Results 91 to 100 of about 64,095 (292)

Delay and knowledge mediation in human causal reasoning [PDF]

, 2002
Contemporary theories of causal induction have focussed largely on the question of how evidence in the form of covariations between causes and effects is used to compute measures of causal strength.
Buehner, Marc
core  

Do routinely measured risk factors for obesity explain the sex gap in its prevalence? Observations from Saudi Arabia. [PDF]

, 2015
BACKGROUND: The prevalence of adult obesity is higher in women than men in most countries. However, the pathways that link female sex with excess obesity are still not fully understood. We examine whether socioeconomic and behavioural factors may mediate
Devries, Karen, George B Ploubidis, Fatima Garawi, Nasser Al-Hamdan, Uauy, Ricardo, Karen Devries, Ploubidis, George B, Al-Hamdan, Nasser, Ricardo Uauy, Garawi, Fatima   +9 more
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Associations among immunophenotype, plasma metabolites, and benign prostatic hyperplasia: a mediation Mendelian randomization study [PDF]

Yixue xinzhi zazhi
Objective To explore the potential causal relationship between immune cells, plasma metabolites and benign prostatic hyperplasia (BPH) and the mediating role of plasma metabolism by using the mediated Mendelian randomization (MR) method.
FAN Jiuming, ZHAO Yiqiao, JIA Haichang, WANG Tiankun, HAN Yutong, QIN Zihao, CHEN Ping, ZENG Xiantao   +7 more
doaj   +1 more source

Causal mediation analysis using R

, 2009
Causal mediation analysis is widely used across many disciplines to investigate possible causal mechanisms. Such an analysis allows researchers to explore various causal pathways, going beyond the estimation of simple causal effects.
Dustin Tingley, Kosuke Imai, Luke Keele
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Conditional generative adversarial networks for individualized causal mediation analysis

Journal of Causal Inference
Most classical methods popularly used in causal mediation analysis can only estimate the average causal effects and are difficult to apply to precision medicine.
Huan Cheng, Sun Rongqian, Song Xinyuan
doaj   +1 more source

Causal mediation analysis decomposition of between-hospital variance

, 2023
Causal variance decompositions for a given disease-specific quality indicator can be used to quantify differences in performance between hospitals or health care providers.
Lawson, Keith A., Saarela, Olli, Finelli, Antonio, Chen, Bo   +3 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Genetic association of serum lipids and lipid-modifying targets with endometriosis: Trans-ethnic Mendelian-randomization and mediation analysis.

PLoS ONE
BackgroundPrior observational research identified dyslipidemia as a risk factor for endometriosis (EMS) but the causal relationship remains unestablished due to inherent study limitations.MethodsGenome-wide association study data for high-density ...
Hongling Zhang, Yawei Fan, Huijun Li, Xiaoqing Feng, Daoyuan Yue   +4 more
doaj   +1 more source