Results 61 to 70 of about 6,074 (242)
Oligomerization of Clostridium perfringens epsilon toxin is dependent upon caveolins 1 and 2. [PDF]
PLoS ONE, 2012 Evidence from multiple studies suggests that Clostridium perfringens ε-toxin is a pore-forming toxin, assembling into oligomeric complexes in the plasma membrane of sensitive cells. In a previous study, we used gene-trap mutagenesis to identify mammalian
Christine M Fennessey +3 more
doaj +1 more source
Identifying the role of caveolin-1 and caveolin-2 in cancer cell proliferation and cancer drug resistance [abstract] [PDF]
, 2006 only availableFaculty Mentor: Dr. Grzegorz Sowa, Medical Pharmacology and PhysiologyCaveolae are flask-shaped invaginations of the plasma membrane. Caveolins are the major protein component building these caveolae.
Myears, Hillary E.
core
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Caveolae and caveolins role in health and disease
Кардиоваскулярная терапия и профилактика, 2008 Discovered more than 50 years ago, caveolae for a long time have remained enigmatic plasmalemmal organelles. They were described as 50-100-nm invaginations of the plasma membrane observed using electron microscopy.
R. I. Voroblev +4 more
doaj
Caveolin-1, caveolin-3 and VEGF expression in the masticatory muscles of mdx mice
Folia Histochemica et Cytobiologica, 2011 Duchenne muscular dystrophy (DMD) and murine X-linked muscular dystrophy (mdx), its murine model, are characterized by muscle damage and muscle weakness associated with inflammation and new vessel formation. Caveolins, dystrophin-associated proteins, are
Alexander Spassov +7 more
doaj +1 more source
Advanced Science, EarlyView.Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li +9 more
wiley +1 more source
Mechanism of caveolin filament assembly [PDF]
Proceedings of the National Academy of Sciences, 2002 Caveolin-1 was the first protein identified that colocalizes with the ≈10-nm filaments found on the inside surface of caveolae membranes. We have used a combination of electron microscopy (EM), circular dichroism, and analytical ultracentrifugation to determine the structure of the oligomers that form when the first 101 aa of caveolin-1 ...
Imma, Fernandez +3 more
openaire +2 more sources
Сell aspects of chronic noninfectious diseases pathogenesis
Атеросклероз, 2014 Caveolae are plasma membrane invaginations of the majority of differentiated cells. They are especially abundant in endothelial cells, adipocytes, muscle cells, and fibroblasts.
Yu P. Nikitin +4 more
doaj
Cell Death Discovery, 2022 More than half of HNSCC patients are diagnosed with advanced disease. Locally advanced HNSCC is characterized by tumors with marked local invasion and evidence of metastasis to regional lymph nodes.
Yafei Wang +10 more
doaj +1 more source
Caveolae in Rabbit Ventricular Myocytes: Distribution and Dynamic Diminution after Cell Isolation [PDF]
, 2017 Caveolae are signal transduction centers, yet their subcellular distribution and preservation in cardiac myocytes after cell isolation are not well documented.
Alexander D. Corbett +97 more
core +2 more sources