Results 111 to 120 of about 64,095 (292)

mediation: R Package for Causal Mediation Analysis Dustin Tingley Harvard

, 2014
In this paper, we describe the R package mediation for conducting causal mediation analysis in applied empirical research. In many scientific disciplines, the goal of researchers is not only estimating causal effects of a treatment but also understanding
Kentaro Hirose, Luke Keele, Kosuke Imai
core  

Causal mediation analysis with multiple causally-ordered mediators [PDF]

, 2013
Symposium on Causal Mediation Analysis, Ghent 28–29 January ...
David, Leon, Rhian, Daniel, Bianca, De Stavola   +2 more
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Co-residence with children as a mediator between widowhood and loneliness in older adults

BMC Geriatrics
Background Loneliness in older adults, exacerbated by widowhood, is a significant public health concern. While widowhood can lead to changes in living arrangements, its impact on loneliness may vary across cultural contexts.
Kaishan Jiao, Xiuyun Pang, Wen Hu
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Causal Mediation Programs in R, Mplus, SAS, SPSS, and Stata

, 2020
Mediation analysis is a methodology used to understand how and why an independent variable (X) transmits its effect to an outcome (Y) through a mediator (M).
Smyth, Heather L., Valente, Matthew J., Rijnhart, Judith J.M., Muniz, Felix B., MacKinnon, David P.   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Causal relationship between GM, immune cells and esophageal adenocarcinoma: a mediation analysis based on MR

Journal of Cardiothoracic Surgery
Background Modulating the immune system represents a pivotal mechanism through which the gut microbiome (GM) exerts influence over disease progression.
Wenbo He, Mingjun Gao, Qinglin Ren, Mengmeng Wang, Siding Zhou, Qingwen Liu, Kai Chu, Yannv Qin, Yiwei Fan, Hui Zou, Yaqian Cui, Yusheng Shu, Xiaolin Wang   +12 more
doaj   +1 more source

Estimating the Bayesian posterior distribution of indirect effects in causal longitudinal mediation analysis

Many research studies aim to unveil the causal mechanism underlying a particular phenomenon; mediation analysis is increasingly used for this scope, and longitudinal data are particularly suited for mediation since they ensure the correct temporal order ...
Abbruzzo, Antonino, Di Maria, Chiara, Lovison, Gianfranco   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source