Results 31 to 40 of about 5,303,548 (144)

Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia

Cell Reports, 2023
Summary: Monoallelic inactivation of CCCTC-binding factor (CTCF) in human cancer drives altered methylated genomic states, altered CTCF occupancy at promoter and enhancer regions, and deregulated global gene expression.
Willem K. Smits, Carlo Vermeulen, Rico Hagelaar, Shunsuke Kimura, Eric M. Vroegindeweij, Jessica G.C.A.M. Buijs-Gladdines, Ellen van de Geer, Marjon J.A.M. Verstegen, Erik Splinter, Simon V. van Reijmersdal, Arjan Buijs, Niels Galjart, Winfried van Eyndhoven, Max van Min, Roland Kuiper, Patrick Kemmeren, Charles G. Mullighan, Wouter de Laat, Jules P.P. Meijerink   +18 more
doaj   +1 more source

CCCTC-binding factor acts upstream of FOXA1 and demarcates the genomic response to estrogen. [PDF]

J Biol Chem, 2010
Transcription activation by estrogen receptor (ER) is rapid and dynamic. How the prompt and precise ER response is established and maintained is still not fully understood.
Zhang Y, Liang J, Li Y, Xuan C, Wang F, Wang D, Shi L, Zhang D, Shang Y.   +8 more
europepmc   +2 more sources

CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis

Genome Biology, 2018
A recent study used CRISPR/Cas9 to reveal long-range looping between disease-related genes and their regulatory elements that is mediated by the CCCTC-binding factor (CTCF) in prostate cancer.
Xiang Guo, Ann Dean
doaj   +1 more source

CTCF loss induces giant lamellar bodies in Purkinje cell dendrites

Acta Neuropathologica Communications, 2022
CCCTC-binding factor (CTCF) has a key role in higher-order chromatin architecture that is important for establishing and maintaining cell identity by controlling gene expression.
Teruyoshi Hirayama, Yuuki Kadooka, Etsuko Tarusawa, Sei Saitoh, Hisako Nakayama, Natsumi Hoshino, Soichiro Nakama, Takahiro Fukuishi, Yudai Kawanishi, Hiroki Umeshima, Koichi Tomita, Yumiko Yoshimura, Niels Galjart, Kouichi Hashimoto, Nobuhiko Ohno, Takeshi Yagi   +15 more
doaj   +1 more source

Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of Protocadherin-α gene expression [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2012
Kevin Monahan, Richard M Myers, Tom Maniatis   +2 more
exaly   +2 more sources

Variable structure motifs for transcription factor binding sites [PDF]

, 2010
Background: Classically, models of DNA-transcription factor binding sites (TFBSs) have been based on relatively few known instances and have treated them as sites of fixed length using position weight matrices (PWMs).
Evans, Kenneth J., Dyer, N., Nigel Dyer, Ott Sascha, Reid, J.E., Lorenz Wernisch, Sascha Ott, Ott, S., Wernisch Lorenz, John E Reid, Evans Kenneth J, Wernisch, Lorenz, Reid, J. E. (John E.), Kenneth J Evans, Dyer, Nigel, Dyer Nigel, Ott, Sascha, Reid John E   +17 more
core   +6 more sources

Demarcation of Topologically Associating Domains Is Uncoupled from Enriched CTCF Binding in Developing Zebrafish

iScience, 2020
Summary: CCCTC-binding factor (CTCF) is a conserved architectural protein that plays crucial roles in gene regulation and three-dimensional (3D) chromatin organization.
Yuvia A. Pérez-Rico, Emmanuel Barillot, Alena Shkumatava   +2 more
doaj   +1 more source

Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression

Nucleus, 2022
Cellular senescence provokes a dramatic alteration of chromatin organization and gene expression profile of proinflammatory factors, thereby contributing to various age-related pathologies via the senescence-associated secretory phenotype (SASP ...
Kenichi Miyata, Akiko Takahashi
doaj   +1 more source

Nuclear factor I genomic binding associates with chromatin boundaries [PDF]

, 2013
BACKGROUND: The Nuclear Factor I (NFI) family of DNA binding proteins (also called CCAAT box transcription factors or CTF) is involved in both DNA replication and gene expression regulation.
Armelle Gaussin, Schmid, Christoph D., Mermod, Nicolas, Jozef Adamcik, Ambrosini, Giovanna, Schmid, C. D., Pjanic, P., Giovanna Ambrosini, Plasari, Genta, Genta Plasari, Bucher, P., Adamcik, Jozef, Kerschgens, J., Christoph D Schmid, Petar Pjanic, Pjanic, Petar, Kerschgens, Jan, Ambrosini, G., Pjanic, Milos, Gaussin, Armelle, Gaussin, A., Pjanic, M., Philipp Bucher, Plasari, G., Jan Kerschgens, Adamcik, J., Giovani Dietler, Bucher, Philipp, Milos Pjanic, Dietler, Giovani, Dietler, G., Schmid, C.D., Nicolas Mermod, Mermod, N.   +33 more
core   +2 more sources

Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency

Molecular Brain, 2021
CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features.
Dong Il Choi, Myeongwon Kim, Somi Kim, Nam-Kyung Yu, Chuljung Kwak, Hyunhyo Seo, Kyungmin Lee, Bong-Kiun Kaang   +7 more
doaj   +1 more source