Results 251 to 260 of about 11,881,546 (284)
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Molecular mechanism for the antigonococcal action of lysosomal cathepsin G
Molecular Microbiology, 1990SummaryHuman lysosomal cathepsin G (cat G) appears to be an important mediator of non‐oxidative killing of Neisseria gonorrhoeae ingested by human polymorpho‐nuclear leucocytes (PMNLs). Nearly isogenic strains of gonococci having variations in the structure of penicillin‐binding protein 2 (PBP2) also exhibit different levels of susceptibility to the ...
W M, Shafer +3 more
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Cathepsin G: the significance in rheumatoid arthritis as a monocyte chemoattractant
Rheumatology International, 2006Human cathepsin G (EC 3.4.21.20) has been reported to have the in vitro chemotactic activity for human monocytes. In this study, we examined the role of cathepsin G in monocyte involvement in joint inflammation of rheumatoid arthritis (RA) as a monocyte chemoattractant.
Junya, Miyata +8 more
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Cleavage of the Four Human IgG Subclasses with Cathepsin G
Scandinavian Journal of Immunology, 1982Cathepsin G, the chymotrypsin‐like serine proteinase from human polymorphonuclear leucocytes, cleaves human IgG. The relative susceptibilities of the four IgG subclasses to the action of this enzyme were studied kinetically and showed the following decreasing order of susceptibility: IgG3≫ IgG4>IgG1>IgG2.
A, Baici, M, Knöpfel, K, Fehr
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Inhibitors of cathepsin G: a patent review (2005 to present)
Expert Opinion on Therapeutic Patents, 2013Cathepsin G (CatG) is a neutral proteinase originating from human neutrophils. It displays a unique dual specificity (trypsin- and chymotrypsin-like); thus, its enzymatic activity is difficult to control. CatG is involved in the pathophysiology of several serious human diseases, such as chronic obstructive pulmonary disease (COPD), Crohn's disease ...
Paulina Kosikowska, Adam Lesner
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Cathepsin G Inactivates Human Protein S in vitro
Haemostasis, 2009Human polymorphonuclear leukocyte cathepsin G was used in vitro to digest human protein S. While clotting assays indicated that the proteinase induced a rapid decrease in activity, polyacrylamide gel electrophoresis-sodium dodecyl sulphate indicated the removal of a peptide of low molecular mass product protein S (des 1-40).
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Autophagy triggers CTSD (cathepsin D) maturation and localization inside cells to promote apoptosis
Autophagy, 2021Xin-Le Kang, Yu-Qin Di, Cai-Hua Chen
exaly
Sequence variant of the human cathepsin G gene
Human Genetics, 1993B, Lüdecke +3 more
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A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L
Molecules, 2020Dibyendu Dana, Sanjai Pathak
exaly