Results 221 to 230 of about 94,483 (310)

TFE3-rearranged renal cell carcinoma - Morphology and differential diagnosis. [PDF]

Urol Case Rep
Murugesan I, Yadav M, Kumar U, Agarwal P, Data S.   +4 more
europepmc   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Repositioning of Ertiprotafib via supramolecular assembly enables biomarker-guided therapy for acute kidney injury. [PDF]

J Nanobiotechnology
Jang H, Shin D, Park B, Lee JH, Ryu Y, Lee J, Ko E, Ko YS, Lee HY, Choi YE, Oh SW, Jo SK, Lee S, Park J, Kim K, Kim SH, Kim MG, Yang Y, Shim MK.   +18 more
europepmc   +1 more source

Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont, Tanya Singh, Luana Campos Soares, Mootaz M. Salman   +3 more
wiley   +1 more source

PARK19 truncation mutant Dnajc6 causes lysosomal deficiency-induced upregulation of pathologic α-synuclein and neurodegeneration of substantia nigra dopaminergic cells in PARK19 knockin mice. [PDF]

NPJ Parkinsons Dis
Wang HL, Chen YL, Chiu TJ, Chiu CC, Weng YH, Liu SY, Li AH, Yeh TH.   +7 more
europepmc   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP1617, a Cathepsin-S Inhibitor, in Healthy Adult Subjects. [PDF]

Clin Transl Sci
Kojima T, Chen W, Smulders R, Stanhope S, Kowalski D, Heo N, Moy S, Goldston A, Han D, Zhu T.   +9 more
europepmc   +1 more source

Serine Protease Inhibitory Activity of Kampo Medicines: One of the Mechanisms Against Cold Syndrome

Traditional &Kampo Medicine, Volume 13, Issue 2, August 2026.
Serine protease inhibitory activity is involved in the mechanism of Kampo medicines used for treating common cold symptoms Ryokankyomishingeninto exhibited serine protease inhibitory activity in vitro and in vivo. Ryokankyomishingeninto showed anti‐SARS‐CoV‐2 activity in VeroE6/TMPRSS2 cells. ABSTRACT Aim Serine proteases play a key role in coronavirus
Yukiko Matsuo, Reina Akaiwa, Miku Yanagioka, Mishizu Kikuchi, Yuuna Kawahara, Takuma Yoshida, Hidemasa Nakaminami, Niro Inaba, Yoshihiro Mimaki   +8 more
wiley   +1 more source

Cathepsin G is associated with cerebral vascular injury in myeloid leukemia: a pathologic insight into intracranial hemorrhage. [PDF]

Res Pract Thromb Haemost
Gi T, Kai K, Shide K, Nakamura E, Oguri N, Aman M, Maekawa K, Moriguchi-Goto S, Nakai M, Shimoda K, Hisada Y, Yamashita A.   +11 more
europepmc   +1 more source

Unravelling the Significance of Cystatin C and Bunina Bodies in Amyotrophic Lateral Sclerosis Pathogenesis

Neuropathology and Applied Neurobiology, Volume 52, Issue 4, August 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a fatal neurodegenerative disease primarily affecting motor neurons. Two key protein inclusions found in lower motor neurons serve as neuropathological hallmarks of the disease in human tissue: the TDP43‐positive inclusion and the cystatin C‐positive Bunina body.
Sarah M. Granger, Rosemary A. Staniforth, Asbjorg Osk Snorradottir, Johnathan Cooper‐Knock, Kurt J. De Vos, J. Robin Highley   +5 more
wiley   +1 more source