Results 61 to 70 of about 10,779 (272)

α-Catenin overrides Src-dependent activation of β-catenin oncogenic signaling [PDF]

Molecular Cancer Therapeutics, 2008
Abstract Loss of α-catenin is one of the characteristics of prostate cancer. The catenins (α and β) associated with E-cadherin play a critical role in the regulation of cell-cell adhesion. Tyrosine phosphorylation of β-catenin dissociates it from E-cadherin and facilitates its entry into the nucleus, where β-catenin acts as a ...
Landon J, Inge, Sigrid A, Rajasekaran, Daniel, Wolle, Sonali P, Barwe, Sergey, Ryazantsev, Charles M, Ewing, William B, Isaacs, Ayyappan K, Rajasekaran   +7 more
openaire   +2 more sources

Peptide Bbeta(15-42) preserves endothelial barrier function in shock [PDF]

, 2009
Loss of vascular barrier function causes leak of fluid and proteins into tissues, extensive leak leads to shock and death. Barriers are largely formed by endothelial cell-cell contacts built up by VE-cadherin and are under the control of RhoGTPases. Here
Atrasheuskaya, Alena, Bukin, Eugenij, Friedl, Peter, Gröger, Marion, Hofer-Warbinek, Renate, Ignatyev, George, Knapp, Sylvia, Matt, Ulrich, Pasteiner, Waltraud, Petzelbauer, Peter, Reingruber, Sonja, Zacharowski, Kai, Zinkl, Daniela   +12 more
core  

Perspective of synaptic protection after post-infarction treatment with statins [PDF]

, 2015
Stroke is the second most common cause of death in people over 45 years of age in Colombia and is the leading cause of permanent disability worldwide. Cerebral ischemia is a stroke characterized by decreased blood flow due to the occlusion of one or more
Angel Cespedes-Rubio, Gloria Patricia Cardona-Gómez, Johanna Andrea Gutiérrez-Vargas   +2 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

The Importance of Multifrequency Impedance Sensing of Endothelial Barrier Formation Using ECIS Technology for the Generation of a Strong and Durable Paracellular Barrier

Biosensors, 2018
In this paper, we demonstrate the application of electrical cell-substrate impedance sensing (ECIS) technology for measuring differences in the formation of a strong and durable endothelial barrier model.
Laverne D. Robilliard, Dan T. Kho, Rebecca H. Johnson, Akshata Anchan, Simon J. O’Carroll, Euan Scott Graham   +5 more
doaj   +1 more source

Acetylation of β-Catenin by p300 Regulates β-Catenin-Tcf4 Interaction [PDF]

Molecular and Cellular Biology, 2004
Lysine acetylation modulates the activities of nonhistone regulatory proteins and plays a critical role in the regulation of cellular gene transcription. In this study, we showed that the transcriptional coactivator p300 acetylated beta-catenin at lysine 345, located in arm repeat 6, in vitro and in vivo.
Lévy, Laurence, Wei, Yu, Labalette, Charlotte, Wu, Yuanfei, Renard, Claire-Angélique, Buendia, Marie Annick, Neuveut, Christine   +6 more
openaire   +3 more sources

Altered expression of adhesion molecules and epithelial-mesenchymal transition in silica-induced rat lung carcinogenesis [PDF]

, 2004
Loss of the epithelial phenotype and disruption of adhesion molecules is a hallmark in the epithelial-mesenchymal transition (EMT) reported in several types of cancer.
Blanco, D. (D.), Elizegi, E. (E.), Esteller, M. (Manel), Fraga, M.F. (Mario F.), Lecanda, F. (Fernando), Montuenga-Badia, L.M. (Luis M.), Pino, I. (Irene), Saffiotti, U. (Umberto), Vicent, S. (Silvestre)   +8 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Immunohistochemical analysis of E-cadherin,  -catenin,  -catenin,  -catenin, and neural cell adhesion molecule (NCAM) in chordoma [PDF]

Journal of Clinical Pathology, 2001
Aims—the epithelioid features seen in chordoma are unique among mesenchymal tumours. However, no detailed analysis regarding cell–cell communication has been conducted in this epithelioid tumour. The aims of this study were to investigate cell–cell communication in chordoma.
T Naka, Y Oda, Y Iwamoto, N Shinohara, H Chuman, M Fukui, M Tsuneyoshi   +6 more
openaire   +1 more source

Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function [PDF]

, 2012
Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion.
Bennett, J., Hills, C. E., Liu, K.-K., Siamantouras, E., Squires, P. E., Younis, M. Y.G.   +5 more
core   +2 more sources