Results 21 to 30 of about 6,369 (264)

Psychopathological Concomitants and Motivations Related to Misuse of Non-Steroidal Anti-Inflammatory Drugs and Paracetamol. [PDF]

Hum Psychopharmacol
ABSTRACT Introduction Non‐steroidal anti‐inflammatory drugs (NSAIDs) and paracetamol are among the most commonly used medications worldwide. It has been suggested that the misuse of such medications is not uncommon. The objective of the present research was to explore prevalence, reported reasons and psychopathological concomitants related to NSAIDs ...
Bersani FS, Prevete E, Accinni T, Montaldo S, Pinucci I, Maraone A, Tarsitani L, Pasquini M, Imperatori C.   +8 more
europepmc   +2 more sources

The Pharmacological Profile of Second Generation Pyrovalerone Cathinones and Related Cathinone Derivative [PDF]

International Journal of Molecular Sciences, 2021
Pyrovalerone cathinones are potent psychoactive substances that possess a pyrrolidine moiety. Pyrovalerone-type novel psychoactive substances (NPS) are continuously detected but their pharmacology and toxicology are largely unknown. We assessed several pyrovalerone and related cathinone derivatives at the human norepinephrine (NET), dopamine (DAT), and
Karolina E. Kolaczynska, Jan Thomann, Marius C. Hoener, Matthias E. Liechti   +3 more
openaire   +4 more sources

Hazard Characterization of Synthetic Cathinones Using Viability, Monoamine Reuptake, and Neuronal Activity Assays

Frontiers in Neuroscience, 2020
Synthetic cathinones are the second largest class of new psychoactive substances (NPS) on the drug market. Despite the large number of different cathinones and their abundant use, hazard characterization is mainly limited to their potential to inhibit ...
Anne Zwartsen, Anne Zwartsen, Michiel E. Olijhoek, Remco H. S. Westerink, Laura Hondebrink   +4 more
doaj   +1 more source

Recent Contributions of Organic Synthesis to Forensic Science. [PDF]

Chempluschem
Forensic science is a multidisciplinary field that plays a vital role in providing scientific evidence for criminal investigations. This review highlights advances and opportunities at the interface between organic synthesis and forensic science, with applications in drug identification, forensic toxicology, and latent fingerprint detection and ...
Dos Santos Martins G, Dos Santos Dupim M, Garcia Agostinho R, Gadini Finelli F.   +3 more
europepmc   +2 more sources

Synthesis, Characterization, and Biological Effects of Chloro-Cathinones: Toxicity and Potential Neurological Impact [PDF]

International Journal of Molecular Sciences
Raquel A. Ferro, Joana Rm Silva, Celso Alves   +2 more
exaly   +2 more sources

DFT calculations as an efficient tool for prediction of Raman and infra-red spectra and activities of newly synthesized cathinones

Open Chemistry, 2020
Initially made for medical treatment for Parkinsonism, obesity, and depression, cathinones have become illegal drugs for the “recreational use”. The mechanism of action of synthetic cathinones consists of the inhibition of monoamine transporters.
Vujović Maja, Ragavendran Venkatesan, Arsić Biljana, Kostić Emilija, Mladenović Milan   +4 more
doaj   +1 more source

Molecular Docking Assessment of Cathinones as 5-HT_2AR Ligands: Developing of Predictive Structure-Based Bioactive Conformations and Three-Dimensional Structure-Activity Relationships Models for Future Recognition of Abuse Drugs

Molecules, 2023
Commercially available cathinones are drugs of long-term abuse drugs whose pharmacology is fairly well understood. While their psychedelic effects are associated with 5-HT2AR, the enclosed study summarizes efforts to shed light on the pharmacodynamic ...
Nevena Tomašević, Maja Vujović, Emilija Kostić, Venkatesan Ragavendran, Biljana Arsić, Sanja Lj. Matić, Mijat Božović, Rossella Fioravanti, Eleonora Proia, Rino Ragno, Milan Mladenović   +10 more
doaj   +1 more source

Metabolic profiling of four synthetic stimulants, including the novel indanyl-cathinone 5-PPDi, after human hepatocyte incubation

Journal of Pharmaceutical Analysis, 2020
Synthetic cathinones are new psychoactive substances that represent a health risk worldwide. For most of the 130 reported compounds, information about toxicology and/or metabolism is not available, which hampers their detection (and subsequent medical ...
David Fabregat-Safont, Marie Mardal, Juan V. Sancho, Félix Hernández, Kristian Linnet, María Ibáñez   +5 more
doaj   +1 more source

Comparison of six derivatizing agents for the determination of nine synthetic cathinones using gas chromatography-mass spectrometry [PDF]

, 2017
Six acylation reagents have been compared for their derivatisation potential towards nine synthetic cathinones by gas chromatography-mass spectrometry (GC-MS).
Alsenedi, Khalid A., Morrison, Calum
core   +1 more source

New psychoactive and classic substances in pooled urine samples collected at the Ultra Europe festival in Split, Croatia

Arhiv za Higijenu Rada i Toksikologiju, 2021
We believe that analysing pooled urine samples for recreational drugs used at mass events can provide useful information about trends in drug use. An opportunity arose with the Ultra Europe music festival, which is attended by more than 150,000 people ...
Sutlović Davorka, Kuret Sendi, Definis Marija   +2 more
doaj   +1 more source