Results 1 to 10 of about 623 (108)
Cathepsins in neuronal plasticity
Neural Regeneration Research, 2021 Proteases comprise a variety of enzymes defined by their ability to catalytically hydrolyze the peptide bonds of other proteins, resulting in protein lysis.
Amanda Phuong Tran, Jerry Silver
doaj +4 more sources
Expression of Cathepsins B, D, and G in Extracranial Arterio-Venous Malformation
Frontiers in Surgery, 2021 Objectives: We have previously identified a population of cells that expressed stemness-associated markers in extracranial arterio-venous malformation (AVM) and demonstrated expression of cathepsins B, D, and G on embryonic stem cell (ESC)-like ...
Lauren Hansen +8 more
doaj +1 more source
Biomedicines, 2022 Cathepsins are lysosomal proteases that are essential to maintain cellular physiological homeostasis and are involved in multiple processes, such as immune and energy regulation.
Hester van Mourik +4 more
doaj +1 more source
Frontiers in Immunology, 2021 Cysteine cathepsins are primarily involved in the degradation and recycling of proteins in endo-lysosomal compartments but are also gaining recognition as pivotal proteolytic contributors to various immune functions.
Milica Perišić Nanut +4 more
doaj +1 more source
Marine Drugs, 2022 Cathepsins are lysosomal cysteine proteases belonging to the papain family and play crucial roles in intracellular protein degradation/turnover, hormone maturation, antigen processing, and immune responses.
Yuqing Li +7 more
doaj +1 more source
Cathepsins B, D, and G Are Expressed in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma
Frontiers in Oncology, 2021 AimWe have previously demonstrated the presence of two cancer stem cell (CSC) subpopulations within metastatic head and neck cutaneous squamous cell carcinoma (mHNcSCC) expressing components of the renin-angiotensin system (RAS), which promotes ...
Felix Humphries +8 more
doaj +1 more source
Cysteine Cathepsins and Their Prognostic and Therapeutic Relevance in Leukemia
Annals of the National Academy of Medical Sciences (India), 2021 Cysteine cathepsins are lysosomal proteases that require Cys-His ion pair in their catalytic site for enzymatic activity. While their aberrant expression and oncogenic functions have been widely reported in solid tumors, recent findings suggest that ...
Mohit Arora +2 more
doaj +1 more source
Cancer Stem Cells in Head and Neck Cutaneous Squamous Cell Carcinoma Express Cathepsins
Plastic and Reconstructive Surgery, Global Open, 2020 Background:. Cancer stem cell (CSC) subpopulations within moderately differentiated head and neck cutaneous squamous cell carcinoma (MDHNcSCC) express the components of the renin–angiotensin system (RAS).
Therese Featherston, BBiomedSc(Hons) +8 more
doaj +1 more source
In silico identification of potential natural product inhibitors of human proteases key to SARS-CoV-2 infection [PDF]
Molecules 2020, 25(17), 3822, 2020 Presently, there are no approved drugs or vaccines to treat COVID-19 which has spread to over 200 countries and is responsible for over 3,65,000 deaths worldwide. Recent studies have shown that two human proteases, TMPRSS2 and cathepsin L, play a key role in host cell entry of SARS-CoV-2.
arxiv +1 more source
Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose. [PDF]
PLoS ONE, 2015 Autophagy is a lysosomal degradative pathway that plays an important role in maintaining cellular homeostasis. We previously showed that the inhibition of autophagy causes pancreatic β-cell apoptosis, suggesting that autophagy is a protective mechanism ...
Minjeong Jung +4 more
doaj +1 more source