Results 21 to 30 of about 84,247 (372)
Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation [PDF]
Cell Death and Disease, 2016 Sirtuin-1 (SIRT1) regulates hepatic metabolism but its contribution to NF-κB-dependent inflammation has been overlooked. Cysteine cathepsins (Cathepsin B or S, CTSB/S) execute specific functions in physiological processes, such as protein degradation ...
Colell Riera, Anna +8 more
core +2 more sources
Expression of Cathepsins B, D, and G in Isocitrate Dehydrogenase-Wildtype Glioblastoma
Frontiers in Surgery, 2017 AimTo investigate the expression of cathepsins B, D, and G, in relation to the cancer stem cell (CSC) subpopulations, we have previously characterized within isocitrate dehydogenase (IDH)-wildtype glioblastoma (IDHWGB).Methods3,3-Diaminobezidine (DAB ...
Sabrina P. Koh +7 more
doaj +2 more sources
Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells
Frontiers in Immunology, 2014 Cysteine cathepsins are lysosomal peptidases involved at different levels in the processes of the innate and adaptive immune responses. Some, such as cathepsins B, L and H are expressed constitutively in most immune cells.
Janko eKos +3 more
doaj +2 more sources
Mendelian randomization analyses explore the relationship between cathepsins and lung cancer
Communications Biology, 2023 A Mendelian randomization analysis identifies a potential causal link between cathepsin H and lung cancer risk. Lung cancer, a major contributor to cancer-related fatalities worldwide, involves a complex pathogenesis.
Jialin Li +4 more
semanticscholar +1 more source
The Key Role of Lysosomal Protease Cathepsins in Viral Infections
International Journal of Molecular Sciences, 2022 Cathepsins encompass a family of lysosomal proteases that mediate protein degradation and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are also found in the cytoplasm, nucleus, and extracellular space, where they are ...
Melania Scarcella +6 more
semanticscholar +1 more source
Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants
International Journal of Molecular Sciences, 2020 Besides their primary involvement in the recycling and degradation of proteins in endo-lysosomal compartments and also in specialized biological functions, cysteine cathepsins are pivotal proteolytic contributors of various deleterious diseases.
G. Lalmanach +5 more
semanticscholar +1 more source
Translational Neurodegeneration, 2023 Background Lysosomal dysfunction has been implicated in a number of neurodegenerative diseases such as Parkinson’s disease (PD). Various molecular, clinical and genetic studies have highlighted a central role of lysosomal pathways and proteins in the ...
Alice Drobny +11 more
doaj +1 more source
Cathepsins in oral diseases: mechanisms and therapeutic implications
Frontiers in Immunology, 2023 Cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis.
Hao Jiang +6 more
doaj +1 more source
Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose. [PDF]
PLoS ONE, 2015 Autophagy is a lysosomal degradative pathway that plays an important role in maintaining cellular homeostasis. We previously showed that the inhibition of autophagy causes pancreatic β-cell apoptosis, suggesting that autophagy is a protective mechanism ...
Minjeong Jung +4 more
doaj +1 more source
Expression and Localization of Cathepsins B, D, and G in Dupuytren’s Disease
Plastic and Reconstructive Surgery, Global Open, 2018 Background:. The pathogenesis of Dupuytren’s disease (DD) remains unclear. An embryonic stem cell (ESC)–like population in the endothelium of the microvessels around tissues that expresses components of the renin-angiotensin system (RAS) has been ...
Kirin Tan, MB ChB +7 more
doaj +1 more source