Results 241 to 250 of about 94,483 (310)

CCN1/Cyr61 associates with β-amyloid levels in human cerebrospinal fluids. [PDF]

iScience
Shinohara M, Momota H, Saito T, Takenobu C, Kasuga K, Gheni G, Kawai K, Morishima M, Saito Y, Shindo A, Yasuno F, Ikeuchi T, Fukumori A, Sato N.   +13 more
europepmc   +1 more source

ASPSCR1: TFE3 Fusion‐Positive Epithelioid Angiomyolipoma/PEComa Lacking Melanocytic Markers: A Case Report

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Epithelioid angiomyolipoma is a rare perivascular epithelioid cell tumor subtype with malignant potential. Its morphology mimics renal cell carcinoma, posing diagnostic challenges. Half of these cases harbor TSC1/TSC2 alterations, and a small subset features TFE3 rearrangements, mutually exclusive of TSC mutations.
Yuka Kondo, Yoji Nagashima, Kenji Zennami, Megumi Sato, Sayaka Sumiyoshi, Akihiko Sugimoto, Madoka Isomura, Kiyoshi Takahara, Sachiko Minamiguchi   +8 more
wiley   +1 more source

A two-sample Mendelian randomization study and mediation analysis exploring the link between cathepsins and epilepsy. [PDF]

Epilepsia Open
Sun H, Ma D, Zhang W, Hou S, Chen Z, Li X, Meng H, Zhang D.   +7 more
europepmc   +1 more source

Silencing the Signal: The Metastasis Suppressor NDRG1 Disrupts Small Extracellular Vesicle‐Mediated Crosstalk in Pancreatic Cancer

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
NDRG1 suppresses pancreatic cancer progression by disrupting small extracellular vesicle biogenesis, altering cargo composition, and inhibiting EV uptake by cancer cells—thereby impairing tumour–stroma communication and fibrotic activation. This study reveals NDRG1 as a novel regulator of extracellular vesicle dynamics and a promising therapeutic ...
Jiawei Chang, Shafi Alenizi, Heloisa Zaccaron Milioli, Winston Lay, Saranya Pounraj, Yujie Li, Mekonnen Sisay Shiferaw, Elham Hosseini‐Beheshti, Zaklina Kovacevic   +8 more
wiley   +1 more source

Probing the activity of cysteine cathepsins in inflammatory bowel diseases. [PDF]

Sci Rep
Anderson BM, Ziegler AR, Campden RI, Wu H, Xu B, McQuade RM, Carbone SE, Poole DP, Lomax AE, Reed DE, Vanner SJ, Yates RM, Bunnett NW, Edgington-Mitchell LE.   +13 more
europepmc   +1 more source

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment

MedComm, Volume 7, Issue 7, July 2026.
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li, Yating Sun, Shuibin Lin, Quan Yuan   +3 more
wiley   +1 more source

NF-κB signaling pathway mediates the anti-tumor effect of Ginsenoside Rg1 in glioblastoma. [PDF]

Biochem Biophys Rep
Li S, Chang J, Chi B, Liu Y, Xiang J.
europepmc   +1 more source

Osteoarthritis: Epidemiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 7, July 2026.
Osteoarthritis (OA) is a multifactorial degenerative joint disease and a leading cause of disability worldwide. This graphical abstract summarizes the epidemiology, diagnostic strategies, and therapeutic approaches of OA. OA development is driven by aging, metabolic dysregulation, and mechanical stress, leading to progressive joint degeneration ...
Qin Ru, Dongliang Yuan, Shide Jiang, Xiaoxuan Zhao, Xu Liu, Yusheng Li, Shuguang Liu, Yuxiang Wu   +7 more
wiley   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

Sensing the spectrum: diverse stimuli for the NLRP3 inflammasome. [PDF]

Commun Biol
Xiao N, Lu Z, Chen J.
europepmc   +1 more source