Results 11 to 20 of about 623 (108)
The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management
Cells, 2020 Cathepsins are the most abundant lysosomal proteases that are mainly found in acidicendo/lysosomal compartments where they play a vital role in intracellular protein degradation,energy metabolism, and immune responses among a host of other functions. The
Tulasi Yadati +3 more
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Translational Neurodegeneration, 2023 Background Lysosomal dysfunction has been implicated in a number of neurodegenerative diseases such as Parkinson’s disease (PD). Various molecular, clinical and genetic studies have highlighted a central role of lysosomal pathways and proteins in the ...
Alice Drobny +11 more
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Frontiers in Immunology, 2022 Cathepsins were first described, as endolysosomal proteolytic enzymes in reference to the organelles where they degrade the bulk of endogenous and exogenous substrates in a slightly acidic environment.
Elsa Anes +3 more
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Cathepsins in oral diseases: mechanisms and therapeutic implications
Frontiers in Immunology, 2023 Cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis.
Hao Jiang +6 more
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Expression and Localization of Cathepsins B, D, and G in Dupuytren’s Disease
Plastic and Reconstructive Surgery, Global Open, 2018 Background:. The pathogenesis of Dupuytren’s disease (DD) remains unclear. An embryonic stem cell (ESC)–like population in the endothelium of the microvessels around tissues that expresses components of the renin-angiotensin system (RAS) has been ...
Kirin Tan, MB ChB +7 more
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In silico analysis of cysteine cathepsins identified from the transcriptome profile of blunt snout bream (Megalobrama amblycephala) [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2018 Cysteine cathepsins are described as lysosomal proteases with housekeeping and highly specialised functions in many organisms. In this study, cysteine cathepsins were identified from the transcriptome profile of blunt snout bream (Megalobrama ...
Ngoc Tuan Tran, Wei-Min Wang
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Cathepsins Trigger Cell Death and Regulate Radioresistance in Glioblastoma
Cells, 2022 Treatment of glioblastoma (GBM) remains very challenging, and it is particularly important to find sensitive and specific molecular targets. In this work, we reveal the relationship between the expression of cathepsins and radioresistance in GBM.
Xiaofeng Ding +4 more
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Attacking COVID-19 Progression using Multi-Drug Therapy for Synergetic Target Engagement [PDF]
Biomolecules 2021, 11(6), 787, 2020 COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population. Over the past 6 months, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, has already infected over 11.6 million (25% located in United States) and killed ...
arxiv +1 more source
The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease
Frontiers in Cell and Developmental Biology, 2017 Kidney disease is worldwide the 12th leading cause of death affecting 8–16% of the entire population. Kidney disease encompasses acute (short-lasting episode) and chronic (developing over years) pathologies both leading to renal failure.
Pasquale Cocchiaro +14 more
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Human cysteine cathepsins are not reliable markers of infection by Pseudomonas aeruginosa in cystic fibrosis. [PDF]
PLoS ONE, 2011 Cysteine cathepsins have emerged as new players in inflammatory lung disorders. Their activities are dramatically increased in the sputum of cystic fibrosis (CF) patients, suggesting that they are involved in the pathophysiology of CF.
Clément Naudin +9 more
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