Results 11 to 20 of about 12,525,351 (366)

Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction

Frontiers in Cell and Developmental Biology, 2020
The mechanisms leading to NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome activation are still debated. It is well established that oligomerized NLRP3 interacts with apoptosis associated Speck-like protein containing a CARD ...
Angélique Chevriaux, Angélique Chevriaux, Thomas Pilot, Thomas Pilot, Valentin Derangère, Valentin Derangère, Valentin Derangère, Harmonie Simonin, Harmonie Simonin, Pierre Martine, Pierre Martine, Fanny Chalmin, François Ghiringhelli, François Ghiringhelli, François Ghiringhelli, Cédric Rébé, Cédric Rébé, Cédric Rébé   +17 more
doaj   +2 more sources

Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection [PDF]

Journal of Experimental Medicine, 2016
Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic, and degenerative diseases in humans.
Gurung, Prajwal, Guy, Clifford S, Kanneganti, Thirumala-Devi, Karki, Rajendra, Lamkanfi, Mohamed, Lupfer, Christopher, Malireddi, RK Subbarao, Man, Si Ming, Neale, Geoffrey, Qi, Xiaopeng   +9 more
core   +2 more sources

Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin [PDF]

Theranostics, 2017
Cysteine cathepsins often contribute to cancer progression due to their overexpression in the tumour microenvironment and therefore present attractive targets for non-invasive diagnostic imaging. However, the development of highly selective and versatile
Grütter, Markus G, Kramer, Lovro, Renko, Miha, Seeger, Markus A, Turk, Boris, Turk, Dušan, Turk, Vito, Vasiljeva, Olga, Završnik, Janja   +8 more
core   +3 more sources

Cathepsin B: Multiple roles in cancer [PDF]

PROTEOMICS – Clinical Applications, 2014
Proteases, including intracellular proteases, play roles at many different stages of malignant progression. Our focus here is cathepsin B, a lysosomal cysteine cathepsin. High levels of cathepsin B are found in a wide variety of human cancers, levels that often induce secretion and association of cathepsin B with the tumor cell membrane.
Neha, Aggarwal, Bonnie F, Sloane
openaire   +3 more sources

Retraction: MMP-9, uPAR and Cathepsin B Silencing Downregulate Integrins in Human Glioma Xenograft Cells In Vitro and In Vivo in Nude Mice. [PDF]

PLoS One
PLOS One Editors.
europepmc   +3 more sources

The Homology Modeling and Docking Investigation of Human Cathepsin B [PDF]

International Journal of Medical Toxicology and Forensic Medicine, 2020
Background: Cathepsin B comprises a group of lysosomal cysteine proteases belonging to the Papain family; it has an intracellular function in the process of protein catabolism, antigen processing in the immune response, and Alzheimer’s disease.
Afshin Khara, Ehsan Jahangirian, Hossein Tarrahimofrad   +2 more
doaj   +1 more source

Cathepsin B [PDF]

Definitions, 2020
Cathepsin B (339 aa, ~38 kDa) is encoded by the human CTSB gene. This protein plays a role in proteolysis, immunity and the regulation of apoptosis.
openaire   +2 more sources

Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways

Cell Death and Disease, 2023
Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal and lysosomal compartments. It is involved in the turnover of intracellular and extracellular proteins.
Zhen Xie, Mengyuan Zhao, Chengxiang Yan, W. Kong, Fei Lan, Narengaowa, Shuxuan Zhao, Qinghu Yang, Zhantao Bai, H. Qing, Junjun Ni   +10 more
semanticscholar   +1 more source

Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions.

ACS Chemical Biology, 2021
Cathepsin B is a cysteine protease that normally functions within acidic lysosomes for protein degradation, but in numerous human diseases, cathepsin B translocates to the cytosol having neutral pH where the enzyme activates inflammation and cell death ...
Michael C Yoon, A. Solania, Zhenze Jiang, Mitchell P. Christy, Sonia Podvin, Charles Mosier, Christopher B. Lietz, Gen Ito, W. Gerwick, D. Wolan, Gregory R Hook, A. O’Donoghue, V. Hook   +12 more
semanticscholar   +1 more source

Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B.

Biochemistry, 2022
CA-074 is a selective inhibitor of cathepsin B, a lysosomal cysteine protease. CA-074 has been utilized in numerous studies to demonstrate the role of this protease in cellular and physiological functions. Cathepsin B in numerous human disease mechanisms
Michael C Yoon, Mitchell P. Christy, Von V Phan, W. Gerwick, Gregory R Hook, A. O’Donoghue, V. Hook   +6 more
semanticscholar   +1 more source