Results 41 to 50 of about 31,777 (224)
Histone Acetylation Differentially Modulates CTCF-CTCF Loops and Intra-TAD Interactions. [PDF]
Nat CommunAbstract The cohesin complex structures the interphase genome of human cells by extruding loops and organizing topologically associating domains (TADs), yet how chromatin state regulates cohesin-chromatin interactions remains unclear.
Smith RG +9 more
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Role of CTCF in DNA damage response [PDF]
Mutation Research/Reviews in Mutation Research, 2019 CCCTC-binding factor (CTCF) is a highly conserved, ubiquitously expressed zinc finger protein. CTCF is a multifunctional protein, associated with a number of vital cellular processes such as transcriptional activation, repression, insulation, imprinting and genome organization.
Vinay Singh, Tanwar +2 more
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CTCF-mediated genome organization and leukemogenesis [PDF]
Leukemia, 2020 Recent technological advancements and genome-wide studies provide compelling evidence that dynamic chromatin interaction and three-dimensional genome organization in nuclei play an important role in regulating gene expression. Mammalian genomes consist of many small functional domains termed topologically associated domains (TADs), many of them ...
Yi Qiu, Suming Huang
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Beyond the coding genome: non-coding mutations and cancer
Frontiers in Bioscience-Landmark, 2020 Latest advancements in genomics involving individuals from different races and geographical locations has led to the identification of thousands of common as well as rare genetic variants and copy number variations (CNVs). These studies have surprisingly
Kaivalya Walavalkar, Dimple Notani
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CTCF-mediated chromatin interactions of PAX6 with RCN1 and ADAM17 genes.
, 2016 (A) Illustration of circularized chromosome conformation capture (4C) primers designs relative to HindIII restriction sites which are adjacent to CTCF binding sites 2 and 3 on PAX6 promoter.
Luo Lu (345233) +4 more
core +1 more source
Acute depletion of CTCF rewires genome-wide chromatin accessibility
Genome Biology, 2021 Background The transcription factor CTCF appears indispensable in defining topologically associated domain boundaries and maintaining chromatin loop structures within these domains, supported by numerous functional studies.
Beisi Xu +12 more
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Genomic Imprinting: CTCF Protects the Boundaries [PDF]
Current Biology, 2004 The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.
Lewis, Annabelle, Murrell, Adele
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A Novel Mechanism for CTCF in the Epigenetic Regulation of Bax in Breast Cancer Cells
Neoplasia: An International Journal for Oncology Research, 2013 We previously reported the association of elevated levels of the multifunctional transcription factor, CCCTC binding factor (CTCF), in breast cancer cells with the specific anti-apoptotic function of CTCF.
Claudia Fabiola Méndez-Catalá +10 more
doaj +1 more source
A CTCF Code for 3D Genome Architecture [PDF]
Cell, 2015 The architectural protein CTCF plays a complex role in decoding the functional output of the genome. Guo et al. now show that the orientation of a CTCF site restricts its choice of interacting partner, thus creating a code that predicts the three-dimensional organization of the genome.
Nichols, Michael H., Corces, Victor G.
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