Cathepsin D—Managing the Delicate Balance [PDF]
Pharmaceutics, 2021 Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin D manages protein turnover degrading misfolded and aggregated proteins and favors apoptosis in the case of proteostasis disruption.
Olja Mijanovic +9 more
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Folia Histochemica et Cytobiologica, 2008 A literature survey was performed of human cathepsin D gene, cathepsin D biosynthesis, posttranslatory modifications, transport within the cell, substrate specificity and catalytic effect.
Marek Gacko +3 more
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Folia Histochemica et Cytobiologica, 2007 Inhibitors of cathepsin D belong to chemical compounds that estrify carboxyl groups of the Asp33 and Asp231residues of its catalytic site, penta-peptides containing statin, i.e.
M. Gacko +3 more
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Cathepsin D mediates tachykinin-induced secondary follicle growth independent of the hypothalamic–pituitary–gonadal axis in mice [PDF]
Frontiers in EndocrinologyBackgroundCathepsin D is an aspartic protease responsible for the proteolytic processing of vitellogenin at the early stages of folliculogenesis in oviparous vertebrates.
Tsuyoshi Kawada +3 more
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A New Cathepsin D Targeting Drug Delivery System Based on Immunoliposomes Functionalized with Lipidated Pepstatin A [PDF]
Pharmaceutics, 2023 Cathepsin D is an aspartic protease and one of the most abundant proteases. It is overexpressed in many cancers and plays an important role in tumor development, progression, and metastasis.
Andreja Kozak +5 more
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Cathepsin D elevates the fibrocalcific activity in human aortic valve cells through the ERK1/2-Sox9 pathway [PDF]
Frontiers in Cardiovascular MedicineBackgroundHuman Aortic valve interstitial cells (AVICs) from calcific aortic valve disease (CAVD)-affected valves exhibit elevated fibrocalcific activity although the underlying mechanism remains incompletely understood.
Qingzhou Yao +6 more
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A fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages [PDF]
Communications Chemistry, 2023 Cathepsin D is a protease that is an effector in the immune response of macrophages, yet to date, only a limited number of probes have been developed for its detection. Herein, we report a water soluble, highly sensitive, pH insensitive fluorescent probe
Maria Rodriguez-Rios +6 more
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Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia [PDF]
Reproductive Biology and Endocrinology, 2023 Background Cathepsin C (Cat C) is involved in the inflammatory-immune system and can be degraded by cathepsin D (Cat D). Preeclampsia (PE) and the inflammation-immunity relationship is currently a hot research topic, but there are still few studies.
Jingzhe Song +4 more
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Association of LVV-Hemorphin-7 with Sepsis and Shock: Roles of Cathepsin D and G in Hemoglobin Metabolism in a Prospective ICU Cohort Study [PDF]
BiomedicinesBackground: Sepsis is a leading cause of mortality in intensive care units (ICUs). Cell-free hemoglobin (CFH) released during sepsis interacts with lysosomal enzymes from neutrophils and macrophages.
Yao-Kuang Wu +5 more
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Molecules, 2023 In this study, cathepsin D was oxidized in vitro with different concentrations of H2O2, and the activity, structure, and extent of myofibrillar protein degradation by oxidized cathepsin D were evaluated. The sulfhydryl content of cathepsin D decreased to
Mengjie Ma +5 more
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