Results 141 to 150 of about 64,095 (292)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Role of plasma metabolome in mediating the effect of plasma lipidome on NAFLD: a Mendelian randomization study

Frontiers in Endocrinology
BackgroundThis study explored the causal connection among the plasma lipidome, nonalcoholic fatty liver disease (NAFLD), and potential metabolome mediators through Mendelian randomization (MR).MethodsWe obtained summary statistics for 179 plasma lipidome
Zhuyuan Zheng, Shaojie Yang, Wanlin Dai, Yang Sun, Jingnan Wang, Xiaolin Zhang, Yiming Zheng, Jing Kong   +7 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Semiparametric Causal Mediation Analysis with Unmeasured Mediator-Outcome Confounding

Statistica Sinica
Although the exposure can be randomly assigned in studies of mediation effects, any form of direct intervention on the mediator is often infeasible. As a result, unmeasured mediator-outcome confounding can seldom be ruled out. We propose semiparametric identification of natural direct and indirect effects in the presence of unmeasured mediator-outcome ...
Sun, Baoluo, Ye, Ting
openaire   +3 more sources

A Class of Distribution-free Models for Longitudinal Mediation Analysis

, 2012
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Biostatistics and Computational Biology, 2011.My thesis research focuses on developing novel statistical models and applications to address important methodological ...
Gunzler, Doug, Tu, Xin M.
core  

The causal effects of placental weight on atherosclerotic cardiovascular disease: a Mendelian randomization and mediation analysis

Introduction Previous studies have linked placental weight (PW) to cardiovascular diseases, but the causality and potential mediators underlying this relationship are still unknown. Material and methods We conducted Mendelian randomization (MR) analysis
Shilin Fan, Chong Hou, Min Peng, Jiaxuan Sun, Songtao Shou, Dongyue Chen, Ke Yang, Quanyan Liu   +7 more
core   +1 more source

Generalized causal mediation and path analysis: Extensions and practical considerations

, 2018
Causal mediation analysis seeks to decompose the effect of a treatment or exposure among multiple possible paths and provide casually interpretable path-specific effect estimates.
Jang Ik Cho, Suchitra Nelson, Yiying Liu, Jeffrey M Albert   +3 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Similar Survival Between Non-Western Immigrant Patients and Danish-Born Patients with Lymphoma: A Danish Population-Based Study

Clinical Epidemiology
Mikkel Runason Simonsen,1,2 Eva Futtrup Maksten,1,3 Lasse Hjort Jakobsen,1 Marianne Tang Severinsen,1,3 Eldad J Dann,4 Henrik Frederiksen,5,6 Carsten Utoft Niemann,7 Judit Mészáros Jørgensen,8 Michael Roost Clausen,9 Jørn Starklint,10 Søren Paaske ...
Simonsen MR, Maksten EF, Jakobsen LH, Severinsen MT, Dann EJ, Frederiksen H, Niemann CU, Jørgensen JM, Clausen MR, Starklint J, Johnsen SP, El-Galaly TC, Baech J   +12 more
doaj  

Plasma metabolome mediates the causal relationship between immune cells and heart failure: a two-step bidirectional Mendelian randomization study

Frontiers in Cardiovascular Medicine
BackgroundPrior research has established a correlation between immune cell activity and heart failure (HF), but the causal nature of this relationship remains unclear.
Tan Li, Yanwei Liu, Juncong Fu, Langlang Huang, Langlang Huang, Zhongyong Liu   +5 more
doaj   +1 more source