Results 91 to 100 of about 10,852 (292)

Phosphorylation Reduces the Mechanical Stability of the α‐Catenin/ β‐Catenin Complex [PDF]

Angewandte Chemie International Edition, 2019
AbstractThe α‐catenin/β‐catenin complex serves as a critical molecular interface involved in cadherin–catenin‐based mechanosensing at the cell–cell adherence junction that plays a critical role in tissue integrity, repair, and embryonic development.
Shimin Le, Miao Yu, Jie Yan
openaire   +3 more sources

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Phosphorylation of β-Catenin by AKT Promotes β-Catenin Transcriptional Activity [PDF]

Journal of Biological Chemistry, 2007
Increased transcriptional activity of beta-catenin resulting from Wnt/Wingless-dependent or -independent signaling has been detected in many types of human cancer, but the underlying mechanism of Wnt-independent regulation is poorly understood. We have demonstrated that AKT, which is activated downstream from epidermal growth factor receptor signaling,
Dexing, Fang, David, Hawke, Yanhua, Zheng, Yan, Xia, Jill, Meisenhelder, Heinz, Nika, Gordon B, Mills, Ryuji, Kobayashi, Tony, Hunter, Zhimin, Lu   +9 more
openaire   +2 more sources

Force transmission in epithelial tissues [PDF]

, 2016
In epithelial tissues, cells constantly generate and transmit forces between each other. Forces generated by the actomyosin cytoskeleton regulate tissue shape and structure and also provide signals that influence cells' decisions to divide, die, or ...
Martin, Adam C., Vasquez, Claudia G.
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Altered expression of adhesion molecules and epithelial-mesenchymal transition in silica-induced rat lung carcinogenesis [PDF]

, 2004
Loss of the epithelial phenotype and disruption of adhesion molecules is a hallmark in the epithelial-mesenchymal transition (EMT) reported in several types of cancer.
Blanco, D. (D.), Elizegi, E. (E.), Esteller, M. (Manel), Fraga, M.F. (Mario F.), Lecanda, F. (Fernando), Montuenga-Badia, L.M. (Luis M.), Pino, I. (Irene), Saffiotti, U. (Umberto), Vicent, S. (Silvestre)   +8 more
core   +1 more source

Sea Urchin‐Inspired Immuno‐Instructive Ionic Flow Drives MSCs‐Macrophage Communication to Promote Bone Regeneration

Advanced Materials, EarlyView.
ABSTRACT Bone tissue regeneration is a complex physiological process dependent on the spatiotemporal coordination of immune cells and stem cells. Conventional research primarily elucidates the mechanism through which materials facilitate bone formation by initially modulating macrophages and subsequently encouraging the osteogenic differentiation of ...
Yang Lu, Kun Su, Daqian Liu, Chunyu Liu, Muyan Qin, Shuaijie Li, Pengfei Tian, Yansong Wang, Yingbo Wang, Lei Chu, Xu Cui, Haobo Pan   +11 more
wiley   +1 more source

Ctnna3 Deficiency Promotes Heart Regeneration by Enhancing Cardiomyocyte Proliferation in Neonatal Mice

Frontiers in Bioscience-Landmark
Background: Heart regeneration requires renewal of lost cardiomyocytes. However, the mammalian heart loses its proliferative capacity soon after birth, and the molecular signaling underlying the loss of cardiac proliferation ...
Sha Zou, Wuhou Dai, Wufan Tao, Jifen Li, Zeyi Cheng, Hongyan Wang   +5 more
doaj   +1 more source

SDF-1 alone and in co-operation with HGF regulates biology of human cervical carcinoma cells.

Folia Histochemica et Cytobiologica, 2006
Stromal Derived Factor-1 (SDF-1)-CXCR4 axis plays a pivotal role in biology and metastasis of several tumors. The aim of this study was to see if SDF-1 alone or in combination with Hepatocyte Growth Factor (HGF) affects biology of human cervical ...
Alfred B Jenson, Marcin Wysoczynski, Ewa Lesko, Justyna Drukala, Marcin Majka, Mariusz Z Ratajczak   +5 more
doaj   +1 more source

Heparanase Loosens E-Cadherin-Mediated Cell-Cell Contact via Activation of Src

Frontiers in Oncology, 2020
Activity of heparanase, responsible for cleavage of heparan sulfate (HS), is strongly implicated in tumor metastasis. This is due primarily to remodeling of the extracellular matrix (ECM) that becomes more prone to invasion by metastatic tumor cells.
Victoria Cohen-Kaplan, Neta Ilan, Israel Vlodavsky   +2 more
doaj   +1 more source