Results 41 to 50 of about 6,074 (242)

Energy and Dynamics of Caveolae Trafficking

Frontiers in Cell and Developmental Biology, 2021
Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane domain is characterized and formed by specific lipid binding proteins including ...
Claudia Matthaeus, Justin W. Taraska
doaj   +1 more source

Mutational analysis of caveolin‐induced vesicle formation [PDF]

FEBS Letters, 1998
Caveolae are vesicular organelles with a characteristic uniform diameter in the range of 50–100 nm. Although recombinant expression of caveolin‐1 is sufficient to drive caveolae formation, it remains unknown what controls the uniform diameter of these organelles.
Li, Shengwen, Galbiati, Ferruccio, Volonte', Daniela, Sargiacomo, Massimo, Engelman, Jeffrey A, Das, Kallol, Scherer, Philipp E, Lisanti, Michael P   +7 more
openaire   +2 more sources

Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders. [PDF]

, 2009
Here we review the clinical and translational implications of the caveolin gene family for understanding the pathogenesis of human diseases, including breast and prostate cancers, pulmonary hypertension, cardiomyopathy, diabetes, and muscular dystrophy ...
Flomenberg, Neal, Frank, Philippe G, Jasmin, Jean-Francois, Lisanti, Michael P, Mercier, Isabelle, Minetti, Carlo, Pavlides, Stephanos, Pestell, Richard G, Sotgia, Federica   +8 more
core   +3 more sources

Caveolin as a Potential Drug Target for Cardiovascular Protection

Frontiers in Physiology, 2012
Caveolae and caveolin are key players in a number of disease processes. Current research indicates that caveolins play a significant role in cardiovascular disease and dysfunction.
Stephanie L Sellers, Andy eTrane, Pascal N Bernatchez   +2 more
doaj   +1 more source

Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress. [PDF]

, 2017
Sirtuin1 (Sirt1) is a class III histone deacetylase that regulates a variety of physiological processes, including endothelial function. Caveolin1 (Cav1) is also an important determinant of endothelial function. We asked if Sirt1 governs endothelial Cav1
Gabani, Mohanad, Irani, Kaikobad, Jacobs, Julia S, Kassan, Adam, Kassan, Modar, Kim, Young-Rae, Kumar, Santosh, Li, Qiuxia, Liu, Jing, Patel, Hemal H, Vikram, Ajit   +10 more
core   +7 more sources

Integration of genetics into a systems model of electrocardiographic traits using humanCVD BeadChip [PDF]

, 2012
<p>Background—Electrocardiographic traits are important, substantially heritable determinants of risk of arrhythmias and sudden cardiac death.</p> <p>Methods and Results—In this study, 3 population-based cohorts (n=10 526) genotyped ...
Adeniran, I., Amuzu, A., Braund, P.S., Burton, P.R., Casas, J.-P., Day, I.N.M., Drenos, F., Eriksson, P., Folkersen, L., Gaunt, T.R., Hancox, J.C., Hingorani, A.D., Humphries, S.E., Kivimaki, M., Kumari, M., Lawlor, D.A., Macfarlane, P.W., Nelson, C.P., Samani, N.J., Shah, S., Talmud, P.J., Tobin, M.D., Tomaszewski, M., Whittaker, J., Zhang, H.   +24 more
core   +1 more source

Caveolins: Targeting Pro-survival Signaling in the Heart and Brain

Frontiers in Physiology, 2012
The present review discusses intracellular signaling moieties specific to membrane lipid rafts (MLRs) and the scaffolding proteins caveolin and introduces current data promoting their potential role in the treatment of pathologies of the heart and brain.
Creed M. Stary, Yasuo M. Tsutsumi, Piyush M. Patel, Brian P. Head, Hemal H. Patel, David M. Roth   +5 more
doaj   +1 more source

Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis [PDF]

, 2015
Peritoneal dialysis (PD) is a form of renal replacement therapy whose repeated use can alter dialytic function through induction of epithelial-mesenchymal transition (EMT) and fibrosis, eventually leading to PD discontinuation. The peritoneum from Cav1-/-
Enrique, Calvo, Ignacio, Benedicto, Jesús, Loureiro, Jesús, Vázquez, Manuel López, Cabrera, Maria Teresa, Osteso, María Luisa Pérez, Lozano, Miguel Angel del, Pozo, Miguel, Foronda, Olga, Barreiro, Strippoli, Raffaele, Susana, Minguet, Teijo, Pellinen, Vanessa, Moreno   +13 more
core   +1 more source

Myocardin Family Members Drive Formation of Caveolae.

PLoS ONE, 2015
Caveolae are membrane organelles that play roles in glucose and lipid metabolism and in vascular function. Formation of caveolae requires caveolins and cavins.
Katarzyna K Krawczyk, Ingrid Yao Mattisson, Mari Ekman, Nikolay Oskolkov, Rebecka Grantinge, Dorota Kotowska, Björn Olde, Ola Hansson, Sebastian Albinsson, Joseph M Miano, Catarina Rippe, Karl Swärd   +11 more
doaj   +1 more source

Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. [PDF]

, 2015
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually ...
Duan, Zhenfeng, Guo, Wei, Hornicek, Francis J, Mankin, Henry J, Shen, Jacson K, Sun, Xin   +5 more
core   +3 more sources