Cathepsin D—Managing the Delicate Balance [PDF]
Pharmaceutics, 2021 Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin D manages protein turnover degrading misfolded and aggregated proteins and favors apoptosis in the case of proteostasis disruption.
Olja Mijanovic +9 more
doaj +5 more sources
Folia Histochemica et Cytobiologica, 2008 A literature survey was performed of human cathepsin D gene, cathepsin D biosynthesis, posttranslatory modifications, transport within the cell, substrate specificity and catalytic effect.
Marek Gacko +3 more
doaj +4 more sources
Folia Histochemica et Cytobiologica, 2007 Inhibitors of cathepsin D belong to chemical compounds that estrify carboxyl groups of the Asp33 and Asp231residues of its catalytic site, penta-peptides containing statin, i.e.
M. Gacko +3 more
doaj +4 more sources
Cathepsin D mediates tachykinin-induced secondary follicle growth independent of the hypothalamic–pituitary–gonadal axis in mice [PDF]
Frontiers in EndocrinologyBackgroundCathepsin D is an aspartic protease responsible for the proteolytic processing of vitellogenin at the early stages of folliculogenesis in oviparous vertebrates.
Tsuyoshi Kawada +3 more
doaj +2 more sources
Oxidation of Cathepsin D by Hydroxy Radical: Its Effect on Enzyme Structure and Activity against Myofibrillar Proteins Extracted from Coregonus peled [PDF]
Molecules, 2023 In this study, cathepsin D was oxidized in vitro with different concentrations of H2O2, and the activity, structure, and extent of myofibrillar protein degradation by oxidized cathepsin D were evaluated. The sulfhydryl content of cathepsin D decreased to
Mengjie Ma +5 more
doaj +2 more sources
A New Cathepsin D Targeting Drug Delivery System Based on Immunoliposomes Functionalized with Lipidated Pepstatin A [PDF]
Pharmaceutics, 2023 Cathepsin D is an aspartic protease and one of the most abundant proteases. It is overexpressed in many cancers and plays an important role in tumor development, progression, and metastasis.
Andreja Kozak +5 more
doaj +2 more sources
Cathepsin D elevates the fibrocalcific activity in human aortic valve cells through the ERK1/2-Sox9 pathway [PDF]
Frontiers in Cardiovascular MedicineBackgroundHuman Aortic valve interstitial cells (AVICs) from calcific aortic valve disease (CAVD)-affected valves exhibit elevated fibrocalcific activity although the underlying mechanism remains incompletely understood.
Qingzhou Yao +6 more
doaj +2 more sources
Neurobiology of Disease, 2020 The presence of GBA1 gene mutations increases risk for Parkinson's disease (PD), but the pathogenic mechanisms of GBA1 associated PD remain unknown. Given that impaired α-synuclein turnover is a hallmark of PD pathogenesis and cathepsin D is a key enzyme
Shi-yu Yang +3 more
doaj +2 more sources
A fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages [PDF]
Communications Chemistry, 2023 Cathepsin D is a protease that is an effector in the immune response of macrophages, yet to date, only a limited number of probes have been developed for its detection. Herein, we report a water soluble, highly sensitive, pH insensitive fluorescent probe
Maria Rodriguez-Rios +6 more
doaj +2 more sources
Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia [PDF]
Reproductive Biology and Endocrinology, 2023 Background Cathepsin C (Cat C) is involved in the inflammatory-immune system and can be degraded by cathepsin D (Cat D). Preeclampsia (PE) and the inflammation-immunity relationship is currently a hot research topic, but there are still few studies.
Jingzhe Song +4 more
doaj +2 more sources