Results 41 to 50 of about 6,498 (147)

CCCTC-Binding Factor Confines the Distal Action of Estrogen Receptor [PDF]

Cancer Research, 2008
Abstract Distal enhancers have recently emerged as a common mode of gene regulation for several transcription factors, including estrogen and androgen receptors, the two key regulators of breast and prostate cancer major subtypes. Despite the rapid success in genome-wide annotation of estrogen receptor-α (ERα) binding sites in cell ...
Chang S, Chan, Jun S, Song
openaire   +2 more sources

SMURF1 Regulates CTCF-HOXA10 Axis and Promotes Tumor Progression in Nasopharyngeal Carcinoma. [PDF]

Cancer Sci
Our study showed that SMURF1 was significantly upregulated in nasopharyngeal carcinoma (NPC) and promoted tumor progression and SMURF1 promoted K48‐linked ubiquitination degradation of CTCF. ABSTRACT The aberrant upregulation of Homeobox A10 (HOXA10) has been implicated in the progression of nasopharyngeal carcinoma (NPC), but the mechanisms driving ...
Jin Y, Zhang T, Wu Z, Liang Y, Jiang Y, Yu G.   +5 more
europepmc   +2 more sources

Functional role of CCCTC binding factor (CTCF) in stress-induced apoptosis [PDF]

Experimental Cell Research, 2007
CTCF, a nuclear transcriptional factor, is a multifunctional protein and involves regulation of growth factor- and cytokine-induced cell proliferation/differentiation. In the present study, we investigated the role of CTCF in protecting stress-induced apoptosis in various human cell types.
Tie, Li, Luo, Lu
openaire   +2 more sources

Expression analysis of p50-associated COX-2 extragenic RNA and NF-Kappa B Interacting long non-coding RNA in multiple sclerosis patients

Journal of Pharmaceutical and Biomedical Analysis Open, 2023
Inflammatory long non-coding RNAs (lncRNAs) including PACER (p50-associated COX-2 extragenic RNA) and NKILA (NF-Kappa B Interacting long non-coding RNA) and have recently emerged as essential regulators in immune and inflammation pathways in patients ...
Zeinab Shirvani-Farsani, Mina Rezaei, Zahra Abedi Kichi, Mehrdad Behmanesh, Shirin Farivar   +4 more
doaj   +1 more source

CTCF, Cohesin, and Chromatin in Human Cancer [PDF]

Genomics & Informatics, 2017
It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex.
Sang-Hyun Song, Tae-You Kim
doaj   +1 more source

Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia

Cell Reports, 2023
Summary: Monoallelic inactivation of CCCTC-binding factor (CTCF) in human cancer drives altered methylated genomic states, altered CTCF occupancy at promoter and enhancer regions, and deregulated global gene expression.
Willem K. Smits, Carlo Vermeulen, Rico Hagelaar, Shunsuke Kimura, Eric M. Vroegindeweij, Jessica G.C.A.M. Buijs-Gladdines, Ellen van de Geer, Marjon J.A.M. Verstegen, Erik Splinter, Simon V. van Reijmersdal, Arjan Buijs, Niels Galjart, Winfried van Eyndhoven, Max van Min, Roland Kuiper, Patrick Kemmeren, Charles G. Mullighan, Wouter de Laat, Jules P.P. Meijerink   +18 more
doaj   +1 more source

CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair

Nature Communications, 2020
Myelination by Schwann cells (SC) in the peripheral nervous system is essential for motor function, and dysregulation of SC myelination can lead to various neuropathies.
Jincheng Wang, Jiajia Wang, Lijun Yang, Chuntao Zhao, Laiman Natalie Wu, Lingli Xu, Feng Zhang, Qinjie Weng, Michael Wegner, Q. Richard Lu   +9 more
doaj   +1 more source

Epigenetic and transcriptional analysis reveals a core transcriptional program conserved in clonal prostate cancer metastases

Molecular Oncology, 2021
The epigenomic regulation of transcriptional programs in metastatic prostate cancer is poorly understood. We studied the epigenomic landscape of prostate cancer drivers using transcriptional profiling and ChIP‐seq in four clonal metastatic tumors derived
Tesa M. Severson, Yanyun Zhu, Angelo M. De Marzo, Tracy Jones, Jonathan W. Simons, William G. Nelson, Srinivasan Yegnasubramanian, Matthew L. Freedman, Lodewyk Wessels, Andries M. Bergman, Michael C. Haffner, Wilbert Zwart   +11 more
doaj   +1 more source

Regulation of Eye Development by Transcription Control of CCCTC Binding Factor (CTCF) [PDF]

Journal of Biological Chemistry, 2004
CCCTC binding factor (CTCF), a transcriptional regulator, plays important roles in epigenetics and development. In the present study, we report that overexpression of CTCF in transgenic mice during embryonic development suppresses Pax6 gene expression. This effect causes defects in ocular development that result in microophthalmia. In eye-derived cells
Tie, Li, Zhenyu, Lu, Luo, Lu
openaire   +2 more sources

The Role of CCCTC-Binding Factor (CTCF) in Genomic Imprinting, Development, and Reproduction1

Biology of Reproduction, 2014
Mauricio Machaim Franco, Rebecca J Oakey, Prickett Adam R   +2 more
exaly   +2 more sources