Results 1 to 10 of about 24,744 (118)
DNA-Encoded Binding Affinity Shapes Robust CTCF Occupancy Across Cellular Contexts [PDF]
BiologyCCCTC-binding factor (CTCF) is an architectural protein that organizes 3D genome architecture by binding to tens of thousands of genomic loci in a typical human cell type.
Zihang Yin +4 more
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Hypoxia-Induced CTCF Promotes EMT in Breast Cancer
Cell ReportsSummary: Cancer cells experiencing hypoxic stress employ epithelial-mesenchymal transition (EMT) to undergo metastasis through rewiring of the chromatin landscape, epigenetics, and importantly, gene expression.
Deepak Pant +2 more
exaly +3 more sources
Radiology and Oncology, 2023 Non-small cell lung cancer (NSCLC) is the major pathological type of lung cancer and accounts for the majority of lung cancer-related deaths worldwide.
Tang Jiyang +3 more
doaj +1 more source
Ctcf haploinsufficiency mediates intron retention in a tissue-specific manner
RNA Biology, 2021 CTCF is a master regulator of gene transcription and chromatin organisation with occupancy at thousands of DNA target sites genome-wide. While CTCF is essential for cell survival, CTCF haploinsufficiency is associated with tumour development and ...
Adel B Alharbi +8 more
doaj +1 more source
CTCF binding protein and epigenetic regulations of genome [PDF]
مجله بیوتکنولوژی کشاورزی, 2013 CTCF is a highly conserved DNA-binding protein involved in transcription regulation, chromatin insulation, genomic imprinting, X-chromosome inactivation, higher-order chromatin organization, and alternative splicing.
Mohammad Reza Mohammad Abadi +2 more
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Loss of maternal CTCF is associated with peri-implantation lethality of Ctcf null embryos. [PDF]
PLoS ONE, 2012 CTCF is a highly conserved, multifunctional zinc finger protein involved in critical aspects of gene regulation including transcription regulation, chromatin insulation, genomic imprinting, X-chromosome inactivation, and higher order chromatin ...
James M Moore +10 more
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Cell Regeneration, 2022 The CCCTC-binding factor (CTCF) protein and its modified forms regulate gene expression and genome organization. However, information on CTCF acetylation and its biological function is still lacking. Here, we show that CTCF can be acetylated at lysine 20
Shixin Gong +7 more
doaj +1 more source
Spatial patterns of CTCF sites define the anatomy of TADs and their boundaries
Genome Biology, 2020 Background Topologically associating domains (TADs) are genomic regions of self-interaction. Additionally, it is known that TAD boundaries are enriched in CTCF binding sites.
Luca Nanni, Stefano Ceri, Colin Logie
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Modular insulators: genome wide search for composite CTCF/thyroid hormone receptor binding sites. [PDF]
PLoS ONE, 2010 The conserved 11 zinc-finger protein CTCF is involved in several transcriptional mechanisms, including insulation and enhancer blocking. We had previously identified two composite elements consisting of a CTCF and a TR binding site at the chicken ...
Oliver Weth +5 more
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Cell Reports, 2015 The role of CTCF in stabilizing long-range interactions between chromatin sites essential for maintaining nuclear architecture is well established. Most of these interactions involve recruitment of the cohesin complex to chromatin via CTCF.
Tiaojiang Xiao +3 more
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