Results 41 to 50 of about 3,741 (219)

Signaling epicenters: the role of caveolae and caveolins in volatile anesthetic induced cardiac protection. [PDF]

, 2014
Caveolae are flask-like invaginations of the cell surface that have been identified as signaling epicenters. Within these microdomains, caveolins are structural proteins of caveolae, which are able to interact with numerous signaling molecules affecting ...
Roth, David M, Horikawa, Yousuke T, Tsutsumi, Yasuo M, Patel, Hemal H   +3 more
core   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Caveolin-1, caveolin-3 and VEGF expression in the masticatory muscles of mdx mice

Folia Histochemica et Cytobiologica, 2011
Duchenne muscular dystrophy (DMD) and murine X-linked muscular dystrophy (mdx), its murine model, are characterized by muscle damage and muscle weakness associated with inflammation and new vessel formation. Caveolins, dystrophin-associated proteins, are
Alexander Spassov, Tomasz Gedrange, Katarzyna Sporniak-Tutak, Agnieszka Mielczarek, Sven Morgenstern, Silke Lucke, Tomasz Gredes, Christiane Kunert-Keil   +7 more
doaj   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

Structure-function analysis of human stomatin: A mutation study. [PDF]

PLoS ONE, 2017
Stomatin is an ancient, widely expressed, oligomeric, monotopic membrane protein that is associated with cholesterol-rich membranes/lipid rafts. It is part of the SPFH superfamily including stomatin-like proteins, prohibitins, flotillin/reggie proteins ...
Stefanie Rungaldier, Ellen Umlauf, Mario Mairhofer, Ulrich Salzer, Christoph Thiele, Rainer Prohaska   +5 more
doaj   +1 more source

Caveolae and caveolins

, 1996
In the past year, we have witnessed considerable progress towards an understanding of the workings of caveolae. Highlights include the identification of new caveolin family members, the characterization of VIP21-caveolin as a cholesterol-binding ...
Robert G Parton, Parton, RG
core   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Сell aspects of chronic noninfectious diseases pathogenesis

Атеросклероз, 2014
Caveolae are plasma membrane invaginations of the majority of differentiated cells. They are especially abundant in endothelial cells, adipocytes, muscle cells, and fibroblasts.
Yu P. Nikitin, E. N. Vorobyova, G. I. Simonova, R. I. Vorobyov, A. S. Kazyzaeva   +4 more
doaj  

Oligomerization of Clostridium perfringens epsilon toxin is dependent upon caveolins 1 and 2. [PDF]

PLoS ONE, 2012
Evidence from multiple studies suggests that Clostridium perfringens ε-toxin is a pore-forming toxin, assembling into oligomeric complexes in the plasma membrane of sensitive cells. In a previous study, we used gene-trap mutagenesis to identify mammalian
Christine M Fennessey, Jinsong Sheng, Donald H Rubin, Mark S McClain   +3 more
doaj   +1 more source