CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination [PDF]
Frontiers in Immunology, 2017 In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA.
Ester Marina-Zárate +2 more
doaj +9 more sources
Expression of CCCTC‐binding factor (CTCF) is linked to poor prognosis in prostate cancer [PDF]
Molecular Oncology, 2020 The chromatin‐organizing factor CCCTC‐binding factor (CTCF) is involved in transcriptional regulation, DNA‐loop formation, and telomere maintenance.
Doris Höflmayer +23 more
doaj +5 more sources
The relationship between transcription initiation RNAs and CCCTC-binding factor (CTCF) localization [PDF]
Epigenetics & Chromatin, 2011 Background Transcription initiation RNAs (tiRNAs) are nuclear localized 18 nucleotide RNAs derived from sequences immediately downstream of RNA polymerase II (RNAPII) transcription start sites.
Taft Ryan J +3 more
doaj +8 more sources
The CCCTC-binding factor (CTCF) of Drosophila contributes to the regulation of the ribosomal DNA and nucleolar stability. [PDF]
PLoS ONE, 2011 In the repeat array of ribosomal DNA (rDNA), only about half of the genes are actively transcribed while the others are silenced. In arthropods, transposable elements interrupt a subset of genes, often inactivating transcription of those genes. Little is
Paola A Guerrero, Keith A Maggert
doaj +5 more sources
Genome-wide Studies of CCCTC-binding Factor (CTCF) and Cohesin Provide Insight into Chromatin Structure and Regulation [PDF]
Journal of Biological Chemistry, 2012 Eukaryotic genomes are organized into higher order chromatin architectures by protein-mediated long-range interactions in the nucleus. CCCTC-binding factor (CTCF), a sequence-specific transcription factor, serves as a chromatin organizer in building this complex chromatin structure by linking chromosomal domains.
Bum-Kyu Lee, Vishwanath R Iyer
exaly +5 more sources
Key roles of CCCTC-binding factor in cancer evolution and development [PDF]
Exploration of Medicine, 2021 The processes of cancer and embryonic development have a partially overlapping effect. Several transcription factor families, which are highly conserved in the evolutionary history of biology, play a key role in the development of cancer and are often ...
Zishuai Li +6 more
doaj +2 more sources
Characterization of a new CCCTC-binding factor binding site as a dual regulator of Epstein-Barr virus latent infection. [PDF]
PLoS Pathogens, 2023 Distinct viral gene expression characterizes Epstein-Barr virus (EBV) infection in EBV-producing marmoset B-cell (B95-8) and EBV-associated gastric carcinoma (SNU719) cell lines.
Sun Hee Lee +11 more
doaj +2 more sources
Binding of CCCTC-Binding Factor (CTCF) to the Minute Virus of Mice Genome Is Important for Proper Processing of Viral P4-Generated Pre-mRNAs [PDF]
Viruses, 2020 Specific chromatin immunoprecipitation of salt-fractionated infected cell extracts has demonstrated that the CCCTC-binding factor (CTCF), a highly conserved, 11-zinc-finger DNA-binding protein with known roles in cellular and viral genome organization ...
Maria Boftsi +3 more
doaj +2 more sources
CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection [PDF]
mBio, 2018 Herpes simplex virus 1 (HSV-1) establishes latent infection in neurons via a variety of epigenetic mechanisms that silence its genome. The cellular CCCTC-binding factor (CTCF) functions as a mediator of transcriptional control and chromatin organization ...
Jennifer S. Lee +5 more
doaj +2 more sources
The transcriptional regulator CCCTC-binding factor limits oxidative stress in endothelial cells. [PDF]
J Biol Chem, 2018 The CCCTC-binding factor (CTCF) is a versatile transcriptional regulator required for embryogenesis, but its function in vascular development or in diseases with a vascular component is poorly understood. Here, we found that endothelial Ctcf is essential for mouse vascular development and limits accumulation of reactive oxygen species (ROS ...
Roy AR +8 more
europepmc +5 more sources