Results 81 to 90 of about 10,493,362 (203)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Three Sensitivity-Analysis Methods to Assess Unmeasured Pretreatment Confounding Bias in Experimental Mediation Analysis

Advances in Methods and Practices in Psychological Science
Statistical-mediation analysis is a widely used method in psychological research that helps understand the intermediate variables, known as mediators ( M ), by which an independent variable ( X ) causes an outcome variable ( Y ).
Diana Alvarez-Bartolo, David P. MacKinnon   +1 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A Novel Causal Mediation Analysis Approach for Zero-Inflated Mediators

, 2023
Mediation analyses play important roles in making causal inference in biomedical research to examine causal pathways that may be mediated by one or more intermediate variables (i.e., mediators).
Li, Zhigang, Lee, Seonjoo, Stern, Yaakov, Jiang, Meilin, O'Malley, James   +4 more
core  

Causal Mediation Analysis With Treatment Noncompliance

When evaluating a new intervention, we often seek causality, which we may estimate by the intervention's average treatment effect. When interest is in the causal mechanism, causal mediation analysis is more appropriate.
Lind, Miriam
core   +2 more sources

Causal relationships between gut microbiota, immune cell, and Henoch-Schönlein Purpura: a two-step, two-sample Mendelian randomization study

Frontiers in Immunology
BackgroundRegulating the immune system is a crucial measure of gut microbiota (GM) that influences the development of diseases. The causal role of GM on Henoch-Schönlein Purpura (HSP) and whether it can be mediated by immune cells is still unknown ...
Tian Liang, Huijun Shi, Han Cui, Yaqi Cui, Ziwei Zhao, Yue Wang, Dandan Shi, Peichao Tian   +7 more
doaj   +1 more source

Interventional Approach for Path-Specific Effects

Journal of Causal Inference, 2017
Standard causal mediation analysis decomposes the total effect into a direct effect and an indirect effect in settings with only one single mediator.
Lin Sheng-Hsuan, VanderWeele Tyler
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Genetic insights into the interaction between chronic hepatitis B virus infection and metabolic syndrome

Virulence
The association between chronic hepatitis B virus (HBV) infection and metabolic syndrome (MetS) remains controversial. We aimed to analyze the causal effects of chronic HBV infection on MetS components and vice versa.
Juanjuan Zou, Yijing Zhang, Xiaojing Sun, Yan Wang, Yanzhong Li, Ze-Hua Zhao   +5 more
doaj   +1 more source