Results 11 to 20 of about 84,247 (372)
The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management
Cells, 2020 Cathepsins are the most abundant lysosomal proteases that are mainly found in acidicendo/lysosomal compartments where they play a vital role in intracellular protein degradation,energy metabolism, and immune responses among a host of other functions. The
Tulasi Yadati +3 more
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Frontiers in Immunology, 2022 Cathepsins were first described, as endolysosomal proteolytic enzymes in reference to the organelles where they degrade the bulk of endogenous and exogenous substrates in a slightly acidic environment.
Elsa Anes +3 more
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Cathepsins Trigger Cell Death and Regulate Radioresistance in Glioblastoma
Cells, 2022 Treatment of glioblastoma (GBM) remains very challenging, and it is particularly important to find sensitive and specific molecular targets. In this work, we reveal the relationship between the expression of cathepsins and radioresistance in GBM.
Xiaofeng Ding +4 more
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Cysteine Cathepsins and Their Extracellular Roles: Shaping the Microenvironment
Cells, 2019 For a long time, cysteine cathepsins were considered primarily as proteases crucial for nonspecific bulk proteolysis in the endolysosomal system. However, this view has dramatically changed, and cathepsins are now considered key players in many important
Eva Vidak +3 more
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New Insights into the Role of Cysteine Cathepsins in Neuroinflammation
Biomolecules, 2021 Neuroinflammation, which is mediated by microglia and astrocytes, is associated with the progression of neurodegenerative diseases. Increasing evidence shows that activated microglia induce the expression and secretion of various lysosomal cathepsins ...
Anja Pišlar, Lara Bolčina, Janko Kos
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The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease
Frontiers in Cell and Developmental Biology, 2017 Kidney disease is worldwide the 12th leading cause of death affecting 8–16% of the entire population. Kidney disease encompasses acute (short-lasting episode) and chronic (developing over years) pathologies both leading to renal failure.
Pasquale Cocchiaro +14 more
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Cathepsins in Bacteria-Macrophage Interaction: Defenders or Victims of Circumstance?
Frontiers in Cellular and Infection Microbiology, 2020 Macrophages are the first encounters of invading bacteria and are responsible for engulfing and digesting pathogens through phagocytosis leading to initiation of the innate inflammatory response.
Lidia Szulc-Dąbrowska +4 more
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The Role of Cathepsins in Memory Functions and the Pathophysiology of Psychiatric Disorders
Frontiers in Psychiatry, 2020 Cathepsins are proteases with functions in cellular homeostasis, lysosomal degradation and autophagy. Their role in the development of neurodegenerative diseases has been extensively studied.
Christine Niemeyer +7 more
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Redundancy between Cysteine Cathepsins in Murine Experimental Autoimmune Encephalomyelitis. [PDF]
PLoS ONE, 2015 The cysteine cathepsins B, S, and L are functionally linked to antigen processing, and hence to autoimmune disorders such as multiple sclerosis. Stemming from several studies that demonstrate that mice can be protected from experimental autoimmune ...
Euan Ramsay Orr Allan +1 more
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Expression of Cathepsins B, D and G in Infantile Hemangioma
Frontiers in Surgery, 2015 Aims: The role of the renin-angiotensin system (RAS) in the biology of infantile hemangioma (IH) represents an emerging paradigm, particularly the involvement of renin, angiotensin converting enzyme and angiotensin II.
Tinte eItinteang +6 more
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