Results 121 to 130 of about 64,095 (292)

Genetic risk factors associated with ocular perfusion pressure in primary open-angle glaucoma

Human Genomics
Background Primary open-angle glaucoma (POAG) is the leading cause of irreversible vision loss. However, its genetic risk factors, such as the vascular hypothesis of POAG, remain unclear.
Heejin Jin, Je Hyun Seo, Young Lee, Sungho Won   +3 more
doaj   +1 more source

Causal mediation analysis in instrumental-variables regressions [PDF]

In this article, we describe the use of ivmediate, a new command to estimate causal mediation effects in instrumental-variables settings using the framework developed by Dippel et al. (2020, unpublished manuscript).
Dippel, Christian, Heblich, Stephan, Ferrara, Andreas   +2 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A comparison and evaluation of statistical methods for mediation analysis with mixtures of environmental exposures

BMC Medical Research Methodology
Background Environmental studies often evaluate how exposures influence health outcomes through intermediate biological processes. In practice, researchers are often interested in complex exposure mixtures rather than single agents, creating challenges ...
Sean McGrath, Yiran Wang, Yi-Ting Lin, John D. Meeker, Sung Kyun Park, Joshua L. Warren, Bhramar Mukherjee   +6 more
doaj   +1 more source

Methods in causal inference. Part 2: Interaction, mediation, and time-varying treatments

Evolutionary Human Sciences
The analysis of ‘moderation’, ‘interaction’, ‘mediation’ and ‘longitudinal growth’ is widespread in the human sciences, yet subject to confusion. To clarify these concepts, it is essential to state causal estimands, which requires the specification of ...
Joseph A. Bulbulia
doaj   +1 more source

Mediation Analysis in Experimental Research

, 2018
This chapter introduces the conceptual and statistical basics of mediation analysisin the context of experimental research. Adopting the respective terminology,mediation analysis can be referred to as an array of quantitative methods developedto ...
Koschate-Fischer, Nicole, Schwille, Elisabeth   +1 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Causal Mediation Analysis with Spatial Interference

In the causal inference framework, estimating causal effects requires specific assumptions, among which is the assumption of independence of each unit’s outcome from the treatment assigned to other units.
Giada Adelfio, Chiara Di Maria
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Causal relationships between gut microbiota, plasma metabolites, and HIV infection: insights from Mendelian randomization and mediation analysis

Virology Journal
Objective Gut dysbiosis and metabolic abnormalities have been implicated in HIV infection. However, the exact causal relationships among the gut microbiota, metabolites, and HIV infection remain poorly understood.
Jiapeng Hu, Jinxin Hu, Dan Han
doaj   +1 more source