Results 41 to 50 of about 29,893 (236)
Functional and molecular characterization of the role of CTCF in human embryonic stem cell biology. [PDF]
PLoS ONE, 2012 The CCCTC-binding factor CTCF is the only known vertebrate insulator protein and has been shown to regulate important developmental processes such as imprinting, X-chromosome inactivation and genomic architecture.
Sri Kripa Balakrishnan +3 more
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CTCF DNA-binding domain undergoes dynamic and selective protein–protein interactions
iScience, 2022 Summary: CTCF is a predominant insulator protein required for three-dimensional chromatin organization. However, the roles of its insulation of enhancers in a 3D nuclear organization have not been fully explained. Here, we found that the CTCF DNA-binding
Rong Zhou +13 more
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CTCF, Cohesin, and Chromatin in Human Cancer [PDF]
Genomics & Informatics, 2017 It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. Their dynamic interactions in three dimensions within the nucleus regulate gene transcription by changing the chromatin architecture.
Sang-Hyun Song, Tae-You Kim
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Nature Communications, 2021 Although the Drosophila genome has widespread contact domains and CTCF, it remains unclear whether CTCF-dependent domains exist in flies. Here, the authors ablate CTCF in Drosophila and find that CTCF is required to form a small fraction of all domain ...
Anjali Kaushal +16 more
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The role of CTCF in regulating nuclear organization [PDF]
The Journal of Experimental Medicine, 2008 The spatial organization of the genome is thought to play an important part in the coordination of gene regulation. New techniques have been used to identify specific long-range interactions between distal DNA sequences, revealing an ever-increasing complexity to nuclear organization.
Williams, Adam, Flavell, Richard A.
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Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Genome Biology, 2020 Background The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome organization, CCCTC-binding factor (CTCF) has been characterized as a DNA-binding protein with ...
Celestia Fang +14 more
doaj +1 more source
Identification of chromatin loops from Hi-C interaction matrices by CTCF–CTCF topology classification [PDF]
NAR Genomics and Bioinformatics, 2020 Abstract Genome-wide profiling of long-range interactions has revealed that the CCCTC-Binding factor (CTCF) often anchors chromatin loops and is enriched at boundaries of the so-called Topologically Associating Domains, which suggests that CTCF is essential in the 3D organization of chromatin.
Silvia Galan +2 more
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Widespread Expression of BORIS/CTCFL in Normal and Cancer Cells [PDF]
, 2011 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Mumin, MA +27 more
core +2 more sources
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source