Results 21 to 30 of about 13,268,265 (360)
Aggregate, Volume 3, Issue 6, December 2022., 2022 The aggregation‐induced emission luminogens (AIEgens) propel the development of drug and gene delivery systems. The lit‐up AIEgens first serve for real‐time monitoring of the delivery processes and evaluation of therapeutic responses of drug/gene. The delicate design of AIEgens to form high‐level structural carrier remarkably enhances the delivery ...
Jie Sun, Xuewen He
wiley +1 more source
BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Drug repurposing has the potential to accelerate the discovery of TMPRSS2 inhibitors acting as COVID‐19 antivirals. In this regard, a low throughput screening led to the identification of BC‐11 as a covalent TMPRSS2 fragment inhibitor (IC50 = 1.44 µM), displaying significant SARS‐CoV‐2 entry inhibition (EC50 = 66 µM). Abstract Host cell entry of severe
Aurélien F. A. Moumbock +3 more
wiley +1 more source
Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging
Neural Regeneration Research, 2019 Interleukin-1β is a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer’s disease, Parkinson’s disease, stroke and persistent pain.
H. Nakanishi
semanticscholar +1 more source
Frontiers in Surgery, 2018 AimWe have previously identified and characterized cancer stem cell (CSC) subpopulations in liver metastasis from colon adenocarcinoma (LMCA). In this study we investigated the expression and localization of cathepsins B, D and G, in relation to these ...
Shreeja Mehrotra +9 more
doaj +1 more source
Attacking COVID-19 Progression using Multi-Drug Therapy for Synergetic Target Engagement [PDF]
Biomolecules 2021, 11(6), 787, 2020 COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population. Over the past 6 months, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, has already infected over 11.6 million (25% located in United States) and killed ...
arxiv +1 more source
Biomedicines, 2023 Cathpesin B is a multi-functional protease that plays numerous roles in physiology and pathophysiology. We hypothesized that actin cytoskeleton proteins that are substrates of cathepsin B, various lipids, and kinases that are regulated by lipids would be
Tamim Kawakibi +5 more
doaj +1 more source
Gastroenterology, 2017 BACKGROUND & AIMS: Acute pancreatitis is characterized by premature intracellular activation of digestive proteases within pancreatic acini and a consecutive systemic inflammatory response.
M. Sendler +12 more
semanticscholar +1 more source
Bone Microenvironment Modulates Expression and Activity of Cathepsin B in Prostate Cancer
Neoplasia: An International Journal for Oncology Research, 2005 Prostate cancers metastasize to bone leading to osteolysis. Here we assessed proteolysis of DOcollagen I (a bone matrix protein) and, for comparison, DO-collagen IV, by living human prostate carcinoma cells in vitro.
Izabela Podgorski +6 more
doaj +1 more source
The Role of Cathepsin B in Peritoneal Fibrosis due to Peritoneal Dialysis
International Journal of Nephrology, 2019 Glucose-containing peritoneal dialysis (PD) solution causes peritoneal fibrosis (PF) characterized by accumulation of extracellular matrix (ECM) in the submesothelial layer.
Su Ah Sung +4 more
doaj +1 more source
Cathepsin B cleavage of the trypsinogen activation peptide
BMC Gastroenterology, 2002 Background Cathepsin B is thought to play a central role in intrapancreatic trypsinogen activation and the onset of pancreatitis. A recent investigation of the cathepsin B mediated activability of wildtype trypsinogen and their mutations N29I, N29T and ...
Keim Volker, Bödeker Hans, Teich Niels
doaj +1 more source