Results 31 to 40 of about 16,226 (208)

Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor. [PDF]

, 2016
Background and objectivesObesity is a global epidemic which increases the risk of the metabolic syndrome. Cathelicidin (LL-37 and mCRAMP) is an antimicrobial peptide with an unknown role in obesity.
Bakirtzi, K, Cheng, M, Fisseha, E, Fleshner, P, Gallo, RL, Hing, TC, Ho, S, Hoang-Ngoc Tran, D, Hoang-Yen Tran, D, Karagiannides, I, Koon, HW, Law, I, Lee, EC, Lee, JE, Li, Z, Mattai, SA, McGovern, DPB, Ortiz, C, Robbins, L, Sallam, T, Shieh, C, Shih, DQ, Sideri, A, Su, B, Targan, SR, Vu, M   +25 more
core   +1 more source

Snake Cathelicidin NA-CATH and Smaller Helical Antimicrobial Peptides Are Effective against Burkholderia thailandensis. [PDF]

PLoS Neglected Tropical Diseases, 2015
Burkholderia thailandensis is a Gram-negative soil bacterium used as a model organism for B. pseudomallei, the causative agent of melioidosis and an organism classified category B priority pathogen and a Tier 1 select agent for its potential use as a ...
Ryan J Blower, Stephanie M Barksdale, Monique L van Hoek   +2 more
doaj   +1 more source

Endopeptidase O promotes Streptococcus suis immune evasion by cleaving the host- defence peptide cathelicidins

Virulence, 2023
Streptococcus suis is a zoonotic Gram-positive bacterium that causes invasive infections such as sepsis and meningitis, threatening public health worldwide.
Mingjie Jin, Siyu Liang, Jing Wang, Huihui Zhang, Yueling Zhang, Wanjiang Zhang, Siguo Liu, Fang Xie   +7 more
doaj   +1 more source

Circulating cathelicidin levels correlate with mucosal disease activity in ulcerative colitis, risk of intestinal stricture in Crohn’s disease, and clinical prognosis in inflammatory bowel disease

BMC Gastroenterology, 2017
Background Cathelicidin (LL-37) is an antimicrobial peptide known to be associated with various autoimmune diseases. We attempt to determine if cathelicidin can accurately reflect IBD disease activity.
Diana Hoang-Ngoc Tran, Jiani Wang, Christina Ha, Wendy Ho, S. Anjani Mattai, Angelos Oikonomopoulos, Guy Weiss, Precious Lacey, Michelle Cheng, Christine Shieh, Caroline C. Mussatto, Samantha Ho, Daniel Hommes, Hon Wai Koon   +13 more
doaj   +1 more source

New aspects of the structure and mode of action of the human cathelicidin LL-37 revealed by the intrinsic probe p-cyanophenylalanine [PDF]

, 2015
The human cathelicidin peptide LL-37 is an important effector of our innate immune system and contributes to host defence with direct antimicrobial activity and immunomodulatory properties, and by stimulating wound healing.
Morgera, Francesca, Pacor, Sabrina, Rizzo, Roberto, Tossi, Alessandro, Xhindoli, Daniela, Zinth, Ursula   +5 more
core   +1 more source

Expression of human cathelicidin peptide LL-37 in inflammatory bowel disease [PDF]

Clinical and Experimental Immunology, 2017
Summary Cathelicidin peptide LL-37 plays an important role in the early host response against invading pathogens via its broad-spectrum anti-microbial activity. In this study, we investigated LL-37 expression in the inflamed mucosa of inflammatory bowel disease (IBD) patients.
S Kusaka, A Nishida, K Takahashi, S Bamba, H Yasui, M Kawahara, O Inatomi, M Sugimoto, A Andoh   +8 more
openaire   +2 more sources

Cathelicidins—Therapeutic antimicrobial and antitumor host defense peptides for oral diseases

Japanese Dental Science Review, 2011
The oral epithelium functions as a mechanical and protective barrier to resist bacterial infection. Several types of host defense peptides (HDPs), including defensins, cathelicidins, and histatins, may have important roles in innate host defense.
Kazuhiko Okumura
doaj   +1 more source

Antimicrobial peptides, disease severity and exacerbations in bronchiectasis [PDF]

, 2019
Rationale: Recently a frequent exacerbator phenotype has been described in bronchiectasis, but the underlying biological mechanisms are unknown. Antimicrobial peptides (AMPs) are important in host defence against microbes but can be proinflammatory in ...
Aliberti, Stefano, Blasi, Francesco, Cantó, Elisabet, Cassidy, Diane, Chalmers, James D., Keir, Holly R., Ong, Samantha, Oriano, Martina, Perea, Lídia, Rodrigo-troyano, Ana, Shoemark, Amelia, Sibila, Oriol, Smith, Alexandria Holly, Suarez-cuartin, Guillermo, Vidal, Silvia   +14 more
core   +2 more sources

Chronic Ethanol Exposure Effects on Vitamin D Levels among Subjects with Alcohol Use Disorder

Environmental Health Insights, 2016
Vitamin D has been previously recognized to play important roles in human immune system and function. In the pulmonary system, vitamin D regulates the function of antimicrobial peptides, especially cathelicidin/LL-37.
Olalekan Ogunsakin, Tete Hottor, Ashish Mehta, Maureen Lichtveld, Michael McCaskill   +4 more
doaj   +1 more source

Cathelicidin LL-37: An Antimicrobial Peptide with a Role in Inflammatory Skin Disease [PDF]

, 2012
Chronic inflammatory skin diseases such as atopic dermatitis, psoriasis or rosacea are very common. Although their exact pathogenesis is not completely understood all three diseases are characterized by dysregulation of cutaneous innate immunity ...
Reinholz, Markus, Ruzicka, Thomas, Schauber, Jürgen   +2 more
core   +2 more sources