Results 31 to 40 of about 6,498 (147)

Identification of a tyrosine-phosphorylated CCCTC-binding nuclear factor in capacitated mouse spermatozoa

Proteomics, 2006
AbstractThe molecular basis of mammalian sperm capacitation, either in vivo in the female reproductive tract, or in vitro, is poorly understood. It is well known that sperm capacitation is associated with an increase in tyrosine phosphorylation of a subset of proteins. We resolved the phosphoproteins in the cell lysate of mouse sperm after capacitation
Yee-Hsiung Chen
exaly   +3 more sources

CCCTC-binding factor acts upstream of FOXA1 and demarcates the genomic response to estrogen. [PDF]

J Biol Chem, 2010
Transcription activation by estrogen receptor (ER) is rapid and dynamic. How the prompt and precise ER response is established and maintained is still not fully understood. Here, we report that two boundary elements surrounding the well defined ERalpha target TFF1 locus are occupied by the CCCTC-binding factor (CTCF). These elements are separated by 40
Zhang Y, Liang J, Li Y, Xuan C, Wang F, Wang D, Shi L, Zhang D, Shang Y.   +8 more
europepmc   +4 more sources

Molecular Mimics: How Viral Genomes Dupe Their Host by Usurping CTCF to Establish Infection [PDF]

Viruses
The eukaryotic genome is organized into distinct structural units dictated by architectural proteins. The major host architectural protein CCCTC-binding factor (CTCF) is usurped by DNA viruses to regulate viral gene expression.
Clairine I. S. Larsen, Rhiannon R. Abrahams, Kinjal Majumder   +2 more
doaj   +2 more sources

Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcription.

PLoS ONE, 2009
BackgroundOver 15 inherited diseases are caused by expansion of triplet-repeats. Friedreich ataxia (FRDA) patients are homozygous for an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene.
Irene De Biase, Yogesh K Chutake, Paul M Rindler, Sanjay I Bidichandani   +3 more
doaj   +4 more sources

One protein to rule them all: The role of CCCTC-binding factor in shaping human genome in health and disease [PDF]

Seminars in Cell and Developmental Biology, 2019
Wayne K Dawson, Dariusz Plewczynski
exaly   +2 more sources

CCCTC-Binding Factor Controls Its Own Nuclear Transport via Regulating the Expression of Importin 13 [PDF]

Molecules and Cells, 2013
Jingjing Shen, Shen Jingjing
exaly   +2 more sources

The CCCTC‐binding factor (CTCF)–forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma [PDF]

Journal of Pathology, 2017
Xiaoping Zou, Terence Kin Wah Lee, Eunice Yuen Ting Lau   +2 more
exaly   +2 more sources

CCCTC-Binding Factor Recruitment to the Early Region of the Human Papillomavirus 18 Genome Regulates Viral Oncogene Expression [PDF]

Journal of Virology, 2015
Ian J Groves, Simon J Powis, Nicholas Coleman   +2 more
exaly   +2 more sources

CTCF puts a new twist on UV damage and repair in skin cancer

Molecular & Cellular Oncology, 2021
Somatic mutations in skin cancers are highly enriched at binding sites for CCCTC-binding factor (CTCF). We have discovered that CTCF binding alters the DNA structure to render it more susceptible to UV damage. Elevated UV damage formation at CTCF binding
Bastian Stark, Gregory M. K. Poon, John J. Wyrick   +2 more
doaj   +1 more source

Cohesin-Mediated Chromatin Interactions and Autoimmunity

Frontiers in Immunology, 2022
Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions preventing premature separation of sister chromatids after DNA replication. In partnership with CCCTC-
Venkataragavan Chandrasekaran, Nina Oparina, Maria-Jose Garcia-Bonete, Caroline Wasén, Caroline Wasén, Malin C. Erlandsson, Eric Malmhäll-Bah, Karin M. E. Andersson, Maja Jensen, Sofia T. Silfverswärd, Gergely Katona, Maria I. Bokarewa, Maria I. Bokarewa   +12 more
doaj   +1 more source