Results 111 to 120 of about 5,972 (292)

Role of Catenins in the Development of Gap Junctions in Rat Cardiomyocytes

, 2008
Gap junctions are intercellular communicating channels responsible for the synchronized activity of cardiomyocytes. Recent studies have shown that the membrane-associated guanylate kinase protein, zonula occludens-1 (ZO-1) can bind to catenins in ...
WU, JIAHN-CHUN;TSAI, RU-YIN;CHUNG, TUN- HUI, 吳建春;蔡如愔;鍾敦輝   +1 more
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Advanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong, Yi‐Juan Tan, Yan‐Xin Duan, Jing‐Yao Luo, Ming‐Jie Luo, Yi‐Wei Liu, Xin Wang, Yi Luo, Teng‐Fei Wan, Yong Zhou, Zheng‐Guang Wang, Guo‐Wen Hu, Hao Yin, Xin‐Yue Hu, Zhen‐Xing Wang, Ze‐Hui He, Si‐Yi Cheng, Wei Du, Zhe Guan, Hai‐Li Lang, Hong‐Ji Liu, Jia Cao, Peng Chen, Jiang‐Hua Liu, Hui Xie, Chun‐Yuan Chen   +28 more
wiley   +1 more source

Beta-catenin expression in psoriasis

Indian Dermatology Online Journal, 2015
Background: Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte proliferation and differentiation. Beta-catenin participates in intercellular adhesion.
Mohamed Abd El-wahed Gaber, Mona Abd El-Halim Kandil, Shawki Mahmoud El-Farargy, Doaa Abd Elmoniem Galbet   +3 more
doaj   +1 more source

New functions for alpha-catenins in health and disease: from cancer to heart regeneration.

, 2015
Strong cell-cell adhesion mediated by adherens junctions is dependent on anchoring the transmembrane cadherin molecule to the underlying actin cytoskeleton.
Li, Jifen, Vite, Alexia, Radice, Glenn L.   +2 more
core  

Spatiotemporal expression of catenins, ZO-1, and occludin during early polarization of hepatic WIF-B9 cells

, 2001
WIF-B9 is a suitable model for in vitro studies of hepatocyte polarity. To better understand polarity establishment, we have localized key proteins of the adhesion system, cytoskeleton, and tight junctions soon after plating, when most cells are isolated
D. Cassio, C. Decaens
core   +1 more source

Caveolin-1 opens endothelial cell junctions by targeting catenins [PDF]

, 2011
A fundamental phenomenon in inflammation is the loss of endothelial barrier function, in which the opening of endothelial cell junctions plays a central role.
Seebach, Jochen, Afanasieva, Tatiana, Engelhardt, B., Schnittler, H.J., Hans-Joachim Schnittler, Grossklaus, Sylvia, Minten, Carsten, Taha, Abdallah Abu, Liebner, S., Grossklaus, S., Arsenijevic, Y., Liebner, Stefan, Marek Drab, Drab, M., Kronstein, R., Minten, C., Sylvia Großklaus, Afanasieva, T., Arsenijevic, Yvan, Kronstein, Romy, Jochen Seebach, Taha, A.A., Schnittler, Hans-Joachim, Seebach, J., Romy Kronstein, Engelhardt, Britta, Britta Engelhardt, Drab, Marek, Stefan Liebner, Carsten Minten, Abdallah Abu Taha, Tatiana Afanasieva, Yvan Arsenijevic   +32 more
core   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Actin Cytoskeleton Remodeling Accompanied by Redistribution of Adhesion Proteins Drives Migration of Cells in Different EMT States

Cells
Epithelial–mesenchymal transition (EMT) is a process during which epithelial cells lose epithelial characteristics and gain mesenchymal features. Here, we used several cell models to study migratory activity and redistribution of cell–cell adhesion ...
Alla S. Ilnitskaya, Nikita I. Litovka, Svetlana N. Rubtsova, Irina Y. Zhitnyak, Natalya A. Gloushankova   +4 more
doaj   +1 more source

β- catenin Expression and Its Relation to Bryne’s Invasive Grading System in Oral Squamous Cell Carcinoma

Journal of Baghdad College of Dentistry, 2016
Background: Invasion in oral cancer involves alterations in cell-cell and cell-matrix interactions that accompanied by loss of cell adhesion. Catenins stabilize cellular adherence junctions by binding to E-cadherin, which further mediates cell-cell ...
Marwa Abdulsalam Hamied, Balkees Taha Garib, Dena Nadhim Mohammad   +2 more
doaj   +1 more source