynski, Ewa Lesko, Justyna Drukala, Marcin Majka, Mariusz Z Ratajczak   +5 more
doaj   +1 more source

Heparanase Loosens E-Cadherin-Mediated Cell-Cell Contact via Activation of Src

Frontiers in Oncology, 2020
Activity of heparanase, responsible for cleavage of heparan sulfate (HS), is strongly implicated in tumor metastasis. This is due primarily to remodeling of the extracellular matrix (ECM) that becomes more prone to invasion by metastatic tumor cells.
Victoria Cohen-Kaplan, Neta Ilan, Israel Vlodavsky   +2 more
doaj   +1 more source

In Vitro Degradation of Endothelial Catenins by a Neutrophil Protease

Journal of Cell Biology, 1998
It has been recently proposed that adhesion of polymorphonuclear cells (PMNs) to human umbilical vein endothelial cells leads to the disorganization of the vascular endothelial cadherin–dependent endothelial adherens junctions.
T. Moll, E. Dejana, D. Vestweber
semanticscholar   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Pre-metazoan origins and evolution of the cadherin adhesome

Biology Open, 2014
Vertebrate adherens junctions mediate cell–cell adhesion via a “classical” cadherin–catenin “core” complex, which is associated with and regulated by a functional network of proteins, collectively named the cadherin adhesome (“cadhesome”). The most basal
Paul S. Murray, Ronen Zaidel-Bar
doaj   +1 more source

ECCU (E-cadherin/catenin) complex and its role in carcinogenesis

Journal of Education, Health and Sport, 2020
Introduction:One of the main characteristics of cancer is uncontrolled cell proliferation as well as loss of cells adhesion in the case of metastases. Cadherins and catenins are the molecules responsible for cell-to-cell interaction.
Alicja Maria Ozga, Aleksandra Obuchowska, Justyna Wójcik, Arkadiusz Standyło, Paulina Piotrowska   +4 more
doaj   +1 more source