Results 31 to 40 of about 66,677 (282)

Estrogen-regulated proteins cathepsin D and pS2 in breast carcinoma [PDF]

Archive of Oncology, 2006
In addition to classical prognostic/predictive factors, significant biological markers have been identified to provide potentially relevant information regarding natural or clinical course of breast cancer.
Markićević Milan, Vujasinović Tijana, Nešković-Konstantinović Zora, Nikolić-Vukosavljević Dragica   +3 more
doaj   +1 more source

Identification of new biomarkers for sarcopenia and characterization of cathepsin D biomarker

JCSM Rapid Communications, 2021
Background Sarcopenia is the progressive generalized loss of skeletal muscle mass, strength, and function that occurs with aging. This study was undertaken to identify new biomarkers of sarcopenia by proteomics analysis of female sera.
Corine L'hôte, Benoît Cordier, Alain Labasse, Christelle Boileau, Bérénice Costes, Yves Henrotin   +5 more
doaj   +1 more source

The Specificity of Cathepsin D

Journal of Biological Chemistry, 1973
Abstract Bovine spleen cathepsin D has been partially purified for studies of its specificity. Isoelectric focusing of the purest preparation obtained indicated the presence of three molecular forms having approximately the same specific activity, but differing in their isoelectric points.
J B, Ferguson, J R, Andrews, I M, Voynick, J S, Fruton   +3 more
openaire   +2 more sources

Evaluation of serum cathepsin D concentrations in coronary artery disease

Indian Heart Journal, 2018
Background: Coronary artery disease (CAD) cannot be sufficiently explained by the presence of traditional risk factors. Cathepsin D has been proposed to serve as a surrogate marker of atherosclerosis but its alterations in CAD patients have not been ...
Amir Hooshang Mohammadpour, Zakieh Salehinejad, Sepideh Elyasi, Mohsen Mouhebati, Seyed Reza Mirhafez, Sara Samadi, Majid Ghayour-Mobarhan, Gordon Ferns, Amirhossein Sahebkar   +8 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Regulatory role of cathepsin D in apoptosis.

Folia Histochemica et Cytobiologica, 2007
Cathepsin D (CTSD, EC 3.4.23.5) is well known aspartyl protease. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells.
Marek Gacko, Alicja Karwowska, Lukasz Minarowski, Alina Minarowska   +3 more
doaj   +1 more source

Glycogen Synthase Kinase-3β and Caspase-2 Mediate Ceramide- and Etoposide-Induced Apoptosis by Regulating the Lysosomal-Mitochondrial Axis. [PDF]

PLoS ONE, 2016
Glycogen synthase kinase-3β (GSK-3β) regulates the sequential activation of caspase-2 and caspase-8 before mitochondrial apoptosis. Here, we report the regulation of Mcl-1 destabilization and cathepsin D-regulated caspase-8 activation by GSK-3β and ...
Chiou-Feng Lin, Cheng-Chieh Tsai, Wei-Ching Huang, Yu-Chih Wang, Po-Chun Tseng, Tsung-Ting Tsai, Chia-Ling Chen   +6 more
doaj   +1 more source

Activation of cathepsin D by glycosaminoglycans [PDF]

The FEBS Journal, 2009
We have previously shown that heparin can increase the activity of the proenzyme form of Alzheimer’s β‐site amyloid precursor protein cleaving enzyme 1 (BACE1). Cathepsin D (CD) is a member of the aspartic protease family and has sequence similarity to BACE1.
Beckman, Marie, Freeman, Craig, Small, David H, Parish, Christopher   +3 more
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Expression of Cathepsins B, D, and G in Isocitrate Dehydrogenase-Wildtype Glioblastoma

Frontiers in Surgery, 2017
AimTo investigate the expression of cathepsins B, D, and G, in relation to the cancer stem cell (CSC) subpopulations, we have previously characterized within isocitrate dehydogenase (IDH)-wildtype glioblastoma (IDHWGB).Methods3,3-Diaminobezidine (DAB ...
Sabrina P. Koh, Agadha C. Wickremesekera, Agadha C. Wickremesekera, Helen D. Brasch, Reginald Marsh, Swee T. Tan, Swee T. Tan, Tinte Itinteang   +7 more
doaj   +1 more source