Results 1 to 10 of about 23,645 (194)

Loss of maternal CTCF is associated with peri-implantation lethality of Ctcf null embryos. [PDF]

PLoS ONE, 2012
CTCF is a highly conserved, multifunctional zinc finger protein involved in critical aspects of gene regulation including transcription regulation, chromatin insulation, genomic imprinting, X-chromosome inactivation, and higher order chromatin ...
James M Moore, Natalia A Rabaia, Leslie E Smith, Sara Fagerlie, Kay Gurley, Dmitry Loukinov, Christine M Disteche, Steven J Collins, Christopher J Kemp, Victor V Lobanenkov, Galina N Filippova   +10 more
doaj   +4 more sources

An upstream secondary DNA motif within the IL3 insulator CTCF binding site is required for enhancer-blocking insulator activity. [PDF]

PLoS ONE
CCCTC-binding Factor (CTCF) is the only known vertebrate protein that functions to organise the genome into distinct functional chromatin domains. A subset of CTCF sites also provide insulator activity and barrier activity to block inappropriate enhancer-
Sarion R Bowers, Peter N Cockerill
doaj   +2 more sources

The LDB1 Complex Co-opts CTCF for Erythroid Lineage-Specific Long-Range Enhancer Interactions

Cell Reports, 2017
Summary: Lineage-specific transcription factors are critical for long-range enhancer interactions, but direct or indirect contributions of architectural proteins such as CCCTC-binding factor (CTCF) to enhancer function remain less clear. The LDB1 complex
Ivan Krivega, Ryan K Dale, Ann Dean
exaly   +3 more sources

Hypoxia-induced CTCF promotes EMT in breast cancer

Cell Reports
Summary: Cancer cells experiencing hypoxic stress employ epithelial-mesenchymal transition (EMT) to undergo metastasis through rewiring of the chromatin landscape, epigenetics, and importantly, gene expression.
Shruti Ganesh Dhamdhere, Atul Samaiya, Sanjeev Shukla   +2 more
exaly   +3 more sources

Prominin 2 decreases cisplatin sensitivity in non-small cell lung cancer and is modulated by CTCC binding factor

Radiology and Oncology, 2023
Non-small cell lung cancer (NSCLC) is the major pathological type of lung cancer and accounts for the majority of lung cancer-related deaths worldwide.
Tang Jiyang, Shu Dejun, Fang Zhimin, Yang Gaolan   +3 more
doaj   +1 more source

Ctcf haploinsufficiency mediates intron retention in a tissue-specific manner

RNA Biology, 2021
CTCF is a master regulator of gene transcription and chromatin organisation with occupancy at thousands of DNA target sites genome-wide. While CTCF is essential for cell survival, CTCF haploinsufficiency is associated with tumour development and ...
Adel B Alharbi, Ulf Schmitz, Amy D Marshall, Darya Vanichkina, Rajini Nagarajah, Melissa Vellozzi, Justin JL Wong, Charles G Bailey, John EJ Rasko   +8 more
doaj   +1 more source

CTCF binding protein and epigenetic regulations of genome [PDF]

مجله بیوتکنولوژی کشاورزی, 2013
CTCF is a highly conserved DNA-binding protein involved in transcription regulation, chromatin insulation, genomic imprinting, X-chromosome inactivation, higher-order chromatin organization, and alternative splicing.
Mohammad Reza Mohammad Abadi, Mahmoud Amiri Roudbar, Hamide Adel doust   +2 more
doaj   +1 more source

CTCF acetylation at lysine 20 is required for the early cardiac mesoderm differentiation of embryonic stem cells

Cell Regeneration, 2022
The CCCTC-binding factor (CTCF) protein and its modified forms regulate gene expression and genome organization. However, information on CTCF acetylation and its biological function is still lacking. Here, we show that CTCF can be acetylated at lysine 20
Shixin Gong, Gongcheng Hu, Rong Guo, Jie Zhang, Yiqi Yang, Binrui Ji, Gang Li, Hongjie Yao   +7 more
doaj   +1 more source

High CTCF expression mediated by FGD5-AS1/miR-19a-3p axis is associated with immunosuppression and pancreatic cancer progression

Heliyon, 2023
The most common reason for cancer-related death globally is predicted to be pancreatic cancer (PC), one of the deadliest cancers. The CCCTC-binding factor (CTCF) regulates the three-dimensional structure of chromatin, was reported to be highly regulated ...
Yihao Liu, Wenxin Qi, Jingxin Yin, Xirui He, Songqi Duan, Haili Bao, Chen Li, Minmin Shi, Jiao Wang, Shaohua Song   +9 more
doaj   +1 more source

Spatial patterns of CTCF sites define the anatomy of TADs and their boundaries

Genome Biology, 2020
Background Topologically associating domains (TADs) are genomic regions of self-interaction. Additionally, it is known that TAD boundaries are enriched in CTCF binding sites.
Luca Nanni, Stefano Ceri, Colin Logie
doaj   +1 more source