Results 101 to 110 of about 10,493,362 (203)

Estimating the Bayesian posterior distribution of indirect effects in causal longitudinal mediation analysis

Many research studies aim to unveil the causal mechanism underlying a particular phenomenon; mediation analysis is increasingly used for this scope, and longitudinal data are particularly suited for mediation since they ensure the correct temporal order ...
Abbruzzo, Antonino, Di Maria, Chiara, Lovison, Gianfranco   +2 more
core  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The Role of Gut Microbiota on Idiopathic Pulmonary Fibrosis Mediated by Circulating Inflammatory Proteins: A Two‐Step, Two‐Sample Mendelian Randomization Study

The Clinical Respiratory Journal
Background Persistent inflammation is a crucial characteristic of idiopathic pulmonary fibrosis (IPF). Gut microbiota (GM) contribute to the occurrence and development of several pulmonary diseases through the “gut–lung axis.” The genetic role of GM in ...
Hongyu Zhu, Caihua Chen, Haixie Guo, Bo Zhang, Quanteng Hu   +4 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Causal mediation analysis with multiple causally-ordered mediators [PDF]

, 2013
Symposium on Causal Mediation Analysis, Ghent 28–29 January ...
David, Leon, Rhian, Daniel, Bianca, De Stavola   +2 more
core   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Causal mediation analysis using R

, 2009
Causal mediation analysis is widely used across many disciplines to investigate possible causal mechanisms. Such an analysis allows researchers to explore various causal pathways, going beyond the estimation of simple causal effects.
Dustin Tingley, Kosuke Imai, Luke Keele
core  

mediation: R package for causal mediation analysis [PDF]

, 2012
In this paper, we describe the R package mediation for conducting causal mediation analysis in applied empirical research. In many scientific disciplines, the goal of researchers is not only estimating causal effects of a treatment but also understanding
Keele, Luke, Yamamoto, Teppei, Hirose, Kentaro, Imai, Kosuke, Tingley, Dustin   +4 more
core  

Circulating citrate as a mediator in the relationship between HMGCR inhibitors and chronic hepatitis B: a Mendelian randomization study

Scientific Reports
Observational studies have found that HMGCR inhibitors can be used to treat chronic viral hepatitis. In this study, to explore the potential mechanism of HMGCR inhibitors in treating Chronic hepatitis B (CHB), two-sample and two-step Mendelian ...
Lili Zhang, Yuming Li, Ying Li
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source