Results 111 to 120 of about 6,280 (288)

Endothelial Pim3 kinase protects the vascular barrier during lung metastasis

Nature Communications
Endothelial cells (ECs) form a tissue-specific barrier for disseminating cancer cells in distant organs. However, the molecular regulation of the ECs in the metastatic niche remains unclear.
Niina M. Santio, Keerthana Ganesh, Pihla P. Kaipainen, Aleksi Halme, Fatemeh Seyednasrollah, Emad Arbash, Satu Hänninen, Riikka Kivelä, Olli Carpen, Pipsa Saharinen   +9 more
doaj   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

DMSO improves E-cadherin interaction with PIPKIγ, β- and p120-catenins.

, 2013
CHO cells transduced with the empty vector (Mock) or with WT, R749W or E757K hEcadherin were treated with 2% DMSO or with Medium, and the interaction of E-cadherin with PIPKIγ (A), p120- (B) and β-catenins (C) was assessed by PLA.
Ola Söderberg (238362), Joana Simões-Correia (176247), Raquel Seruca (87028), Joana Figueiredo (176254), Gianpaolo Suriano (87029)   +4 more
core   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Beta-catenin expression in psoriasis

Indian Dermatology Online Journal, 2015
Background: Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte proliferation and differentiation. Beta-catenin participates in intercellular adhesion.
Mohamed Abd El-wahed Gaber, Mona Abd El-Halim Kandil, Shawki Mahmoud El-Farargy, Doaa Abd Elmoniem Galbet   +3 more
doaj   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Actin Cytoskeleton Remodeling Accompanied by Redistribution of Adhesion Proteins Drives Migration of Cells in Different EMT States

Cells
Epithelial–mesenchymal transition (EMT) is a process during which epithelial cells lose epithelial characteristics and gain mesenchymal features. Here, we used several cell models to study migratory activity and redistribution of cell–cell adhesion ...
Alla S. Ilnitskaya, Nikita I. Litovka, Svetlana N. Rubtsova, Irina Y. Zhitnyak, Natalya A. Gloushankova   +4 more
doaj   +1 more source

β- catenin Expression and Its Relation to Bryne’s Invasive Grading System in Oral Squamous Cell Carcinoma

Journal of Baghdad College of Dentistry, 2016
Background: Invasion in oral cancer involves alterations in cell-cell and cell-matrix interactions that accompanied by loss of cell adhesion. Catenins stabilize cellular adherence junctions by binding to E-cadherin, which further mediates cell-cell ...
Marwa Abdulsalam Hamied, Balkees Taha Garib, Dena Nadhim Mohammad   +2 more
doaj   +1 more source

Fine structural immunocytochemistry of catenins in amphibian and mammalian muscle

, 1996
In adherens junctions, alpha- and beta-catenin serve to link cadherins to the cortical cytoskeleton. Immunofluorescence and immuno-electron microscopy have been applied to elucidate the nature and localization of cadherin/catenin-mediated cell-cell ...
Schwarz, H., Schneider, S., Kurth, T. ; https://orcid.org/, Hausen, P.   +3 more
core   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source