Results 11 to 20 of about 13,268,265 (360)
Cathepsin B is an executioner of ferroptosis
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2021 Ferroptosis is a necrotic form of cell death caused by inactivation of the glutathione system and uncontrolled iron-mediated lipid peroxidation. Increasing evidence implicates ferroptosis in a wide range of diseases from neurotrauma to cancer, highlighting the importance of identifying an executioner system that can be exploited for clinical ...
Pandian Nagakannan +3 more
openaire +3 more sources
Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction
Frontiers in Cell and Developmental Biology, 2020 The mechanisms leading to NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome activation are still debated. It is well established that oligomerized NLRP3 interacts with apoptosis associated Speck-like protein containing a CARD ...
Angélique Chevriaux +17 more
doaj +2 more sources
Cathepsin B as a cancer target [PDF]
Expert Opinion on Therapeutic Targets, 2013 Cathepsin B is of significant importance to cancer therapy as it is involved in various pathologies and oncogenic processes in humans. Numerous studies have shown that abnormal regulation of cathepsin B overexpression is correlated with invasive and metastatic phenotypes in cancers.
Jasti S. Rao, Christopher S. Gondi
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Cathepsin B: Multiple roles in cancer [PDF]
PROTEOMICS – Clinical Applications, 2014 Proteases, including intracellular proteases, play roles at many different stages of malignant progression. Our focus here is cathepsin B, a lysosomal cysteine cathepsin. High levels of cathepsin B are found in a wide variety of human cancers, levels that often induce secretion and association of cathepsin B with the tumor cell membrane.
Bonnie F. Sloane, Neha Aggarwal
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ACS Chemical Biology, 2021 Cathepsin B is a cysteine protease that normally functions within acidic lysosomes for protein degradation, but in numerous human diseases, cathepsin B translocates to the cytosol having neutral pH where the enzyme activates inflammation and cell death ...
Michael C Yoon +12 more
semanticscholar +1 more source
Applied Sciences, 2022 The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk−/−) mice have learning and memory impairments.
Denise M. T. Yu +6 more
doaj +1 more source
Pharmaceuticals, 2022 Cathepsin B is a lysosomal cysteine protease that plays an important role in cancer, atherosclerosis, and other inflammatory diseases. The suppression of cathepsin B can inhibit tumor growth.
Manish Jain +7 more
doaj +1 more source
CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma
Journal of experimental & clinical cancer research : CR, 2020 Mounting evidence suggests that solid tumors display the features of collective invasion, however, the molecular mechanisms are far from clear.
Shi-Jie Wang +9 more
semanticscholar +1 more source
In silico identification of potential natural product inhibitors of human proteases key to SARS-CoV-2 infection [PDF]
Molecules 2020, 25(17), 3822, 2020 Presently, there are no approved drugs or vaccines to treat COVID-19 which has spread to over 200 countries and is responsible for over 3,65,000 deaths worldwide. Recent studies have shown that two human proteases, TMPRSS2 and cathepsin L, play a key role in host cell entry of SARS-CoV-2.
arxiv +1 more source
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on CTSB (cathepsin B), with data on DNA, on the protein encoded, and where the gene is implicated.
Jevnikar, Z, Kos, J
openaire +3 more sources