Results 21 to 30 of about 97,974 (286)
Molecular determinants for CC-chemokine recognition by a poxvirus CC-chemokine inhibitor [PDF]
Proceedings of the National Academy of Sciences, 2001 Poxviruses express a family of secreted proteins that bind with high affinity to chemokines and antagonize the interaction with their cognate G protein-coupled receptors (GPCRs). These viral inhibitors are novel in structure and, unlike cellular chemokine receptors, are able to specifically interact with most, if not all, CC-chemokines.
B T, Seet +5 more
openaire +2 more sources
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands. [PDF]
Int J Mol Sci, 2020 CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC domain that play an important role in immune system cells, such as CD4+ and CD8+ lymphocytes, dendritic cells, eosinophils, macrophages, monocytes, and NK cells, as ...
Korbecki J +4 more
europepmc +2 more sources
The CC Chemokine Eotaxin (CCL11) Is a Partial Agonist of CC Chemokine Receptor 2b [PDF]
Journal of Biological Chemistry, 2001 Despite sharing considerable homology with the members of the monocyte chemoattractant protein (MCP) family, the CC chemokine eotaxin (CCL11) has previously been reported to signal exclusively via the receptor CC chemokine receptor 3 (CCR3). Using the monocyte cell line THP-1, we investigated the relative abilities of eotaxin and MCPs 1-4 to induce ...
R, Martinelli +4 more
openaire +2 more sources
Cancer Cell International, 2021 Background The tumor microenvironment (TME) has received an increasing amount of attention. CXC chemokines can regulate immune cell transport and tumor cell activity to exert anti-tumor immunity.
Weina Kong +7 more
doaj +1 more source
iScience, 2022 Summary: Inflammatory cytokines and chemokines (CC) drive COVID-19 pathology. Yet, patients with similar circulating CC levels present with different disease severity. Here, we determined 171 microRNAomes from 58 hospitalized COVID-19 patients (Cohort 1)
Julie C. Wilson +20 more
doaj +1 more source
Nature Communications, 2023 CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but chemokine network redundancy thwarts pharmacological intervention. Tick evasins promiscuously bind CC and CXC-chemokines, overcoming redundancy.
Serena Vales +13 more
doaj +1 more source
Biomedicines, 2023 Cervical cancer (CC) is a serious global health issue, and it is well-known that HPV infection is the main etiological factor that triggers carcinogenesis.
Leonardo Fernandez-Avila +5 more
doaj +1 more source
Differential expression of CC chemokines (CCLs) and receptors (CCRs) by human T lymphocytes in response to different Aggregatibacter actinomycetemcomitans serotypes. [PDF]
J Appl Oral Sci, 2015 In Aggregatibacter actinomycetemcomitans, different serotypes have been described based on LPS antigenicity. Recently, our research group has reported a differential immunogenicity when T lymphocytes were stimulated with these different serotypes.
Alvarez C +6 more
europepmc +4 more sources
Receptor-mediated Endocytosis of CC-chemokines [PDF]
Journal of Biological Chemistry, 1997 Chemokines are chemotactic proteins which play a central role in immune and inflammatory responses. Chemokine receptors are members of the seven transmembrane G-protein coupled family and have recently been shown to be involved in the entry of human immunodeficiency virus (HIV) into target cells.
R, Solari +7 more
openaire +2 more sources
Solution Structure of the Human CC Chemokine 2: A Monomeric Representative of the CC Chemokine Subtype, [PDF]
Biochemistry, 1999 HCC-2, a 66-amino acid residue human CC chemokine, was reported to induce chemotaxis on monocytes, T-lymphocytes, and eosinophils. The three-dimensional structure of HCC-2 has been determined by 1H nuclear magnetic resonance (NMR) spectroscopy and restrained molecular dynamics calculations on the basis of 871 experimental restraints.
H, Sticht +5 more
openaire +2 more sources