Results 21 to 30 of about 623 (108)
Frontiers in Medicine, 2017 AimWe have previously demonstrated the putative presence of two cancer stem cell (CSC) subpopulations within moderately differentiated oral tongue squamous cell carcinoma (MDOTSCC), which express components of the renin–angiotensin system (RAS).
Therese Featherston +7 more
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New Insights into the Role of Cysteine Cathepsins in Neuroinflammation
Biomolecules, 2021 Neuroinflammation, which is mediated by microglia and astrocytes, is associated with the progression of neurodegenerative diseases. Increasing evidence shows that activated microglia induce the expression and secretion of various lysosomal cathepsins ...
Anja Pišlar, Lara Bolčina, Janko Kos
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Cysteine Cathepsins and Their Extracellular Roles: Shaping the Microenvironment
Cells, 2019 For a long time, cysteine cathepsins were considered primarily as proteases crucial for nonspecific bulk proteolysis in the endolysosomal system. However, this view has dramatically changed, and cathepsins are now considered key players in many important
Eva Vidak +3 more
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ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease [PDF]
EBioMedicine, Elsevier, 2016, 9, pp.278-292, 2019 Although several ADAMs (A disintegrin-like and metalloproteases) have been shown to contribute to the amy-loid precursor protein (APP) metabolism, the full spectrum of metalloproteases involved in this metabolism remains to be established. Transcriptomic analyses centred on metalloprotease genes unraveled a 50% decrease in ADAM30 expression that ...
arxiv +1 more source
Redundancy between Cysteine Cathepsins in Murine Experimental Autoimmune Encephalomyelitis. [PDF]
PLoS ONE, 2015 The cysteine cathepsins B, S, and L are functionally linked to antigen processing, and hence to autoimmune disorders such as multiple sclerosis. Stemming from several studies that demonstrate that mice can be protected from experimental autoimmune ...
Euan Ramsay Orr Allan +1 more
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THE PURIFICATION OF CATHEPSIN [PDF]
Journal of General Physiology, 1940 1. One mg. of the purified cathepsin whose preparation is described is as active as the extract of 1.3 gm. of spleen. An eightfold further purification is possible by procedures which are still being modified and so are not described in the present paper. 2.
openaire +3 more sources
Activation of NLRP3 Inflammasome by Virus-Like Particles of Human Polyomaviruses in Macrophages
Frontiers in Immunology, 2022 Viral antigens can activate phagocytes, inducing inflammation, but the mechanisms are barely explored. The aim of this study is to investigate how viral oligomeric proteins of different structures induce inflammatory response in macrophages.
Asta Lučiūnaitė +9 more
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Frontiers in Immunology, 2022 The P2X7 receptor is a critical purinergic receptor in immune cells. Its activation was associated with cathepsin release into macrophage cytosol, suggesting its involvement in lysosomal membrane permeabilization (LMP) and leakage.
Stephanie Alexia Cristina Silva Santos +10 more
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THE ESTIMATION OF CATHEPSIN WITH HEMOGLOBIN AND THE PARTIAL PURIFICATION OF CATHEPSIN [PDF]
Journal of General Physiology, 1937 An account of previous work on cathepsin may be found in the monograph of Pozzi (1935). In the hemoglobin method for the estimation of protelnase, denatured hemoglobin is digested and the digestion products not precipitable by trichloracefic acid are estimated colorimetrically.
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Marine Drugs, 2023 Nocuolin A (1), an oxadiazine, was isolated from the cyanobacterium Nostoc sp. Its chemical structure was elucidated using NMR and mass spectroscopic data. From this compound, two new oxadiazines, 3-[(6R)-5,6-dihydro-4,6-dipentyl-2H-1,2,3-oxadiazin-2-yl]-
Víctor Tena Pérez +7 more
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