Results 121 to 130 of about 23,676,347 (287)
BMC Medical Research MethodologyBackground Environmental studies often evaluate how exposures influence health outcomes through intermediate biological processes. In practice, researchers are often interested in complex exposure mixtures rather than single agents, creating challenges ...
Sean McGrath +6 more
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Methods in causal inference. Part 2: Interaction, mediation, and time-varying treatments
Evolutionary Human SciencesThe analysis of ‘moderation’, ‘interaction’, ‘mediation’ and ‘longitudinal growth’ is widespread in the human sciences, yet subject to confusion. To clarify these concepts, it is essential to state causal estimands, which requires the specification of ...
Joseph A. Bulbulia
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DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
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Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
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Replication Data for: Semiparametric Estimation for Causal Mediation Analysis with Multiple Causally Ordered ...
Zhou, Xiang
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Causal Mediation Analysis With Treatment Noncompliance
When evaluating a new intervention, we often seek causality, which we may estimate by the intervention's average treatment effect. When interest is in the causal mechanism, causal mediation analysis is more appropriate.
Lind, Miriam
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Clinical EpidemiologyMikkel Runason Simonsen,1,2 Eva Futtrup Maksten,1,3 Lasse Hjort Jakobsen,1 Marianne Tang Severinsen,1,3 Eldad J Dann,4 Henrik Frederiksen,5,6 Carsten Utoft Niemann,7 Judit Mészáros Jørgensen,8 Michael Roost Clausen,9 Jørn Starklint,10 Søren Paaske ...
Simonsen MR +12 more
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Virology JournalObjective Gut dysbiosis and metabolic abnormalities have been implicated in HIV infection. However, the exact causal relationships among the gut microbiota, metabolites, and HIV infection remain poorly understood.
Jiapeng Hu, Jinxin Hu, Dan Han
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FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
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Mediation Analysis in Experimental Research
, 2018 This chapter introduces the conceptual and statistical basics of mediation analysisin the context of experimental research. Adopting the respective terminology,mediation analysis can be referred to as an array of quantitative methods developedto ...
Koschate-Fischer, Nicole +1 more
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