Results 21 to 30 of about 12,525,351 (366)

Trafficking of Full-Length and N-Terminally Truncated Cathepsin B in Human Colorectal Carcinoma Cells

Applied Sciences, 2021
Cathepsin B is an endo-lysosomal cysteine protease. However, its increased expression and altered localization to the extracellular space, to mitochondria, or to the nucleus has been linked to tumor progression.
Tripti Tamhane, Robin W. Njenga, Roberta E. Burden, Heiko Büth, Gunhild M. Maelandsmo, Mads H. Haugen, Christopher J. Scott, Klaudia Brix   +7 more
doaj   +1 more source

Enhancement of Inhibitory Activity by Combining Allosteric Inhibitors Putatively Binding to Different Allosteric Sites on Cathepsin K

Molecules, 2023
Background: Cathepsin K, which is involved in bone resorption, is a good target for treating osteoporosis, but no clinically approved medicine has been developed.
Shun Sato, Kana Yamamoto, Moeno Ito, Katsutoshi Nishino, Takanao Otsuka, Kazuhiro Irie, Masaya Nagao   +6 more
doaj   +1 more source

Human tumour cathepsin B. Comparison with normal liver cathepsin B [PDF]

Biochemical Journal, 1992
Cathepsin B was purified from normal human liver and several human tumour tissues and partially characterized. Three forms of cathepsin B, with molecular masses of 25 kDa, 26 kDa (the two appearing as a doublet) and 30 kDa, were detected in SDS/polyacrylamide gels.
Moin, K., Day, N., Sameni, M., Hasnain, Sadiq, Hirama, Tomoko, Sloane, B.   +5 more
openaire   +3 more sources

Characterization of Cysteine Cathepsin Expression in the Central Nervous System of Aged Wild-Type and Cathepsin-Deficient Mice

Applied Sciences, 2022
The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk−/−) mice have learning and memory impairments.
Denise M. T. Yu, Stephanie Dauth, Michael B. Margineanu, Valentina Snetkova, Maren Rehders, Silvia Jordans, Klaudia Brix   +6 more
doaj   +1 more source

Development of a Peptide-Based Nano-Sized Cathepsin B Inhibitor for Anticancer Therapy

Pharmaceutics, 2023
Numerous cathepsin B inhibitors have been developed and are under investigation as potential cancer treatments. They have been evaluated for their ability to inhibit cathepsin B activity and reduce tumor growth.
So-Hyeon Park, Jun-Hyuck Lee, Seong-Bin Yang, Dong-Nyeong Lee, Tae-Bong Kang, Jooho Park   +5 more
doaj   +1 more source

CATHEPSIN B PLAY A CRITICAL ROLE IN AMYLOID β INFLUX VIA CEREBRAL ENDOTHELIAL CELLS DURING PORPHYROMONAS GINGIVALIS INFECTION [PDF]

Int J Neuropsychopharmacol
Shuge Gui, Zeng Fan, Yicong Liu, Junjun Ni, Zhou Wu   +4 more
europepmc   +3 more sources

Cathepsin B-Cleavable Polymeric Photosensitizer Prodrug for Selective Photodynamic Therapy: In Vitro Studies

Pharmaceuticals, 2022
Cathepsin B is a lysosomal cysteine protease that plays an important role in cancer, atherosclerosis, and other inflammatory diseases. The suppression of cathepsin B can inhibit tumor growth.
Manish Jain, Jordan Bouilloux, Ines Borrego, Stéphane Cook, Hubert van den Bergh, Norbert Lange, Georges Wagnieres, Marie-Noelle Giraud   +7 more
doaj   +1 more source

CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma

Journal of experimental & clinical cancer research : CR, 2020
Mounting evidence suggests that solid tumors display the features of collective invasion, however, the molecular mechanisms are far from clear.
Shi-Jie Wang, D. Chao, Wei Wei, Gang Nan, Jia-Yue Li, Fen-Ling Liu, Ling Li, Jian-Li Jiang, H. Cui, Zhi-Nan Chen   +9 more
semanticscholar   +1 more source

Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]

, 2020
Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I, Tabish, Tanveer A, Whatmore, Jacqueline L, Zhang, Shaowei   +3 more
core   +2 more sources

Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin [PDF]

, 2002
Besides its physiological role in lysosomal protein breakdown, extralysosomal cathepsin B has recently been implicated in apoptotic cell death. Highly specific irreversible cathepsin B inhibitors that are readily cellpermeant should be useful tools to ...
Assfalg-Machleidt, Irmgard, Deluca, Dominga, Höhneke, Clara, Machleidt, Werner, Schaschke, Norbert, Sommerhoff, Christian P.   +5 more
core   +1 more source