Results 1 to 10 of about 70,432 (242)

Cathepsin B in human peripheral blood lymphocytes as a peripheral biomarker for cardiac hypertrophy [PDF]

Scientific Reports
Previous studies have demonstrated that cathepsin B is up-regulated in the myocardium of both mice and humans with pathological cardiac hypertrophy. However, it remains unknown whether cathepsin B is detectable in human peripheral blood lymphocytes (PBLs)
Dandan Feng, Chao Li, Wenjuan Gao, Yuying Sui, Shuxin Zhao, Yixing Wang, Guoying Zhang, Yan Dong, Jianchun Wang   +8 more
doaj   +2 more sources

Cathepsin B Levels Correlate with the Severity of Canine Myositis [PDF]

Biomolecules
Cathepsins are protease enzymes vital for normal physiological functions, such as digestion, coagulation, hormone secretion, bone resorption, apoptosis, autophagy, and both innate and adaptive immunity.
Valeria De Pasquale, Emanuela Vaccaro, Federica Rossin, Mariangela Ciampa, Melania Scarcella, Orlando Paciello, Simona Tafuri   +6 more
doaj   +2 more sources

Exploring the Association between Cathepsin B and Parkinson’s Disease [PDF]

Brain Sciences
Objective: The aim of this study is to investigate the association between Cathepsin B and Parkinson’s Disease (PD), with a particular focus on determining the role of N-acetylaspartate as a potential mediator.
Changhao Lu, Xinyi Cai, Shilin Zhi, Xiaofen Wen, Jiaxin Shen, Tommaso Ercoli, Elena Rita Simula, Carla Masala, Leonardo A. Sechi, Paolo Solla   +9 more
doaj   +2 more sources

Plant cathepsin B, a versatile protease. [PDF]

Front Plant Sci
Plant proteases are essential enzymes that play key roles during crucial phases of plant life. Some proteases are mainly involved in general protein turnover and recycle amino acids for protein synthesis. Other proteases are involved in cell signalling, cleave specific substrates and are key players during important genetically controlled molecular ...
Coppola M, Mach L, Gallois P.
europepmc   +4 more sources

The Homology Modeling and Docking Investigation of Human Cathepsin B [PDF]

International Journal of Medical Toxicology and Forensic Medicine, 2020
Background: Cathepsin B comprises a group of lysosomal cysteine proteases belonging to the Papain family; it has an intracellular function in the process of protein catabolism, antigen processing in the immune response, and Alzheimer’s disease.
Afshin Khara, Ehsan Jahangirian, Hossein Tarrahimofrad   +2 more
doaj   +1 more source

Trafficking of Full-Length and N-Terminally Truncated Cathepsin B in Human Colorectal Carcinoma Cells

Applied Sciences, 2021
Cathepsin B is an endo-lysosomal cysteine protease. However, its increased expression and altered localization to the extracellular space, to mitochondria, or to the nucleus has been linked to tumor progression.
Tripti Tamhane, Robin W. Njenga, Roberta E. Burden, Heiko Büth, Gunhild M. Maelandsmo, Mads H. Haugen, Christopher J. Scott, Klaudia Brix   +7 more
doaj   +1 more source

Enhancement of Inhibitory Activity by Combining Allosteric Inhibitors Putatively Binding to Different Allosteric Sites on Cathepsin K

Molecules, 2023
Background: Cathepsin K, which is involved in bone resorption, is a good target for treating osteoporosis, but no clinically approved medicine has been developed.
Shun Sato, Kana Yamamoto, Moeno Ito, Katsutoshi Nishino, Takanao Otsuka, Kazuhiro Irie, Masaya Nagao   +6 more
doaj   +1 more source

Characterization of Cysteine Cathepsin Expression in the Central Nervous System of Aged Wild-Type and Cathepsin-Deficient Mice

Applied Sciences, 2022
The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk−/−) mice have learning and memory impairments.
Denise M. T. Yu, Stephanie Dauth, Michael B. Margineanu, Valentina Snetkova, Maren Rehders, Silvia Jordans, Klaudia Brix   +6 more
doaj   +1 more source

Human tumour cathepsin B. Comparison with normal liver cathepsin B [PDF]

Biochemical Journal, 1992
Cathepsin B was purified from normal human liver and several human tumour tissues and partially characterized. Three forms of cathepsin B, with molecular masses of 25 kDa, 26 kDa (the two appearing as a doublet) and 30 kDa, were detected in SDS/polyacrylamide gels.
Moin, K., Day, N., Sameni, M., Hasnain, Sadiq, Hirama, Tomoko, Sloane, B.   +5 more
openaire   +3 more sources

Development of a Peptide-Based Nano-Sized Cathepsin B Inhibitor for Anticancer Therapy

Pharmaceutics, 2023
Numerous cathepsin B inhibitors have been developed and are under investigation as potential cancer treatments. They have been evaluated for their ability to inhibit cathepsin B activity and reduce tumor growth.
So-Hyeon Park, Jun-Hyuck Lee, Seong-Bin Yang, Dong-Nyeong Lee, Tae-Bong Kang, Jooho Park   +5 more
doaj   +1 more source