Results 101 to 110 of about 64,095 (292)

Statistical Mediation Analysis in Regression Discontinuity Design for Causal Inference

, 2021
Regression discontinuity designs (RDDs) are the most robust quasi-experimental design, but current statistical models are limited to estimates for the simple causal relationship between only two variables: the independent and dependent variables.
Chen, Donna
core  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Immune cells mediate the effects of gut microbiota on neuropathic pain: a Mendelian randomization study

The Journal of Headache and Pain
Background The gut microbiota may be involved in neuropathic pain. However, the causal association between gut microbiota and neuropathic pain remains unclear.
Hao Pan, Cheng-xiao Liu, Hui-juan Zhu, Guang-fen Zhang   +3 more
doaj   +1 more source

Effect of the gut microbiome, plasma metabolome, peripheral cells, and inflammatory cytokines on obesity: a bidirectional two-sample Mendelian randomization study and mediation analysis

Frontiers in Immunology
BackgroundObesity is a metabolic and chronic inflammatory disease involving genetic and environmental factors. This study aimed to investigate the causal relationship among gut microbiota abundance, plasma metabolomics, peripheral cell (blood and immune ...
Ying Li, Ying Li, Ying Li, Xin Wang, Xin Wang, Xin Wang, Zitong Zhang, Zitong Zhang, Zitong Zhang, Lei Shi, Lei Shi, Lei Shi, Liang Cheng, Liang Cheng, Xue Zhang, Xue Zhang, Xue Zhang, Xue Zhang   +17 more
doaj   +1 more source

Pathway Analysis, Causal Mediation, and the Identification of Causal Mechanisms

, 2023
AbstractThis chapter presents the systematic analysis of causal mechanisms from the perspective of pathway analysis as an essential complement to conventional approaches to causation. It builds on the evidence that credible causal identification defies design-based strategies such as randomization or linear mediation analysis unless their research ...
openaire   +1 more source

A General Approach to Causal Mediation Analysis

, 2019
Traditionally in the social sciences, causal mediation analysis has been formulated, understood, and implemented within the framework of linear structural equation models.
Keele, Luke, Imai, Kosuke, Tingley, Dustin   +2 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Revisiting Mediation in the Social and Behavioral Sciences

Journal of Methods and Measurement in the Social Sciences, 2013
The process of mediation is of critical importance to the social and behavioral sciences and to evolutionary social psychology in particular. As with the concept of evolutionary adaptation, however, one can argue that causal mediation is in need of ...
Aurelio José Figueredo, Rafael Antonio Garcia, Tomás Cabeza de Baca, Jonathon Colby Gable, Dave Weise   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source