Results 21 to 30 of about 29,893 (236)
CPT1A through succinylation regulates the CTCF/LINC01503‒91aa feedback loop to promote gemcitabine resistance in pancreatic ductal adenocarcinoma. [PDF]
Clin Transl MedLINC01503 encoded a 91‐amino acid protein named 1503‒91aa, which enhanced carnitine palmitoyl transferase 1A (CPT1A) activity and regulated fatty acid oxidation (FAO) by competitively binding to malonyl‐CoA. Meanwhile, we found a positive feedback loop whereby CPT1A acts as a succinyltransferase to stabilise CTCF (a transcription factor driving ...
Fang DL +8 more
europepmc +2 more sources
Current Opinion in Genetics & Development, 2020 CTCF plays a key role in organizing chromatin into TAD structures but it can also function as a transcription factor. CTCFL (CTCF-like), the paralog of CTCF, is normally transiently expressed in pre-meiotic male germ cells together with ubiquitously expressed CTCF.
Roxanne E, Debaugny, Jane A, Skok
openaire +3 more sources
CTCF: Master Weaver of the Genome [PDF]
Cell, 2009 CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation. Here we re-evaluate data supporting these roles in the context of mechanistic insights provided by recent genome-wide studies and highlight evidence for CTCF ...
Phillips, Jennifer E., Corces, Victor G.
openaire +2 more sources
CTCF: making the right connections [PDF]
Genes & Development, 2016 The role of the zinc finger protein CTCF in organizing the genome within the nucleus is now well established. Widely separated sites on DNA, occupied by both CTCF and the cohesin complex, make physical contacts that create large loop domains. Additional contacts between loci within those domains, often also mediated by CTCF, tend to be favored over ...
Ghirlando, Rodolfo, Felsenfeld, Gary
openaire +2 more sources
CTCF: an R/bioconductor data package of human and mouse CTCF binding sites
Bioinformatics Advances, 2022 Abstract Summary CTCF (CCCTC-binding factor) is an 11-zinc-finger DNA binding protein which regulates much of the eukaryotic genome’s 3D structure and function. The diversity of CTCF binding motifs has led to a fragmented landscape of CTCF binding data.
Mikhail G Dozmorov +6 more
openaire +2 more sources
Epigenetics, 2021 DNA hypermethylation events occur frequently in human cancers, but less is known of the mechanisms leading to their initiation. Retinoblastoma, an intraocular cancer affecting young children, involves bi-allelic inactivation of the RB1 gene (RB−/-).
AM Raizis +5 more
doaj +1 more source
CTCF terminal segments are unstructured [PDF]
Protein Science, 2010 AbstractThe human CCCTC‐binding factor, CTCF, organizes and regulates transcription of the genome by colocalizing distant DNA elements on the same and even different chromosomes. This protein consists of 11 zinc fingers flanked by polypeptide segments of unknown structure and function.
Selena R, Martinez, Jj L, Miranda
openaire +2 more sources
Beyond the coding genome: non-coding mutations and cancer
Frontiers in Bioscience-Landmark, 2020 Latest advancements in genomics involving individuals from different races and geographical locations has led to the identification of thousands of common as well as rare genetic variants and copy number variations (CNVs). These studies have surprisingly
Kaivalya Walavalkar, Dimple Notani
doaj +1 more source
Epigenetics, 2019 DNA hydroxymethylation has gained attention as an intermediate in the process of DNA demethylation. More recently, 5-hydroxymethylcytosine has been recognized as an independent epigenetic mark that can persist over time and that exerts influence on gene ...
Benjamin V. Becker +5 more
doaj +1 more source
CTCF-less active TSS and poised promoter states shared across tissues.
, 2023 Intersection plots showing number of segments annotated as (A) CTCF-less active TSS state (state 3) and (B) poised promoter state (state 1) unique to each tissue and shared across tissues. Top: bar plot indicates sizes of each intersection; Bottom right:
Carrie J. Finno (8501349) +7 more
core +1 more source