The CCCTC-binding factor CTCF represses hepatitis B virus enhancer I and regulates viral transcription. [PDF]
Cell Microbiol, 2021 Hepatitis B virus (HBV) infection is of global importance with over 2 billion people exposed to the virus during their lifetime and at risk of progressive liver disease, cirrhosis and hepatocellular carcinoma. HBV is a member of the Hepadnaviridae family
D'Arienzo V +12 more
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SMURF1 Regulates CTCF-HOXA10 Axis and Promotes Tumor Progression in Nasopharyngeal Carcinoma. [PDF]
Cancer SciOur study showed that SMURF1 was significantly upregulated in nasopharyngeal carcinoma (NPC) and promoted tumor progression and SMURF1 promoted K48‐linked ubiquitination degradation of CTCF. ABSTRACT The aberrant upregulation of Homeobox A10 (HOXA10) has been implicated in the progression of nasopharyngeal carcinoma (NPC), but the mechanisms driving ...
Jin Y +5 more
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The CCCTC-binding factor (CTCF) of Drosophila contributes to the regulation of the ribosomal DNA and nucleolar stability. [PDF]
PLoS ONE, 2011 In the repeat array of ribosomal DNA (rDNA), only about half of the genes are actively transcribed while the others are silenced. In arthropods, transposable elements interrupt a subset of genes, often inactivating transcription of those genes. Little is
Paola A Guerrero, Keith A Maggert
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Molecular Mimics: How Viral Genomes Dupe Their Host by Usurping CTCF to Establish Infection [PDF]
VirusesThe eukaryotic genome is organized into distinct structural units dictated by architectural proteins. The major host architectural protein CCCTC-binding factor (CTCF) is usurped by DNA viruses to regulate viral gene expression.
Clairine I. S. Larsen +2 more
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One protein to rule them all: The role of CCCTC-binding factor in shaping human genome in health and disease [PDF]
Seminars in Cell and Developmental Biology, 2019 Wayne Dawson, Dariusz Plewczynski
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CCCTC-binding factor recruitment to the early region of the human papillomavirus 18 genome regulates viral oncogene expression. [PDF]
J Virol, 2015 C.P. was supported by a Ph.D. studentshipfunded by the University of St. Andrews, School of Medicine. I.P. is supported by a Cancer Research UK (CRUK) Ph.D. studentship awarded to J.L.P. and S.R. I.G. and N.C.
Paris C +7 more
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CCCTC-binding factor is essential to the maintenance and quiescence of hematopoietic stem cells in mice. [PDF]
Exp Mol Med, 2017 Hematopoiesis involves a series of lineage differentiation programs initiated in hematopoietic stem cells (HSCs) found in bone marrow (BM). To ensure lifelong hematopoiesis, various molecular mechanisms are needed to maintain the HSC pool.
Kim TG +6 more
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Key roles of CCCTC-binding factor in cancer evolution and development
Exploration of Medicine, 2021 The processes of cancer and embryonic development have a partially overlapping effect. Several transcription factor families, which are highly conserved in the evolutionary history of biology, play a key role in the development of cancer and are often ...
Zishuai Li +6 more
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CCCTC-Binding Factor Controls Its Own Nuclear Transport via Regulating the Expression of Importin 13 [PDF]
Molecules and Cells, 2013 Wang R, Shen J, Huang P, Zhu X.
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CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs [PDF]
Immunity, 2017 Richard M Myers +2 more
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