Results 41 to 50 of about 27,120 (180)
RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of α2 GABAA receptors. [PDF]
PLoS Genetics, 2017 In developing brain neuronal migration, dendrite outgrowth and dendritic spine outgrowth are controlled by Cdc42, a small GTPase of the Rho family, and its activators.
Claire de Groot +10 more
doaj +1 more source
Movement Disorders, EarlyView.Abstract Background Serotonergic and dopaminergic pathways are implicated in Parkinson's disease psychosis (PDP), but preliminary evidence also implicates the endocannabinoid system (ECS). Objectives We examined the association of gray matter volume loss in PDP patients with brain expression of the genes coding for CB1 (cannabinoid type 1) and CB2 ...
Sara Pisani +3 more
wiley +1 more source
Recent trends in studying of alcohol-induced liver disease
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2011 The aim of review. To analyze main epidemiologic tendencies of development of alcoholic liver disease, mechanisms of its development, mortality in this population of patients.
I. I. Komkova +2 more
doaj
Phytotherapy Research, EarlyView.Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli +4 more
wiley +1 more source
Cannabinoid 1 Receptor Signaling on Hippocampal GABAergic Neurons Influences Microglial Activity
Frontiers in Molecular Neuroscience, 2018 Microglia, the resident immune cells of the brain, play important roles in defending the brain against pathogens and supporting neuronal circuit plasticity.
Frank Ativie +8 more
doaj +1 more source
Veterinary Record, EarlyView.Abstract Background Data evaluating paracetamol combined with NSAIDs in dogs are scarce. Results of clinical studies in dogs investigating intravenous paracetamol vary. Methods Dogs were randomised to either receive 10 mg/kg paracetamol intravenously after induction of anaesthesia and every 8 hours during hospitalisation (test) or not (control).
Robin Stallard +2 more
wiley +1 more source
Addiction, EarlyView.Abstract Background and aims Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working‐memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear ...
Yi‐Hsuan Liu +8 more
wiley +1 more source
Addiction, EarlyView.Abstract Background and aims Epidemiologic research suggests that adolescent cannabis use is associated with psychological distress (i.e. depression and anxiety symptoms); however, most studies have relied on 20th‐century data, when cannabis was significantly less potent than today.
André J. McDonald +12 more
wiley +1 more source
Structural basis for activation of CB1 by an endocannabinoid analog
Nature Communications, 2023 Endocannabinoids (eCBs) are endogenous ligands of the cannabinoid receptor 1 (CB1), a G protein-coupled receptor that regulates a number of therapeutically relevant physiological responses.
Kaavya Krishna Kumar +12 more
doaj +1 more source
Addiction, EarlyView.Abstract Background and aims Cannabis is the most widely used illicit drug worldwide and is often co‐used with tobacco, the leading cause of preventable death. Although cannabis and tobacco have distinct neurobiological actions, their associations with brain volumes are unclear.
Katherine Sawyer +16 more
wiley +1 more source