Lipid compartments and lipid metabolism as therapeutic targets against coronavirus
Frontiers in Immunology, 2023 Lipids perform a series of cellular functions, establishing cell and organelles’ boundaries, organizing signaling platforms, and creating compartments where specific reactions occur.
Daniella Cesar-Silva +5 more
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Small and large intestine express a truncated Dab1 isoform that assembles in cell-cell junctions and co-localizes with proteins involved in endocytosis [PDF]
, 2018 Disabled-1 (Dab1) is an essential intracellular adaptor protein in the reelin pathway. Our previous studies in mice intestine showed that Dab1 transmits the reelin signal to cytosolic signalling pathways.
Balda, María S. +5 more
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The lipoatrophic caveolin-1 deficient mouse model reveals autophagy in mature adipocytes [PDF]
, 2010 Adipose tissue lipoatrophy caused by caveolin gene deletion in mice is not linked to defective adipocyte differentiation. We show that adipose tissue development cannot be rescued by endothelial specific caveolin-1 re-expression, indicating primordial ...
C. Prado +8 more
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Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis [PDF]
, 2021 Huawei Wang +4 more
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Mechanism of caveolin filament assembly [PDF]
Proceedings of the National Academy of Sciences, 2002 Caveolin-1 was the first protein identified that colocalizes with the ≈10-nm filaments found on the inside surface of caveolae membranes. We have used a combination of electron microscopy (EM), circular dichroism, and analytical ultracentrifugation to determine the structure of the oligomers that form when the first 101 aa of caveolin-1 ...
Imma, Fernandez +3 more
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Loss of Caveolin-1 Impairs Light Flicker-Induced Neurovascular Coupling at the Optic Nerve Head
Frontiers in Neuroscience, 2021 Glaucoma is a neurodegenerative disease, which results in characteristic visual field defects. Intraocular pressure (IOP) remains the main risk factor for this leading cause of blindness. Recent studies suggest that disturbances in neurovascular coupling
Jing Hong Loo +13 more
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The use of time-resolved fluorescence imaging in the study of protein kinase C localisation in cells [PDF]
, 2005 Background: Two-photon-excitation fluorescence lifetime imaging (2P-FLIM) was used to investigate the association of protein kinase C alpha (PKCα) with caveolin in CHO cells. PKCα is found widely in the cytoplasm and nucleus in most cells.
Botchway, SW +3 more
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Caveolin-1, caveolae, and glioblastoma [PDF]
Neuro-Oncology, 2012 Glioblastoma multiforme (GBM) is the most common malignant brain tumor and is characterized by high invasiveness, poor prognosis, and limited therapeutic options. Biochemical and morphological experiments have shown the presence of caveolae in glioblastoma cells. Caveolae are flask-shaped plasma membrane subdomains that play trafficking, mechanosensing,
Parat, Marie-Odile, Riggins, Gregory J.
openaire +3 more sources
Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell
Pharmaceutics, 2020 Nanoparticles (NPs) and submicron particles are increasingly used as carriers for delivering therapeutic compounds to cells. Their entry into the cell represents the initial step in this delivery process, being most of the nanoparticles taken up by ...
Darío Manzanares, Valentín Ceña
doaj +1 more source
Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond
Frontiers in Immunology, 2017 Caveolins, encoded by the CAV gene family, are the main protein components of caveolae. In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with Cav-1 ...
Cecília Jacques Gonçalves de Almeida
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