Results 1 to 10 of about 84,247 (372)

Cathepsins in neuronal plasticity

Neural Regeneration Research, 2021
Proteases comprise a variety of enzymes defined by their ability to catalytically hydrolyze the peptide bonds of other proteins, resulting in protein lysis.
Amanda Phuong Tran, Jerry Silver
doaj   +2 more sources

Shaping the Immune Response: Cathepsins in Virus-Dendritic Cell Interactions [PDF]

Cells
Dendritic cells (DCs) are among the first immune cells to detect viral invasion and play a central role in initiating and shaping antiviral immune responses.
Adrianna Niedzielska, Magdalena Bossowska-Nowicka, Zuzanna Biernacka, Karolina Gregorczyk-Zboroch, Felix N. Toka, Lidia Szulc-Dąbrowska   +5 more
doaj   +2 more sources

Targeting Cathepsins in Neurodegeneration: Biochemical Advances [PDF]

Biomedicines
Background/Objectives: Cathepsins, lysosomal proteases crucial for neuronal proteostasis, mediate the clearance of misfolded and aggregated proteins. Their dysregulation is implicated in neurodegenerative and neuropsychiatric disorders such as Alzheimer ...
Francesca Di Matteo, Mariapia Vietri, Simone D’Alessio, Tania Ciaglia, Erica Federica Vestuto, Giacomo Pepe, Ornella Moltedo, Veronica Di Sarno, Simona Musella, Carmine Ostacolo, Fabio Cominelli, Pietro Campiglia, Alessia Bertamino, Maria Rosaria Miranda, Vincenzo Vestuto   +14 more
doaj   +2 more sources

Expression of Cathepsins B, D, and G in Extracranial Arterio-Venous Malformation

Frontiers in Surgery, 2021
Objectives: We have previously identified a population of cells that expressed stemness-associated markers in extracranial arterio-venous malformation (AVM) and demonstrated expression of cathepsins B, D, and G on embryonic stem cell (ESC)-like ...
Lauren Hansen, Helen D. Brasch, Erin Paterson, Josie Patel, Nicholas Bockett, Paul F. Davis, Swee T. Tan, Swee T. Tan, Swee T. Tan   +8 more
doaj   +1 more source

All Roads Lead to Cathepsins: The Role of Cathepsins in Non-Alcoholic Steatohepatitis-Induced Hepatocellular Carcinoma

Biomedicines, 2022
Cathepsins are lysosomal proteases that are essential to maintain cellular physiological homeostasis and are involved in multiple processes, such as immune and energy regulation.
Hester van Mourik, Mengying Li, Sabine Baumgartner, Jan Theys, Ronit Shiri-Sverdlov   +4 more
doaj   +1 more source

The Role of Cysteine Peptidases in Hematopoietic Stem Cell Differentiation and Modulation of Immune System Function

Frontiers in Immunology, 2021
Cysteine cathepsins are primarily involved in the degradation and recycling of proteins in endo-lysosomal compartments but are also gaining recognition as pivotal proteolytic contributors to various immune functions.
Milica Perišić Nanut, Urša Pečar Fonović, Tanja Jakoš, Janko Kos, Janko Kos   +4 more
doaj   +1 more source

Cathepsins B, D, and G Are Expressed in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma

Frontiers in Oncology, 2021
AimWe have previously demonstrated the presence of two cancer stem cell (CSC) subpopulations within metastatic head and neck cutaneous squamous cell carcinoma (mHNcSCC) expressing components of the renin-angiotensin system (RAS), which promotes ...
Felix Humphries, Bridget Chang-McDonald, Josie Patel, Nicholas Bockett, Erin Paterson, Paul F. Davis, Swee T. Tan, Swee T. Tan, Swee T. Tan   +8 more
doaj   +1 more source

Genome-Wide Identification, Evolutionary Analysis, and Expression Patterns of Cathepsin Superfamily in Black Rockfish (Sebastes schlegelii) following Aeromonas salmonicida Infection

Marine Drugs, 2022
Cathepsins are lysosomal cysteine proteases belonging to the papain family and play crucial roles in intracellular protein degradation/turnover, hormone maturation, antigen processing, and immune responses.
Yuqing Li, Xingchun Li, Pei Zhang, Defeng Chen, Xinran Tao, Min Cao, Chao Li, Qiang Fu   +7 more
doaj   +1 more source

Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]

, 2020
Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I, Tabish, Tanveer A, Whatmore, Jacqueline L, Zhang, Shaowei   +3 more
core   +2 more sources

Cancer Stem Cells in Head and Neck Cutaneous Squamous Cell Carcinoma Express Cathepsins

Plastic and Reconstructive Surgery, Global Open, 2020
Background:. Cancer stem cell (CSC) subpopulations within moderately differentiated head and neck cutaneous squamous cell carcinoma (MDHNcSCC) express the components of the renin–angiotensin system (RAS).
Therese Featherston, BBiomedSc(Hons), Helen D. Brasch, MBChB, FRCPA, Sam D. Siljee, MBChB, Bede van Schaijik, BTech(Hons), Josie Patel, MSc, Jennifer de Jongh, BBiomedSc, Reginald W. Marsh, PhD, Tinte Itinteang, MBBS, PhD, Swee T. Tan, MBBS, FRACS, PhD   +8 more
doaj   +1 more source