Results 11 to 20 of about 191,378 (381)

MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L

bioRxiv, 2021
A number of inhibitors have been developed for the SARS-CoV-2 main protease (MPro) as potential COVID-19 medications but little is known about their selectivity.
Xinyu R Ma, Yugendar R. Alugubelli, Yuying Ma, E. Vatansever, D. A. Scott, Yuchen Qiao, Ge-Shu Yu, Shiqing Xu, W. Liu   +8 more
semanticscholar   +1 more source

Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L

Journal of Medicinal Chemistry, 2021
Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a promising drug target for novel antivirals against SARS-CoV-2.
Anneliese S. Ashhurst, A. H. Tang, Pavla Fajtová, Michael C Yoon, A. Aggarwal, Max J Bedding, Alexander Stoye, L. Beretta, D. Pwee, A. Drelich, Danielle Skinner, Linfeng Li, T. Meek, J. McKerrow, V. Hook, C. Tseng, M. Larance, S. Turville, W. Gerwick, A. O’Donoghue, R. Payne   +20 more
semanticscholar   +1 more source

Cathepsin D—Managing the Delicate Balance

Pharmaceutics, 2021
Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin D manages protein turnover degrading misfolded and aggregated proteins and favors apoptosis in the case of proteostasis disruption.
O. Mijanović, Anastasiia Petushkova, Ana Brankovic, B. Turk, A. Solovieva, Angelina Nikitkina, S. Bolevich, P. Timashev, A. Parodi, A. Zamyatnin   +9 more
semanticscholar   +1 more source

Cathepsin K: The Action in and Beyond Bone

Frontiers in Cell and Developmental Biology, 2020
Cathepsin K (CatK) is one of the most potent proteases in lysosomal cysteine proteases family, of which main function is to mediate bone resorption. Currently, CatK is among the most attractive targets for anti-osteoporosis drug development.
Rongchen Dai, Zeting Wu, H. Chu, Jun Lu, Aiping Lyu, Jin Liu, Ge Zhang   +6 more
semanticscholar   +1 more source

Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction

Frontiers in Cell and Developmental Biology, 2020
The mechanisms leading to NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome activation are still debated. It is well established that oligomerized NLRP3 interacts with apoptosis associated Speck-like protein containing a CARD ...
Angélique Chevriaux, T. Pilot, V. Derangère, Harmonie Simonin, P. Martine, Fanny Chalmin, F. Ghiringhelli, C. Rébé   +7 more
semanticscholar   +1 more source

Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth [PDF]

Journal of Cell Science, 2015
Marielle Boonen, Catherine Staudt, Florentine Gilis, Viola Oorschot, Judith Klumperman, Michel Jadot   +5 more
openalex   +2 more sources

A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L

Molecules, 2020
Human cathepsin L belongs to the cathepsin family of proteolytic enzymes with primarily an endopeptidase activity. Although its primary functions were originally thought to be only of a housekeeping enzyme that degraded intracellular and endocytosed ...
Dibyendu Dana, Sanjai K. Pathak
semanticscholar   +1 more source

THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN

The Journal of General Physiology, 1938
In the hemoglobin method for the estimation of proteinase, denatured hemoglobin is digested under standard conditions, the undigested hemoglobin is precipitated with trichloracetic acid, and the amount of unprecipitated protein split products, which is a
M. L. Anson
semanticscholar   +1 more source

IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells [PDF]

, 2012
The cysteine-type peptidase cathepsin X is highly upregulated in several cancers and presumably promotes tumor invasion through bypassing cellular senescence. Here, we present first evidence that the underlying mechanism may involve the regulation of the
Bunsen, Thea, Fruth, Maximilian, Kraus, Steffen, Nägler, Dorit K.   +3 more
core   +1 more source

Zymography of proteases in honey bees (Apis Mellifera) infected with Nosema ceranae [PDF]

Veterinarski Glasnik
Nosemosis is one of the most important honey bee diseases and is caused by two fungal species of the genus Nosema, i.e., Nosema apis and Nosema ceranae.
Doghuzlu Mohammad Afrasiabi, Nabian Sedigheh, Paghaleh Gholam Ali Nehzati, Taheri Mohammad, Asadollahi Zahra, Akhzari Soheila   +5 more
doaj   +1 more source