Results 241 to 250 of about 143,203 (306)

A Dynamic Change of Microglial States Occurs During the Transition From Photoreceptor Degeneration to Regeneration in Zebrafish pde6c Mutants

Glia, Volume 74, Issue 6, June 2026.
Zebrafish pde6c mutants undergo photoreceptor degeneration from 5 dpf, but rods regenerate from 4 wpf. scRNA‐seq of retinal microglia reveals dynamic change of states between 5 dpf and 4 wpf. Two states emerge specifically during regeneration. ABSTRACT Microglia, brain‐resident immune cells, maintain brain homeostasis.
Darshini Ravishankar, Yuki Takeuchi, Ichiro Masai   +2 more
wiley   +1 more source

RAGE Re‐Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Cancer cachexia (CC) is a highly debilitating syndrome characterized by loss of body and muscle weight affecting most advanced cancer patients. The receptor for advanced glycation end‐products (RAGE) is expressed by several cell types and sustains the inflammatory response in acute and chronic diseases. Total ablation of RAGE (Ager−/
Sara Chiappalupi, Giulia Gentili, Laura Salvadori, Martina Paiella, Marcello Manfredi, Vittoria Federica Borrini, Kaamashri Mangar, Ann Marie Schmidt, Maurizio Muscaritoli, Francesca Riuzzi, Guglielmo Sorci   +10 more
wiley   +1 more source

Huntington's disease-associated ankyrin repeat palmitoyl transferases are rate-limiting factors in lysosome formation and fusion. [PDF]

PLoS Genet
Szenci G, Boda A, Nagy A, Károlyi D, Rubics A, Szőke Z, Falcsik G, Kovács T, Lőrincz P, Juhász G, Takáts S.   +10 more
europepmc   +1 more source

Significant expression of prosaposin in the intermediate lobe of mouse pituitary gland. [PDF]

Cell Tissue Res
Fuyuki A, Higuchi M, Homma T, Kitamura K, Onouchi S, Saito S.   +5 more
europepmc   +1 more source

Production of human cathepsins using Expi293™ mammalian cell expression system for off-target activity of cysteine protease inhibitor screening. [PDF]

Protein Sci
Turner Z, Arutyunova E, Bui DT, Han L, Kandadai AS, Bai B, Young HS, Mahal LK, Klassen JS, Lemieux MJ.   +9 more
europepmc   +1 more source

New Non-Saccharide Heparin Mimetics as Inhibitors of Cathepsin G. [PDF]

Chem Biol Drug Des
Afosah DK, Mottamal M, Kar S, Smith ELS, Selico-Dunn AC, Ahmed SA, Al-Horani RA.   +6 more
europepmc   +1 more source

Interferon gamma stimulates coordinated changes in LRRK2, GCase, and cathepsin activities in idiopathic and genetic Parkinson's disease monocytes. [PDF]

NPJ Parkinsons Dis
Hughes LP, Wallings RL, Agin-Liebes J, Alcalay RN, Garrido A, Tansey MG, Dzamko N.   +6 more
europepmc   +1 more source

Generation of osteoclast-like cells from human peripheral blood mononuclear cells using NFATc1 modified RNA. [PDF]

PLoS One
Srihirun S, Phruksaniyom C, Sriwantana T, Parakaw T, Sibmooh N, Vivithanaporn P, Suknuntha K.   +6 more
europepmc   +1 more source

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Cathepsin B

The International Journal of Biochemistry & Cell Biology, 1997
Cathepsin B is a lysosomal cysteine protease of the papain family. It functions in intracellular protein catabolism and in certain situations may also be involved in other physiological processes, such as processing of antigens in the immune response, hormone activation and bone turnover.
J S, Mort, D J, Buttle
openaire   +2 more sources