Results 1 to 10 of about 346,021 (218)
Plant cathepsin B, a versatile protease [PDF]
Frontiers in Plant SciencePlant proteases are essential enzymes that play key roles during crucial phases of plant life. Some proteases are mainly involved in general protein turnover and recycle amino acids for protein synthesis.
Marianna Coppola +2 more
doaj +4 more sources
Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy 21 human cellular and mouse models. [PDF]
PLoS ONEDown syndrome, resulting from trisomy of human chromosome 21, is a common form of chromosomal disorder that results in intellectual disability and altered risk of several medical conditions. Individuals with Down syndrome have a greatly increased risk of
Yixing Wu +2 more
doaj +3 more sources
The Presence of Cathepsin B in Cartilage [PDF]
Biochemical Journal, 1967 S.Y. Ali
openaire +4 more sources
Exploring the Association between Cathepsin B and Parkinson’s Disease [PDF]
Brain SciencesObjective: The aim of this study is to investigate the association between Cathepsin B and Parkinson’s Disease (PD), with a particular focus on determining the role of N-acetylaspartate as a potential mediator.
Changhao Lu +9 more
doaj +2 more sources
The Homology Modeling and Docking Investigation of Human Cathepsin B [PDF]
International Journal of Medical Toxicology and Forensic Medicine, 2020 Background: Cathepsin B comprises a group of lysosomal cysteine proteases belonging to the Papain family; it has an intracellular function in the process of protein catabolism, antigen processing in the immune response, and Alzheimer’s disease.
Afshin Khara +2 more
doaj +1 more source
Applied Sciences, 2021 Cathepsin B is an endo-lysosomal cysteine protease. However, its increased expression and altered localization to the extracellular space, to mitochondria, or to the nucleus has been linked to tumor progression.
Tripti Tamhane +7 more
doaj +1 more source
Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis. [PDF]
PLoS ONE, 2012 Chronic HIV infection leads to the development of cognitive impairments, designated as HIV-associated neurocognitive disorders (HAND). The secretion of soluble neurotoxic factors by HIV-infected macrophages plays a central role in the neuronal ...
Eillen J Rodriguez-Franco +8 more
doaj +1 more source
Molecules, 2023 Background: Cathepsin K, which is involved in bone resorption, is a good target for treating osteoporosis, but no clinically approved medicine has been developed.
Shun Sato +6 more
doaj +1 more source
Development of a Peptide-Based Nano-Sized Cathepsin B Inhibitor for Anticancer Therapy
Pharmaceutics, 2023 Numerous cathepsin B inhibitors have been developed and are under investigation as potential cancer treatments. They have been evaluated for their ability to inhibit cathepsin B activity and reduce tumor growth.
So-Hyeon Park +5 more
doaj +1 more source
Human tumour cathepsin B. Comparison with normal liver cathepsin B [PDF]
Biochemical Journal, 1992 Cathepsin B was purified from normal human liver and several human tumour tissues and partially characterized. Three forms of cathepsin B, with molecular masses of 25 kDa, 26 kDa (the two appearing as a doublet) and 30 kDa, were detected in SDS/polyacrylamide gels.
Moin, K. +5 more
openaire +4 more sources