Results 31 to 40 of about 13,268,265 (360)
ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease [PDF]
EBioMedicine, Elsevier, 2016, 9, pp.278-292, 2019 Although several ADAMs (A disintegrin-like and metalloproteases) have been shown to contribute to the amy-loid precursor protein (APP) metabolism, the full spectrum of metalloproteases involved in this metabolism remains to be established. Transcriptomic analyses centred on metalloprotease genes unraveled a 50% decrease in ADAM30 expression that ...
arxiv +1 more source
Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies [PDF]
Biological Chemistry, 2014 Abstract Cathepsin B has been demonstrated to be involved in several proteolytic processes that support tumor progression and metastasis and neurodegeneration. To further clarify its role, defined monoclonal antibodies are needed.
Weber, Ekkehard +7 more
openaire +4 more sources
Immune Mechanisms Involved in Schistosoma mansoni-Cathepsin B Vaccine Induced Protection in Mice
Frontiers in Immunology, 2018 A vaccine against schistosomiasis would contribute to a long-lasting decrease in disease spectrum and transmission. Our previous protection studies in mice using Schistosoma mansoni Cathepsin B (Sm-Cathepsin B) resulted in 59 and 60% worm burden ...
Alessandra Ricciardi +7 more
doaj +1 more source
Molecules, 2023 TMAO is a new risk biomarker for cardiovascular disease. With trimethylammonium as its main chemical skeleton, TMAO is structurally similar to many endogenous metabolites, such as acetylcholine, carnitine, phosphorylcholine, etc. The mechanism of TMAO on
Dongyu Lei +6 more
doaj +1 more source
Clinical and Experimental Dental Research, Volume 8, Issue 6, Page 1638-1644, December 2022., 2022 Abstract Objective The aim of this study was to evaluate and compare the effects of chlorhexidine, quercetin, and α‐tocopherol on the shear bond strength of universal adhesives in the short (24h) and long term (6 months). Material and Methods Ninety‐six extracted sound molars were collected and divided randomly into four groups: control (no treatment),
Marzieh Moradian +3 more
wiley +1 more source
Frontiers in Microbiology, 2023 Tomato disease is an important disease affecting agricultural production, and the combined infection of tomato chlorosis virus (ToCV) and tomato yellow leaf curl virus (TYLCV) has gradually expanded in recent years, but no effective control method has ...
Ding-Yi-Hui Lu +17 more
doaj +1 more source
Definitions, 2020 Cathepsin B (339 aa, ~38 kDa) is encoded by the human CTSB gene. This protein plays a role in proteolysis, immunity and the regulation of apoptosis.
semanticscholar +1 more source
Antigen targeting to dendritic cells: Still a place in future immunotherapy?
European Journal of Immunology, Volume 52, Issue 12, Page 1909-1924, December 2022., 2022 Dendritic cell‐based immunotherapy is a promising vaccination strategy to treat infectious diseases, autoimmunity, and cancer. In this review, we present an overview on the current state of antigen targeting approaches via C‐type lectin receptors, with an outlook on future developments and potential for clinical translation.
Patrizia Stoitzner +4 more
wiley +1 more source
Cell Proliferation, 2018 The non‐canonical inflammasome pathway was described which engages caspase‐11 to mediate pyroptosis and the subsequent release of IL‐1α, IL‐1β and IL‐18 in TLR4‐independent way.
Nan Chen +5 more
semanticscholar +1 more source
European Journal of Immunology, Volume 53, Issue 1, January 2023., 2023 Neutrophils play a role in the immunopathology SARS‐CoV‐2 infection by triggering the formation of NETs, producing cytokines including interleukin‐8 (CXCL8), and mediating the recruitment of other immune cells to regulate inflammation, which can lead to ARDS.
Maria Candida Cesta +8 more
wiley +1 more source