Results 71 to 80 of about 23,676,347 (287)

mediation: R package for causal mediation analysis [PDF]

, 2012
In this paper, we describe the R package mediation for conducting causal mediation analysis in applied empirical research. In many scientific disciplines, the goal of researchers is not only estimating causal effects of a treatment but also understanding
Keele, Luke, Yamamoto, Teppei, Hirose, Kentaro, Imai, Kosuke, Tingley, Dustin   +4 more
core  

Data_Sheet_1_A Practical Guide to Causal Mediation Analysis: Illustration With a Comprehensive College Transition Program and Nonprogram Peer and Faculty Interactions.docx

, 2022
Experimental and quasi-experimental designs have been increasingly employed in education. Mediation analysis has long been used to measure the role of mediators.
Sijia Huang (631307), Tatiana Melguizo (13196046), W. Edward Chi (13196043), Elizabeth S. Park (11873415), Adrianna Kezar (13196049), Minjeong Jeon (1747555)   +5 more
core   +1 more source

Sequential Transport for Causal Mediation Analysis

CoRR
We propose sequential transport (ST), a distributional framework for mediation analysis that combines optimal transport (OT) with a mediator directed acyclic graph (DAG). Instead of relying on cross-world counterfactual assumptions, ST constructs unit-level mediator counterfactuals by minimally transporting each mediator, either marginally or ...
Agathe Fernandes Machado, Iryna Voitsitska, Arthur Charpentier, Ewen Gallic   +3 more
openaire   +3 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Translating Mediation Guidance into Practice: Commentary on the UN Guidance for Effective Mediation by the Mediation Support Network [PDF]

, 2012
This is a short monograph that summarizes a series of meetings of the Mediation Support Network (MSN), a network of primarily non-governmental organizations (NGOs) that support mediation in peace negotiations.
Dziatkowiec, Paul, Kraus, Anne Isabel, Yousuf, Zahbia, Alvarez, Miguel, Avasiloae, Sabina, Mason, Simon, Unger, Barbara, Mutisi, Martha, Stock, Nathan, Kirchhoff, Lars, Cristescu, Roxana, Hellmueller, Sara   +11 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Conducting Regression-based Causal Mediation Analysis Using the R Package "regmedint"

, 2020
The R package regmedint is a complete implementation of the regression formula-based causal mediation ...
Maya Mathur, Kazuki Yoshida, Robert J. Glynn, Maya B Mathur   +3 more
core   +1 more source

Causal relationships between gut microbiota and urothelial carcinoma mediated by inflammatory cytokines and blood cell traits identified through Mendelian randomization analysis

Discover Oncology
Background The role of gut microbiota in tumorigenesis has gained significant attention in recent years. This study aimed to investigate the causal relationship between gut microbiota and three types of urothelial carcinoma (renal pelvic cancer [RPC ...
Xipeng Wu, Wenda Zou, Ziwei Liu
doaj   +1 more source