Results 81 to 90 of about 16,226 (208)

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

Journal of Internal Medicine, Volume 299, Issue 3, Page 328-348, March 2026.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron, Jennifer S. Lin, Mark I. Ryder, Peter Bergman   +3 more
wiley   +1 more source

Short, Synthetic Cationic Peptides Have Antibacterial Activity against Mycobacterium smegmatis by Forming Pores in Membrane and Synergizing with Antibiotics

Antibiotics, 2015
Multicellular organisms are constantly exposed to a multitude of pathogenic microbes. Infection is inhibited in vivo by the innate and adaptive immune system. Mycobacterium species have emerged that are resistant to most antibiotics.
Kajal Gupta, Sameer Singh, Monique L. van Hoek   +2 more
doaj   +1 more source

Influence of Vitamin D Deficiency on the Level of Salivary cathelicidin LL-37 in relation to Dental Caries Experience: A Case-Control Study

مجله كليه طب الكندي, 2023
Background: Vitamin D improves innate immunity by enhancing the expression of antimicrobial peptides. The antimicrobial action of cathelicidin is widespread and effective against cariogenic bacteria.
Narjes M. Alhelfi, Nibal M. Hobi
doaj   +1 more source

Cathelicidin preserves intestinal barrier function in polymicrobial sepsis. [PDF]

, 2020
ObjectivesThe intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammation. Previous studies reported that
Chan, Hung, Chan, Matthew TV, Cho, Chi H, Gallo, Richard L, Gin, Tony, Ho, Idy HT, Ho, Jeffery, Hu, Wei, Leung, Czarina CH, Li, Qing, Liang, Yonghao, Ling, Lowell, Liu, Xiaodong, Tse, Gary, Ugwu, Felix N, Wong, Sunny H, Wong, Wai Tat, Wu, William KK, Yau, Johnny CW, Yu, Jun, Zeng, Judeng, Zhang, Lin, Zhang, Yuchen   +22 more
core   +1 more source

The effect of 14 weeks of vitamin D3 supplementation on antimicrobial peptides and proteins in athletes [PDF]

, 2016
Heavy training is associated with increased respiratory infection risk and antimicrobial proteins are important in defence against oral and respiratory tract infections.
Cheng-Shiun He, Ellie Tanqueray, He C. S., James Teah, Jay Rudland-Thomas, Jonathan Tang, Kirsty Brown, Michael Gleeson, Stephen Renwick, William D. Fraser   +9 more
core   +1 more source

Advances in the Role of Adipose Tissue in Promoting Injury Repair and Resist Infection

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background In recent years, adipose tissue (AT) transplantation has increasingly been noticed by many people in the field of tissue repair and regeneration. Accumulating evidence demonstrates that AT exerts dual functions in promoting tissue repair and conferring anti‐infective properties, with distinct biological effects attributed to its ...
Xi Duan, Run Li, Lei Fu, Jiali Yang, Zhean Zhan   +4 more
wiley   +1 more source

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
core   +1 more source

Peptide OH‐CATH30 Mitigates Cachexia‐Induced Muscle Atrophy via Modulation of TLR4‐Associated Inflammation

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Cachexia, characterized by severe weight loss and muscle atrophy, frequently occurs in chronic conditions such as sepsis, cancer and chemotherapy, with limited effective treatments. Despite similar clinical manifestations, the underlying mechanisms across different disease contexts remain unclear.
Qiquan Wang, Jian Li, Mengqi Yang, Caifen Guo, Ming Zhang, Chunping Huang, Xiang Wang, Dongqin Zhang, Lin Zeng, Hao Ke, Yunling Wen, Shengan Li, Wenhui Lee, Limin Zhao, Xinqiang Lan, Yang Xiang   +15 more
wiley   +1 more source

Studies on Staphylococcus epidermidis biofilm formation and the bacterial interaction with the human cathelicidin antimicrobial peptide LL-37 [PDF]

, 2014
The long-term use of central venous catheters for delivering nutrients and drugs in preterm neonates has been related to nosocomial infections. The majority of late-onset sepsis in very preterm infants (
Hell, Eva
core   +1 more source

Lignin Nanoparticles Containing Cobalt‐Cyanine Complexes: Potential Multifunctional Platforms for Photoacoustic Imaging and Photothermal Treatment of Bacterial Biofilms in Chronic Wounds

Macromolecular Bioscience, Volume 26, Issue 2, February 2026.
CoPc is combined with a lignin‐based material to obtain NPs sensitive to NIR irradiation and capable of ROS scavenging. Through the NPs, mild photothermal therapy can be achieved to act against bacterial biofilms. ABSTRACT Chronic wounds (CWs) are characterized by persistent inflammation and bacterial biofilms, which hinder healing and contribute to ...
Giulia Crivello, Matteo Felice Pezzuto, Paolo Armanetti, Claudio Cassino, Chiara Ceresa, Letizia Fracchia, Claudia Catarinicchia, Stefania Villani, Pietro Alifano, Christian Demitri, Luca Menichetti, Tzanko Tzanov, Gianluca Ciardelli, Clara Mattu   +13 more
wiley   +1 more source