Results 51 to 60 of about 64,095 (292)
Causal Mediation Analysis With Survival Data [PDF]
Epidemiology, 2011 Causal mediation analysis is considered for time-to-event outcomes and survival analysis models. Different possible effect decompositions are discussed for the survival function, hazard, mean survival time and median survival scales. Approaches to mediation analysis in the social sciences are related to counterfactual approaches using additive hazard ...
openaire +2 more sources
Causal mediation analysis in presence of multiple mediators uncausally related [PDF]
The International Journal of Biostatistics, 2020 Abstract Mediation analysis aims at disentangling the effects of a treatment on an outcome through alternative causal mechanisms and has become a popular practice in biomedical and social science applications. The causal framework based on counterfactuals is currently the standard approach to mediation, with important methodological ...
Jérolon, Allan +4 more
openaire +6 more sources
mediation: R package for causal mediation analysis [PDF]
, 2012 In this paper, we describe the R package mediation for conducting causal mediation analysis in applied empirical research. In many scientific disciplines, the goal of researchers is not only estimating causal effects of a treatment but also understanding
Keele, Luke +4 more
core
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono +7 more
wiley +1 more source
The Causal Mechanism of Financial Education: Evidence from Mediation Analysis [PDF]
, 2020 This paper uses a field experiment in India and mediation analysis to investigate the causal mechanisms between financial education and financial behavior.
Carpena, Fenella, Zia, Bilal
core +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Investigating causal mechanisms in randomised controlled trials
Trials, 2019 Introduction In some randomised trials, the primary interest is in the mechanisms by which an intervention exerts its effects on health outcomes. That is, clinicians and policy-makers may be interested in how the intervention works (or why it does not ...
Hopin Lee +4 more
doaj +1 more source
Bayesian causal mediation analysis with multiple ordered mediators
Statistical Modelling, 2018 Causal mediation analysis provides investigators insight into how a treatment or exposure can affect an outcome of interest through one or more mediators on causal pathway. When multiple mediators on the pathway are causally ordered, identification of mediation effects on certain causal pathways requires a sensitivity parameter to be specified. A mixed
Gao, Tianming, Albert, Jeffrey M.
openaire +3 more sources
Causal mediation analysis in the context of clinical research [PDF]
Annals of Translational Medicine, 2016 Clinical researches usually collected numerous intermediate variables besides treatment and outcome. These variables are often incorrectly treated as confounding factors and are thus controlled using a variety of multivariable regression models depending on the types of outcome variable.
Zhongheng, Zhang +5 more
openaire +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source