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Current Opinion in Genetics & Development, 2020 CTCF plays a key role in organizing chromatin into TAD structures but it can also function as a transcription factor. CTCFL (CTCF-like), the paralog of CTCF, is normally transiently expressed in pre-meiotic male germ cells together with ubiquitously expressed CTCF.
Roxanne E, Debaugny, Jane A, Skok
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CTCF: Master Weaver of the Genome [PDF]
Cell, 2009 CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation. Here we re-evaluate data supporting these roles in the context of mechanistic insights provided by recent genome-wide studies and highlight evidence for CTCF ...
Phillips, Jennifer E., Corces, Victor G.
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CTCF terminal segments are unstructured [PDF]
Protein Science, 2010 AbstractThe human CCCTC‐binding factor, CTCF, organizes and regulates transcription of the genome by colocalizing distant DNA elements on the same and even different chromosomes. This protein consists of 11 zinc fingers flanked by polypeptide segments of unknown structure and function.
Selena R, Martinez, Jj L, Miranda
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CTCF: an R/bioconductor data package of human and mouse CTCF binding sites
Bioinformatics Advances, 2022 Abstract Summary CTCF (CCCTC-binding factor) is an 11-zinc-finger DNA binding protein which regulates much of the eukaryotic genome’s 3D structure and function. The diversity of CTCF binding motifs has led to a fragmented landscape of CTCF binding data.
Mikhail G Dozmorov +6 more
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Identification of chromatin loops from Hi-C interaction matrices by CTCF–CTCF topology classification [PDF]
NAR Genomics and Bioinformatics, 2020 Abstract Genome-wide profiling of long-range interactions has revealed that the CCCTC-Binding factor (CTCF) often anchors chromatin loops and is enriched at boundaries of the so-called Topologically Associating Domains, which suggests that CTCF is essential in the 3D organization of chromatin.
Silvia Galan +2 more
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CTCF: making the right connections [PDF]
Genes & Development, 2016 The role of the zinc finger protein CTCF in organizing the genome within the nucleus is now well established. Widely separated sites on DNA, occupied by both CTCF and the cohesin complex, make physical contacts that create large loop domains. Additional contacts between loci within those domains, often also mediated by CTCF, tend to be favored over ...
Ghirlando, Rodolfo, Felsenfeld, Gary
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CTCF-less active TSS and poised promoter states shared across tissues.
, 2023 Intersection plots showing number of segments annotated as (A) CTCF-less active TSS state (state 3) and (B) poised promoter state (state 1) unique to each tissue and shared across tissues. Top: bar plot indicates sizes of each intersection; Bottom right:
Carrie J. Finno (8501349) +7 more
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Epigenetics, 2019 DNA hydroxymethylation has gained attention as an intermediate in the process of DNA demethylation. More recently, 5-hydroxymethylcytosine has been recognized as an independent epigenetic mark that can persist over time and that exerts influence on gene ...
Benjamin V. Becker +5 more
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Auxin-inducible degron 2 system deciphers functions of CTCF domains in transcriptional regulation
Genome Biology, 2023 Background CTCF is a well-established chromatin architectural protein that also plays various roles in transcriptional regulation. While CTCF biology has been extensively studied, how the domains of CTCF function to regulate transcription remains unknown.
Judith Hyle +6 more
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Epigenetics, 2018 DNA methylation can affect tissue-specific gene transcription in ways that are difficult to discern from studies focused on genome-wide analyses of differentially methylated regions (DMRs). To elucidate the variety of associations between differentiation-
Carl Baribault +5 more
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