Results 61 to 70 of about 129,465 (297)

Human metapneumovirus: Mechanisms and molecular targets used by the virus to avoid the immune system [PDF]

, 2018
Indexación: Scopus.This work was supported by Comisión Nacional de Investigación Científica y Tecnolígica (CONICYT) N◦21151028 and FONDECYT (N◦1070352 and N◦1170964) and the Millennium Institute on Immunology and Immunotherapy (P09/016-F).Human ...
Benavente, F.M., Bueno, S.M., Gonzalez, P.A., Gálvez, N.M.S., Kalergis, A.M., Lay, M.K., Pizarro-Ortega, M.S., Riedel, C., Soto, J.A.   +8 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

The CC Chemokine Eotaxin (CCL11) Is a Partial Agonist of CC Chemokine Receptor 2b [PDF]

Journal of Biological Chemistry, 2001
Despite sharing considerable homology with the members of the monocyte chemoattractant protein (MCP) family, the CC chemokine eotaxin (CCL11) has previously been reported to signal exclusively via the receptor CC chemokine receptor 3 (CCR3). Using the monocyte cell line THP-1, we investigated the relative abilities of eotaxin and MCPs 1-4 to induce ...
R, Martinelli, I, Sabroe, G, LaRosa, T J, Williams, J E, Pease   +4 more
openaire   +2 more sources

CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca2+ channels upstream of p38 MAPK. [PDF]

, 2016
BackgroundThe chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system.
Kaul, Marcus, Maung, Ricky, Medders, Kathryn E, Ojeda-Juárez, Daniel, Sanchez, Ana B, Sánchez-Pavón, Paloma   +5 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Structure and function of A41, a vaccinia virus chemokine binding protein.

PLoS Pathogens, 2008
The vaccinia virus (VACV) A41L gene encodes a secreted 30 kDa glycoprotein that is nonessential for virus replication but affects the host response to infection.
Mohammad W Bahar, Julia C Kenyon, Mike M Putz, Nicola G A Abrescia, James E Pease, Emma L Wise, David I Stuart, Geoffrey L Smith, Jonathan M Grimes   +8 more
doaj   +1 more source

The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3 [PDF]

Proceedings of the National Academy of Sciences, 1998
We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X. We screened a large panel of chemokines for their ability to induce a calcium flux in mouse CXCR3-transfected cells and identified a new ligand for this receptor, the recently reported CC chemokine 6Ckine. This represents an example of a CC chemokine,
H, Soto, W, Wang, R M, Strieter, N G, Copeland, D J, Gilbert, N A, Jenkins, J, Hedrick, A, Zlotnik   +7 more
openaire   +2 more sources

Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis? [PDF]

, 2018
Indexación: Scopus.Papillary thyroid cancer (PTC) is the most prevalent endocrine neoplasia. The increased incidence of PTC in patients with thyroiditis and the frequent immune infiltrate found in PTC suggest that inflammation might be a risk factor for ...
Aggarwal, Akaike, Antonelli, Aoki, Balkwill, Balkwill, Balkwill, Ben-Baruch, Ben-Baruch, Ben-Baruch, Bentrem, Bikfalvi, Bressan, Carini, Caux, Cerutti, Chen, Chiovato, Clark, Evers, Fagin, Fallahi, Fallahi, Fallahi, Ferrannini, Fugazzola, Fulton, Giovannone, Harris, Haugen, Huang, Ichikawa, Ishikura, Keane, Keane, Khodarev, Kim, Lai, Lazebnik, Liao, Loetscher, Maggi, Mak, Mantovani, Mantovani, Marazuela, Marone, Matrisian, Matthys, McEvoy, Melillo, Melillo, Melillo, Melillo, Miccoli, Moser, Moser, Nagawa, Negri, Okayasu, Oppenheim, Pal, Pal, Pal, Paloyan, Paloyan, Peled, Peng, Pfaffl, Potlukova, Richmond, Richmond, Rizzoli, Rollins, Romagnani, Rothstein, Santoro, Serio, Serio, Shah, Shaha, Sonoo, Sorensen, Strieter, Strieter, Strieter, Sun, Taketo, Teixido, Toniolo, Tuttle, Vigneri, Ward, Ward, Ward, Welch, Wells, Wells, Wells, Wilhelm, Wu, Wynford-Thomas, Yang, Yeo, Zhang   +104 more
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Genomic organization, annotation, and ligand-receptor inferences of chicken chemokines and chemokine receptor genes based on comparative genomics

BMC Genomics, 2005
Background Chemokines and their receptors play important roles in host defense, organogenesis, hematopoiesis, and neuronal communication. Forty-two chemokines and 19 cognate receptors have been found in the human genome.
Sze Sing-Hoi, Yilmaz Ahmet, Adelson David L, Wang Jixin, Jin Yuan, Zhu James J   +5 more
doaj   +1 more source