Results 1 to 10 of about 23,786 (199)
Loss of maternal CTCF is associated with peri-implantation lethality of Ctcf null embryos. [PDF]
PLoS ONE, 2012 CTCF is a highly conserved, multifunctional zinc finger protein involved in critical aspects of gene regulation including transcription regulation, chromatin insulation, genomic imprinting, X-chromosome inactivation, and higher order chromatin ...
James M Moore +10 more
doaj +4 more sources
An upstream secondary DNA motif within the IL3 insulator CTCF binding site is required for enhancer-blocking insulator activity. [PDF]
PLoS ONECCCTC-binding Factor (CTCF) is the only known vertebrate protein that functions to organise the genome into distinct functional chromatin domains. A subset of CTCF sites also provide insulator activity and barrier activity to block inappropriate enhancer-
Sarion R Bowers, Peter N Cockerill
doaj +2 more sources
The LDB1 Complex Co-opts CTCF for Erythroid Lineage-Specific Long-Range Enhancer Interactions
Cell Reports, 2017 Summary: Lineage-specific transcription factors are critical for long-range enhancer interactions, but direct or indirect contributions of architectural proteins such as CCCTC-binding factor (CTCF) to enhancer function remain less clear. The LDB1 complex
Ann Dean, Ivan Krivega, Ryan Dale
exaly +3 more sources
Hypoxia-induced CTCF promotes EMT in breast cancer
Cell ReportsSummary: Cancer cells experiencing hypoxic stress employ epithelial-mesenchymal transition (EMT) to undergo metastasis through rewiring of the chromatin landscape, epigenetics, and importantly, gene expression.
Sanjeev Shukla, Atul Samaiya
exaly +3 more sources
Radiology and Oncology, 2023 Non-small cell lung cancer (NSCLC) is the major pathological type of lung cancer and accounts for the majority of lung cancer-related deaths worldwide.
Tang Jiyang +3 more
doaj +1 more source
Ctcf haploinsufficiency mediates intron retention in a tissue-specific manner
RNA Biology, 2021 CTCF is a master regulator of gene transcription and chromatin organisation with occupancy at thousands of DNA target sites genome-wide. While CTCF is essential for cell survival, CTCF haploinsufficiency is associated with tumour development and ...
Adel B Alharbi +8 more
doaj +1 more source
CTCF binding protein and epigenetic regulations of genome [PDF]
مجله بیوتکنولوژی کشاورزی, 2013 CTCF is a highly conserved DNA-binding protein involved in transcription regulation, chromatin insulation, genomic imprinting, X-chromosome inactivation, higher-order chromatin organization, and alternative splicing.
Mohammad Reza Mohammad Abadi +2 more
doaj +1 more source
Cell Regeneration, 2022 The CCCTC-binding factor (CTCF) protein and its modified forms regulate gene expression and genome organization. However, information on CTCF acetylation and its biological function is still lacking. Here, we show that CTCF can be acetylated at lysine 20
Shixin Gong +7 more
doaj +1 more source
Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression
Nucleus, 2022 Cellular senescence provokes a dramatic alteration of chromatin organization and gene expression profile of proinflammatory factors, thereby contributing to various age-related pathologies via the senescence-associated secretory phenotype (SASP ...
Kenichi Miyata, Akiko Takahashi
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Archives of Medical Science, 2021 Introduction The objective of this study was to explore the role of curcumin (CUR) in the control of renal cell carcinoma (RCC) as well as the molecular mechanism underlying the effect of CUR.
Fuhe Liu +7 more
doaj +1 more source