Results 71 to 80 of about 64,095 (292)

Sequential Transport for Causal Mediation Analysis

CoRR
We propose sequential transport (ST), a distributional framework for mediation analysis that combines optimal transport (OT) with a mediator directed acyclic graph (DAG). Instead of relying on cross-world counterfactual assumptions, ST constructs unit-level mediator counterfactuals by minimally transporting each mediator, either marginally or ...
Agathe Fernandes Machado, Iryna Voitsitska, Arthur Charpentier, Ewen Gallic   +3 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Causal Mediation Analysis for Effect Heterogeneity

, 2021
It is possible to quantify and understand how an exposure affects an outcome through an intermediate variable via causal mediation analysis. In many cases in practice, however, the effect of the exposure may vary for different subgroups of the population.
Zhang, Jiaqing
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Impact of Telemedicine Adoption on Hemiplegia in Patients With Stroke in Florida: Longitudinal Observational Study

Journal of Medical Internet Research
BackgroundTelemedicine has emerged as a critical tool in the management of acute stroke; yet, its impact on clinical decision-making, particularly in the administration of tissue plasminogen activator (tPA), remains underexplored.
Yao Li, Mingshan Zhang, Weiling Ke, Wenwen Li   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Causal relationships between gut microbiota and urothelial carcinoma mediated by inflammatory cytokines and blood cell traits identified through Mendelian randomization analysis

Discover Oncology
Background The role of gut microbiota in tumorigenesis has gained significant attention in recent years. This study aimed to investigate the causal relationship between gut microbiota and three types of urothelial carcinoma (renal pelvic cancer [RPC ...
Xipeng Wu, Wenda Zou, Ziwei Liu
doaj   +1 more source

Dissecting the causal relationship between insomnia, plasma metabolites, and anxiety: A mediated mendelian randomization study

Journal of Affective Disorders Reports
Objective: This study employed a two-sample Mendelian randomization (MR) approach to investigate the causal relationships among insomnia, plasma metabolites, and anxiety disorders.
Qi Fan, Jiaxin Li, Yushi Tian, Qingyuan Meng, Mingyue Lan, Xiaoyang Hu   +5 more
doaj   +1 more source

Counterfactual graphical models for longitudinal mediation analysis with unobserved confounding

, 2013
Questions concerning mediated causal effects are of great interest in psychology, cognitive science, medicine, social science, public health, and many other disciplines.
Shpitser, Ilya
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source