Results 41 to 50 of about 97,974 (286)

The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis

Frontiers in Immunology, 2022
Herpes stromal keratitis (HSK) is a blinding corneal disease caused by herpes simplex virus-1 (HSV-1), a common pathogen infecting most of the world’s population.
Tian Yu, Tian Yu, Fabian Schuette, Maria Christofi, John V. Forrester, John V. Forrester, John V. Forrester, Gerard J. Graham, Lucia Kuffova, Lucia Kuffova   +9 more
doaj   +1 more source

Enhanced Levels of Chemokines and Their Receptors in the Colon of Microscopic Colitis Patients Indicate Mixed Immune Cell Recruitment

Mediators of Inflammation, 2015
Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhea. Various immune cell infiltrations in the epithelium and lamina propria are seen in MC immunopathology. We compared gene and
Sezin Günaltay, Ashok Kumar Kumawat, Nils Nyhlin, Johan Bohr, Curt Tysk, Olof Hultgren, Elisabeth Hultgren Hörnquist   +6 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A comparative investigation of CC chemokines and SIV suppressor factors generated by CD8(+) and CD4(+) T cells and CD14(+) monocytes

, 2002
The capacity of CD8(+) and CD4(+) T cells and CD14(+) monocytes to generate the CC chemokines, RANTES, MIP-1alpha. and MIP-1beta, and SIV suppressor factors were studied using cells separated from PBMC of macaques immunized with the 70-kDa heat shock ...
Singh, M, Whittall, T, Wang, Y F, Bergmeier, L A, Lehner, T, Babaahmady, K   +5 more
core   +1 more source

A comprehensive bioinformatics analysis to identify potential prognostic biomarkers among CC and CXC chemokines in breast cancer

Scientific Reports, 2022
Breast cancer (BC) is a major human health problem due to its increasing incidence and mortality rate. CC and CXC chemokines are associated with tumorigenesis and the progression of many cancers.
Hossein Hozhabri, Marziyeh Mazaheri Moghaddam, Madiheh Mazaheri Moghaddam, Ali Mohammadian   +3 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities

Scientific Reports, 2017
Chemokines function via G-protein coupled receptors in a robust network to recruit immune cells to sites of inflammation. Due to the complexity of this network, targeting single chemokines or receptors has not been successful in inflammatory disease. Dog
Kamayani Singh, Graham Davies, Yara Alenazi, James R. O. Eaton, Akane Kawamura, Shoumo Bhattacharya   +5 more
doaj   +1 more source

ANGIOGENIC AND ANGIOSTATIC CHEMOKINES LEVEL IN NORMAL SYNOVIAL FLUID

Медицинская иммунология, 2014
Chemokines are believed to play an important role in immunopathogenesis of different joint diseases. One of important problems in studies of synovial fluid is determination of normal level of chemokines from control patients.
D. A. Zhebrun, A. L. Maslyanskiy, A. G. Titov, A. P. Patruhin, A. A. Kostareva, N. A. Arsentieva, N. E. Lubimova, A. V. Semenov, Areg A. Totolian   +8 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6

, 2003
In an effort to define the actual function of the promiscuous putatively silent chemokine receptor D6, transfectants were generated in different cell types.
SIGNORELLI P, K. Otero, GOBBI M, SOZZANI, Silvano, SIRONI M, VECCHI A, MASSARDI, Maria Luisa, M. Gobbi, MANTOVANI A., A. M. Fra, A. Mantovani, LOCATI M, M. L. Massardi, M. Locati, FRA, Annamaria, S. Sozzani, P. Signorelli, OTERO K, M. Sironi, A. Vecchi   +19 more
core   +1 more source