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Plant cathepsin B, a versatile protease [PDF]

Frontiers in Plant Science
Plant proteases are essential enzymes that play key roles during crucial phases of plant life. Some proteases are mainly involved in general protein turnover and recycle amino acids for protein synthesis.
Marianna Coppola, Lukas Mach, Patrick Gallois   +2 more
doaj   +6 more sources

Exploring the Association between Cathepsin B and Parkinson’s Disease [PDF]

Brain Sciences
Objective: The aim of this study is to investigate the association between Cathepsin B and Parkinson’s Disease (PD), with a particular focus on determining the role of N-acetylaspartate as a potential mediator.
Changhao Lu, Xinyi Cai, Shilin Zhi, Xiaofen Wen, Jiaxin Shen, Tommaso Ercoli, Elena Rita Simula, Carla Masala, Leonardo A. Sechi, Paolo Solla   +9 more
doaj   +4 more sources

Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells [PDF]

Cell Reports, 2017
Summary: Triple-negative breast cancer (TNBC) is considered incurable with currently available treatments, highlighting the need for therapeutic targets and predictive biomarkers.
Kyung-Min Yang, Eunjin Bae, Sung Gwe Ahn, Kyoungwha Pang, Yuna Park, Jinah Park, Jihee Lee, Akira Ooshima, Bora Park, Junil Kim, Yunshin Jung, Satoru Takahashi, Joon Jeong, Seok Hee Park, Seong-Jin Kim   +14 more
doaj   +2 more sources

Cathepsin B in human peripheral blood lymphocytes as a peripheral biomarker for cardiac hypertrophy [PDF]

Scientific Reports
Previous studies have demonstrated that cathepsin B is up-regulated in the myocardium of both mice and humans with pathological cardiac hypertrophy. However, it remains unknown whether cathepsin B is detectable in human peripheral blood lymphocytes (PBLs)
Dandan Feng, Chao Li, Wenjuan Gao, Yuying Sui, Shuxin Zhao, Yixing Wang, Guoying Zhang, Yan Dong, Jianchun Wang   +8 more
doaj   +2 more sources

Proteomic Analysis Of Silenced Cathepsin B Expression Suggests Non-Proteolytic Cathepsin B Functionality.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016
Cathepsin B (CTSB) is a lysosomal endo- and exopeptidase that is also secreted in high amounts by malignant and non-malignant cells. We determined the effect of CTSB on the tumor cell secretome by shRNA-mediated silencing of CTSB mRNA expression and subsequent proteomic LC-MS/MS analysis of the cell supernatants.
Florian Christoph Sigloch, Oliver Schilling   +1 more
openalex   +5 more sources

CD4-independent human immunodeficiency virus infection involves participation of endocytosis and cathepsin B. [PDF]

PLoS ONE, 2011
During a comparison of the infectivity of mNDK, a CD4-independent human immunodeficiency virus type 1 (HIV-1) strain, to various cell lines, we found that HeLa cells were much less susceptible than 293T and TE671 cells.
Hiroaki Yoshii, Haruka Kamiyama, Kensuke Goto, Kazunori Oishi, Nobuhiko Katunuma, Yuetsu Tanaka, Hideki Hayashi, Toshifumi Matsuyama, Hironori Sato, Naoki Yamamoto, Yoshinao Kubo   +10 more
doaj   +3 more sources

Cathepsin B Levels Correlate with the Severity of Canine Myositis [PDF]

Biomolecules
Cathepsins are protease enzymes vital for normal physiological functions, such as digestion, coagulation, hormone secretion, bone resorption, apoptosis, autophagy, and both innate and adaptive immunity.
Valeria De Pasquale, Emanuela Vaccaro, Federica Rossin, Mariangela Ciampa, Melania Scarcella, Orlando Paciello, Simona Tafuri   +6 more
doaj   +2 more sources

MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice.

PLoS ONE, 2010
BackgroundInvolvement of MMP-9, uPAR and cathepsin B in adhesion, migration, invasion, proliferation, metastasis and tumor growth has been well established.
Krishna Kumar Veeravalli, Chandramu Chetty, Shivani Ponnala, Christopher S Gondi, Sajani S Lakka, Daniel Fassett, Jeffrey D Klopfenstein, Dzung H Dinh, Meena Gujrati, Jasti S Rao   +9 more
doaj   +3 more sources

Cathepsin B as a potential serum biomarker for early diagnosis and progression of diabetic foot ulcer complicated with peripheral vascular disease. [PDF]

Sci Rep
Jin Y, Yao Y, Lin Y, Zhong J, Kong X, Liu Y, Li Y, Qiao J, Zhai A, Bi C.   +9 more
europepmc   +3 more sources

A Cathepsin B-Triggered CO-Releasing Molecule with a Non-Toxic Metal Core for Targeted Tumor Delivery. [PDF]

Angew Chem Int Ed Engl
Černauskienė I, Izquierdo-García E, Keller S, Betts H, Cariou K, Marchán V, Gasser G, Bernardes GJL.   +7 more
europepmc   +3 more sources