Results 71 to 80 of about 11,881,546 (284)

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Expression and Localization of Cathepsins B, D, and G in Two Cancer Stem Cell Subpopulations in Moderately Differentiated Oral Tongue Squamous Cell Carcinoma

Frontiers in Medicine, 2017
AimWe have previously demonstrated the putative presence of two cancer stem cell (CSC) subpopulations within moderately differentiated oral tongue squamous cell carcinoma (MDOTSCC), which express components of the renin–angiotensin system (RAS).
Therese Featherston, Reginald Walter Marsh, Reginald Walter Marsh, Bede van Schaijik, Helen D. Brasch, Swee T. Tan, Swee T. Tan, Tinte Itinteang   +7 more
doaj   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. [PDF]

, 2011
Behavioral endophenotypes are determined by a multitude of counteracting but precisely balanced molecular and physiological mechanisms. In this study, we aim to identify potential novel molecular targets that contribute to the multigenic trait "anxiety".
Holsboer, Florian, Pütz Benno, Graf Cornelia, Peters, C., Bunck, Mirjam, Rieder, G., Steiner, Andrea, Baur Laura A., Mirjam Bunck, Markus Panhuysen, Rieder, Gabriele, Benno Pütz, Gabriele Rieder, Pütz, Benno, Claudia Kühne, Czibere Ludwig, Deussing, Jan, Laura A Baur, Weber Peter, Bunck, M., Peters, Christoph, Holsboer Florian, Graf, C., Czibere, L., Gemmeke, K., Cornelia Graf, Nafees Ahmad, Laura A. Baur, Widner, R., Graf, Cornelia, Hambsch Boris, Wittmann, A., Hambsch, B., Christoph Peters, Steiner Andrea, Peters Christoph, Weber, Peter, Ahmad, Nafees H.M., Wittmann, Anke, Kühne, C., Widner Regina, Panhuysen Markus, Landgraf Rainer, Reinheckel Thomas, Ahmad, N., Katja Gemmeke, Bunck Mirjam, Ludwig Czibere, Ahmad Nafees, Boris Hambsch, Wittmann Anke, Peter Weber, Deussing, Jan M., Rieder Gabriele, Holsboer, F., Panhuysen, Markus, Andrea Steiner, Reinheckel, Thomas, Kühne Claudia, Hambsch, Boris, Gemmeke Katja, Baur, L., Kühne, Claudia, Weber, P., Gemmeke, Katja, Thomas Reinheckel, Czibere, Ludwig, Jan M Deussing, Widner, Regina, Deussing, J., Ahmad, Nafees, Rainer Landgraf, Anke Wittmann, Pütz, B., Landgraf, R., Reinheckel, T., Florian Holsboer, Baur, Laura A., Landgraf, Rainer, Deussing Jan M., Panhuysen, M., Jan M. Deussing, Steiner, A., Regina Widner   +83 more
core   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Neutrophil Cathepsin G and Thrombosis in COVID-19

Circulation Research
No abstract ...
Francesco Violi, Simona Bartimoccia, Roberto Cangemi, Cristina Nocella, Alessandra D'Amico, Alessandra Oliva, Mario Venditti, Francesco Pugliese, Claudio Maria Mastroianni, Lorenzo Ridola, Miriam Lichtner, Vincenzo Cardinale, Domenico Alvaro, Vittoria Cammisotto, Valentina Castellani, Pasquale Pignatelli, Roberto Carnevale   +16 more
openaire   +2 more sources

Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G

PLOS ONE, 2016
Protease-mediated degradation of proteins is critical in a plethora of physiological processes. Neutrophils secrete serine proteases including cathepsin G (CatG), neutrophile elastase (NE), and proteinase 3 (PR3) together with lactoferrin (LF) as a first cellular immune response against pathogens.
Eipper, S., Steiner, R., Lesner, A., Sienczyk, M., Palesch, D., Halatsch, M., Zaczynska, E., Heim, C., Hartmann, M., Zimecki, M., Wirtz, C., Burster, T.   +11 more
openaire   +5 more sources

Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Lymphocyte activating action of cathepsin G.

Ensho, 1991
Cathepsin G is one of serine proteases with chymotrypsin-like proteolytic activity and known to exist in neutrophils and spleens. We purified the protease from human bone marrow cells by extraction with 1 M potassium phosphate buffer (pH 7.0) and ap-plying to column chromatography of DEAF-cellulose, Sephadex G-100, CM-cellulose, and Mono-S.
Hase, Tomomi, Aoki, Yosuke
openaire   +2 more sources