Results 21 to 30 of about 157,673 (251)
Nature Communications, 2023 CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but chemokine network redundancy thwarts pharmacological intervention. Tick evasins promiscuously bind CC and CXC-chemokines, overcoming redundancy.
Serena Vales +13 more
doaj +1 more source
Biomedicines, 2023 Cervical cancer (CC) is a serious global health issue, and it is well-known that HPV infection is the main etiological factor that triggers carcinogenesis.
Leonardo Fernandez-Avila +5 more
doaj +1 more source
Receptor-mediated Endocytosis of CC-chemokines [PDF]
Journal of Biological Chemistry, 1997 Chemokines are chemotactic proteins which play a central role in immune and inflammatory responses. Chemokine receptors are members of the seven transmembrane G-protein coupled family and have recently been shown to be involved in the entry of human immunodeficiency virus (HIV) into target cells.
R, Solari +7 more
openaire +2 more sources
Solution Structure of the Human CC Chemokine 2: A Monomeric Representative of the CC Chemokine Subtype, [PDF]
Biochemistry, 1999 HCC-2, a 66-amino acid residue human CC chemokine, was reported to induce chemotaxis on monocytes, T-lymphocytes, and eosinophils. The three-dimensional structure of HCC-2 has been determined by 1H nuclear magnetic resonance (NMR) spectroscopy and restrained molecular dynamics calculations on the basis of 871 experimental restraints.
H, Sticht +5 more
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HIV protective KIR3DL1/S1-HLA-B genotypes influence NK cell-mediated inhibition of HIV replication in autologous CD4 targets. [PDF]
PLoS Pathogens, 2014 Carriage of the genetic combination encoding a high expression inhibitory Killer Immunoglobulin-like Receptor (KIR)3DL1 with its ligand, HLA-B*57 (*h/*y+B*57) is associated with slower time to AIDS and better HIV viral load control than being a Bw6 ...
Rujun Song +5 more
doaj +1 more source
Chemokine-induced phosphorylation of CC chemokine receptor 5 (CCR5) [PDF]
Journal of Leukocyte Biology, 1999 Abstract The CC-chemokine receptor 5 (CCR5) mediates activation of T lymphocytes and macrophages by chemokines and is a major co-receptor for macrophage-tropic HIV-1 strains. Recently, it was shown that the natural CCR5 ligands RANTES, macrophage inflammatory protein-1á (MIP-1á), MIP-1β, and amino-terminal modifications of RANTES (Met ...
H, Olbrich, A E, Proudfoot, M, Oppermann
openaire +2 more sources
The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3 [PDF]
Proceedings of the National Academy of Sciences, 1998 We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X. We screened a large panel of chemokines for their ability to induce a calcium flux in mouse CXCR3-transfected cells and identified a new ligand for this receptor, the recently reported CC chemokine 6Ckine.
H, Soto +7 more
openaire +2 more sources
Frontiers in Microbiology, 2019 Parapoxvirus of red deer in New Zealand (PVNZ) is a species of the Parapoxvirus genus that causes pustular dermatitis. We identified a cluster of genes in PVNZ that encode three unique chemokine-binding proteins (CBPs) namely ORF112.0, ORF112.3 and ...
Saeed Sharif +7 more
doaj +1 more source
CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
Memorias do Instituto Oswaldo Cruz, 2005 The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control.
APMP Marino +6 more
doaj +1 more source
The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis
Frontiers in Immunology, 2022 Herpes stromal keratitis (HSK) is a blinding corneal disease caused by herpes simplex virus-1 (HSV-1), a common pathogen infecting most of the world’s population.
Tian Yu +9 more
doaj +1 more source