Results 111 to 120 of about 23,676,347 (287)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Sensitivity Analysis for Causal Mediation Analysis

Data and R code for "Sensitivity Analysis for Unmeasured Pretreatment Confounders in Causal Mediation Analysis with Debiased Machine ...
Xiao Liu
core  

Causal relationship between GM, immune cells and esophageal adenocarcinoma: a mediation analysis based on MR

Journal of Cardiothoracic Surgery
Background Modulating the immune system represents a pivotal mechanism through which the gut microbiome (GM) exerts influence over disease progression.
Wenbo He, Mingjun Gao, Qinglin Ren, Mengmeng Wang, Siding Zhou, Qingwen Liu, Kai Chu, Yannv Qin, Yiwei Fan, Hui Zou, Yaqian Cui, Yusheng Shu, Xiaolin Wang   +12 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

mediation: R Package for Causal Mediation Analysis Dustin Tingley Harvard

, 2014
In this paper, we describe the R package mediation for conducting causal mediation analysis in applied empirical research. In many scientific disciplines, the goal of researchers is not only estimating causal effects of a treatment but also understanding
Kentaro Hirose, Luke Keele, Kosuke Imai
core  

Genetic risk factors associated with ocular perfusion pressure in primary open-angle glaucoma

Human Genomics
Background Primary open-angle glaucoma (POAG) is the leading cause of irreversible vision loss. However, its genetic risk factors, such as the vascular hypothesis of POAG, remain unclear.
Heejin Jin, Je Hyun Seo, Young Lee, Sungho Won   +3 more
doaj   +1 more source

The plasma metabolite-mediated relationship between inflammatory cytokines and acute respiratory distress syndrome

Archives of Medical Science
Introduction Biomarkers of acute respiratory distress syndrome (ARDS) can provide precise treatment options. ARDS is a clinical syndrome characterized by diffuse lung inflammation and edema, often leading to acute respiratory failure.
Fan Fu, Zhiying Lin
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source