Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH [PDF]
, 2006 Our in vitro studies support a functional link between the induction of cathepsin B gene expression and the catabolic restructuring associated with myotube formation during myogenesis in vivo.
Cavallo-Medved, Dora +5 more
core +3 more sources
Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis.
PLoS ONE, 2012 Chronic HIV infection leads to the development of cognitive impairments, designated as HIV-associated neurocognitive disorders (HAND). The secretion of soluble neurotoxic factors by HIV-infected macrophages plays a central role in the neuronal ...
Eillen J Rodriguez-Franco +8 more
doaj +1 more source
Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I. [PDF]
, 2016 BackgroundCardiovascular disease, a progressive manifestation of α-L-iduronidase deficiency or mucopolysaccharidosis type I, continues in patients both untreated and treated with hematopoietic stem cell transplantation or intravenous enzyme replacement ...
Dickson, Patricia I +7 more
core +7 more sources
Frontiers in Surgery, 2018 AimWe have previously identified and characterized cancer stem cell (CSC) subpopulations in liver metastasis from colon adenocarcinoma (LMCA). In this study we investigated the expression and localization of cathepsins B, D and G, in relation to these ...
Shreeja Mehrotra +9 more
doaj +1 more source
Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis [PDF]
, 2015 International audienceAbstractThe activity of cysteine cathepsin B increased markedly in lung homogenates and in bronchoalveolar lavage fluids (BALF) of the mouse model of bleomycin-induced lung fibrosis after 14 days of challenge.
Couillin, Isabelle +7 more
core +3 more sources
Expression of a barley cystatin gene in maize enhances resistance against phytophagous mites by altering their cysteine-proteases [PDF]
, 2011 Phytocystatins are inhibitors of cysteine-proteases from plants putatively involved in plant defence based on their capability of inhibit heterologous enzymes.
A Kiggundu +49 more
core +2 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on CTSB (cathepsin B), with data on DNA, on the protein encoded, and where the gene is implicated.
Jevnikar, Z, Kos, J
openaire +2 more sources
Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging
Neural Regeneration Research, 2019 Interleukin-1β is a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer’s disease, Parkinson’s disease, stroke and persistent pain.
H. Nakanishi
semanticscholar +1 more source
Bone Microenvironment Modulates Expression and Activity of Cathepsin B in Prostate Cancer
Neoplasia: An International Journal for Oncology Research, 2005 Prostate cancers metastasize to bone leading to osteolysis. Here we assessed proteolysis of DOcollagen I (a bone matrix protein) and, for comparison, DO-collagen IV, by living human prostate carcinoma cells in vitro.
Izabela Podgorski +6 more
doaj +1 more source
Gastroenterology, 2017 BACKGROUND & AIMS: Acute pancreatitis is characterized by premature intracellular activation of digestive proteases within pancreatic acini and a consecutive systemic inflammatory response.
M. Sendler +12 more
semanticscholar +1 more source