Results 71 to 80 of about 10,852 (292)

PRL-3 and E-cadherin show mutual interactions and participate in lymph node metastasis formation in gastric cancer [PDF]

, 2014
E-cadherin, a transmembrane adhesion molecule, and phosphatase of regenerating liver 3 (PRL-3) protein, a member of the family of tyrosine phosphatases, seem to be responsible for cancer cell migration.
Andrzej Kemona, Anna Pryczynicz, Dariusz Cepowicz, Katarzyna Guzińska-Ustymowicz, Katarzyna Niewiarowska   +4 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

E-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet [PDF]

, 2007
Background/Aims: The efficient secretion of insulin from beta-cells requires extensive intra-islet communication. The cell surface adhesion protein epithelial (E)-cadherin (ECAD) establishes and maintains epithelial tissues such as the islets of ...
Bamji SX, Braga VMM, Brereton HC, Cabrera O, Collares-Buzato CB, Dahl U, Gareth J. Rogers, Gey GO, Gray E, Hellman B, Hills CE, Hodgkin MN, Kanno Y, Matsuda T, Matthew N. Hodgkin, Musil LS, Paul E. Squires, Piccoli G, Shih DQ, Squires PE, Squires PE, Woodfield RJ   +21 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Plakoglobin Reduces the in vitro Growth, Migration and Invasion of Ovarian Cancer Cells Expressing N-Cadherin and Mutant p53. [PDF]

PLoS ONE, 2016
Aberrant expression of cadherins and catenins plays pivotal roles in ovarian cancer development and progression. Plakoglobin (PG, γ-catenin) is a paralog of β-catenin with dual adhesive and signaling functions.
Mahsa Alaee, Ghazal Danesh, Manijeh Pasdar   +2 more
doaj   +1 more source

Proteomic Analysis Unveils Expressional Changes in Cytoskeleton- and Synaptic Plasticity-Associated Proteins in Rat Brain Six Months after Withdrawal from Morphine

Life, 2021
Drug withdrawal is associated with abstinence symptoms including deficits in cognitive functions that may persist even after prolonged discontinuation of drug intake.
Zdenka Drastichova, Lucie Hejnova, Radka Moravcova, Jiri Novotny   +3 more
doaj   +1 more source

The  -Catenin Destruction Complex [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
The Wnt/β-catenin pathway is highly regulated to insure the correct temporal and spatial activation of its target genes. In the absence of a Wnt stimulus, the transcriptional coactivator β-catenin is degraded by a multiprotein "destruction complex" that includes the tumor suppressors Axin and adenomatous polyposis coli (APC), the Ser/Thr kinases GSK-3 ...
Jennifer L, Stamos, William I, Weis
openaire   +2 more sources

Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin [PDF]

, 2017
published_or_final_versio
Ai, N, Chan, SW, Chong, CM, Dang, Y, Hoi, MPM, Hou, T, Kwan, YW, Lee, SM, Leung, GPH, Li, S, Pan, P, Shen, M   +11 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Plakophilin-3 is required for late embryonic amphibian development, exhibiting roles in ectodermal and neural tissues. [PDF]

PLoS ONE, 2012
The p120-catenin family has undergone a significant expansion during the evolution of vertebrates, resulting in varied functions that have yet to be discerned or fully characterized. Likewise, members of the plakophilins, a related catenin subfamily, are
William A Munoz, Malgorzata Kloc, Kyucheol Cho, Moonsup Lee, Ilse Hofmann, Amy Sater, Kris Vleminckx, Pierre D McCrea   +7 more
doaj   +1 more source