Results 241 to 250 of about 11,881,546 (284)
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Antibodies to Cathepsin G in Crohn's disease
European Journal of Clinical Investigation, 1992Abstract. Antibodies directed against antigens in human neutrophils have proved to be of great diagnostic value in certain systemic vasculitides. Recent reports have focused the attention on these antigens as targets of antibodies in sera of patients with inflammatory bowel disease. We investigated the sera drawn from 60 patients suffering from biopsy
W. J. MAYET +6 more
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New potent cathepsin G phosphonate inhibitors
Bioorganic & Medicinal Chemistry, 2008Cathepsin G is an enzyme with dual chymotrypsin and trypsin-like specificity. As a leukocyte proteinase it is involved in the early stages of the immune response. In this work the synthesis and inhibitory activity of diaryl phosphonic-type irreversible cathepsin G inhibitors are described.
Sieńczyk, Marcin +6 more
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Immunohistochemical localization of cathepsin G in human tissues
The American Journal of Surgical Pathology, 1985An antiserum to human cathepsin G has been raised in sheep and its reactivity with human tissues has been tested. The indirect immunoperoxidase staining sequence was employed and was applied to routinely processed paraffin sections. Mature granulocytes, especially those of the neutrophil variety, were intensely and consistently stained.
J, Crocker, R, Jenkins, D, Burnett
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The Hematology Journal, 2001
Preliminary studies have shown that high molecular mass kininogen (HK) inhibits cathepsin G-induced platelet activation. However, the potential mechanism underlying this inhibitory effect remains to be elucidated.Suspensions of washed and gel-filtered platelets were used in radioligand binding and aggregation studies.
T E, Selim +4 more
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Preliminary studies have shown that high molecular mass kininogen (HK) inhibits cathepsin G-induced platelet activation. However, the potential mechanism underlying this inhibitory effect remains to be elucidated.Suspensions of washed and gel-filtered platelets were used in radioligand binding and aggregation studies.
T E, Selim +4 more
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Low-Molecular-Weight Aldehyde Inhibitors of Cathepsin G
Protein & Peptide Letters, 2009A series of aldehyde inhibitors with the general formula Ac-Phe-Val-Thr-X-CHO, where X = Lys, Arg, Phe, Tyr, p-nitro-L-phenylalanine (Nif), p-amino-L-phenylalanine (Amf), p-guanidine-L-phenylalanine (Gnf), pyridyl-L-alanine (Pal), was synthesized. The starting structure of this series based on our previous work on cathepsin G chromogenic substrates ...
Adam Lesner +4 more
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1981
Publisher Summary This chapter presents the procedure for purification and assaying of cathepsin G. Cathepsin G is purified from human neutrophil leukocytes. Cathepsin G is eluted from the carboxymethyl-cellulose column at a higher salt concentration than the elastase.
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Publisher Summary This chapter presents the procedure for purification and assaying of cathepsin G. Cathepsin G is purified from human neutrophil leukocytes. Cathepsin G is eluted from the carboxymethyl-cellulose column at a higher salt concentration than the elastase.
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Normal Neutrophil Function in Cathepsin G-Deficient Mice
Blood, 1999Cathepsin G is a neutral serine protease that is highly expressed at the promyelocyte stage of myeloid development. We have developed a homologous recombination strategy to create a loss-of-function mutation for murine cathepsin G. Bone marrow derived from mice homozygous for this mutation had no detectable cathepsin G protein or activity, indicating ...
D M, MacIvor +5 more
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Defensins- and cathepsin G-ANCA in systemic lupus erythematosus
Rheumatology International, 2006In this study, we examined the content of antineutrophil cytoplasmic antibodies (ANCA) against defensins and cathepsin G in sera from systemic lupus erythematosus (SLE) patients and their significance in estimating the activity of SLE. Defensins- and cathepsin G-ANCA in sera from 28 patients with SLE, eight patients with rheumatoid arthritis (RA) and ...
Hiroyuki, Tamiya +8 more
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Neutrophil collagenase activation: The role of oxidants and cathepsin G
Agents and Actions, 1991The events leading to neutrophil collagenase activation in vivo were analyzed using phorbol myristate acetate (PMA) stimulated neutrophil supernatant. Under the conditions when this supernatant was incubated with the serine proteinase inhibitor, phenylmethylsulfonyl fluoride (PMSF), and then treated with the oxidant, hypochlorous acid (HOCl ...
C, Capodici, R A, Berg
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Digestion of human immunoglobulin G by bovine cathepsin B1
Immunochemistry, 1976Abstract 1. (1) Bovine cathepsin B1 is capable of breaking down human IgG in vitro at pH 4,6, 6.0 and 7.4. 2. (2) Due to high stability of cathepsin B1 at acid pH, prolonged digestion of IgG especially at pH 4.6 was possible and resulted in most extensive breakdown of IgG. 3.
H, Menninger +3 more
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