Results 61 to 70 of about 11,881,546 (284)

The Control of Neutrophil Chemotaxis by Inhibitors of Cathepsin G and Chymotrypsin [PDF]

Journal of Biological Chemistry, 1995
Neutrophil chemotaxis plays an important role in the inflammatory response and when excessive or persistent may augment tissue damage. The effects of inhibitors indicated the involvement of one or more serine proteinases in human neutrophil migration and shape change in response to a chemoattractant.
D A, Lomas, S R, Stone, C, Llewellyn-Jones, M T, Keogan, Z M, Wang, H, Rubin, R W, Carrell, R A, Stockley   +7 more
openaire   +2 more sources

Purification and N-terminal amino-acid sequence analysis of rabbit neutrophil cathepsin G

, 1995
Cathepsin G was isolated from granules of rabbit bloodstream leukocytes and purified to apparent homogeneity by a multi-step procedure consisting of ammonium sulphate precipitation, affinity chromatography on elastin-Sepharose, and finally by ion ...
Annalisa Santucci, LUNGARELLA, G., Giuseppe Lungarella, Eleonora Cavarra, CAVARRA, E., SANTUCCI, A.   +5 more
core   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells. [PDF]

, 2009
Recently it has been reported that a cathepsin B inhibitor, CA-074Me, attenuates ecotropic murine leukemia virus (Eco-MLV) infection in NIH3T3 cells, suggesting that cathepsin B is required for the Eco-MLV infection.
Oishi, Kazunori, Yamamoto, Naoki, Tsutomu Mizota, Kazunori Oishi, Nobuhiko Katunuma, Kensuke Goto, Minematsu, Kazuo, Goto, Kensuke, Haruka Kamiyama, Naoki Yamamoto, Hiroaki Yoshii, Kubo, Yoshinao, Katunuma, Nobuhiko, Yoshii, Hiroaki, Kamiyama, Haruka, Mizota, Tsutomu, Kazuo Minematsu, Yoshinao Kubo   +17 more
core   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

The Influence of the Type of Dry-Cured Italian PDO Ham on Cathepsin B Activity Trend during Processing

Foods, 2021
Cathepsin B activity was measured during processing in hams originating from the main Italian prosciutto PDOs: Parma, San Daniele and Toscano. Sixty-five heavy pig thighs, from sixty-five Italian large white x Italian Landrace pigs bred and slaughtered ...
Edi Piasentier, Nicoletta Pizzutti, Giovanna Lippe   +2 more
doaj   +1 more source

Neutrophil cathepsin G increases permeability of cultured type II pneumocytes

, 1988
Neutrophils contribute to inflammatory injury in some types of acute and chronic lung disease. Among the injurious agents released by activated neutrophils are cationic proteins such as cathepsin G that may contribute to edema formation.
T. Rochat, G. W. Hunninghake, J. Casale, M. W. Peterson   +3 more
core   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Cancer Stem Cells in Head and Neck Cutaneous Squamous Cell Carcinoma Express Cathepsins

Plastic and Reconstructive Surgery, Global Open, 2020
Background:. Cancer stem cell (CSC) subpopulations within moderately differentiated head and neck cutaneous squamous cell carcinoma (MDHNcSCC) express the components of the renin–angiotensin system (RAS).
Therese Featherston, BBiomedSc(Hons), Helen D. Brasch, MBChB, FRCPA, Sam D. Siljee, MBChB, Bede van Schaijik, BTech(Hons), Josie Patel, MSc, Jennifer de Jongh, BBiomedSc, Reginald W. Marsh, PhD, Tinte Itinteang, MBBS, PhD, Swee T. Tan, MBBS, FRACS, PhD   +8 more
doaj   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source