Results 21 to 30 of about 23,786 (199)
CTCF: an R/bioconductor data package of human and mouse CTCF binding sites
Bioinformatics Advances, 2022 Abstract Summary CTCF (CCCTC-binding factor) is an 11-zinc-finger DNA binding protein which regulates much of the eukaryotic genome’s 3D structure and function. The diversity of CTCF binding motifs has led to a fragmented landscape of CTCF binding data.
Mikhail G Dozmorov +6 more
openaire +2 more sources
Identification of chromatin loops from Hi-C interaction matrices by CTCF–CTCF topology classification [PDF]
NAR Genomics and Bioinformatics, 2020 Abstract Genome-wide profiling of long-range interactions has revealed that the CCCTC-Binding factor (CTCF) often anchors chromatin loops and is enriched at boundaries of the so-called Topologically Associating Domains, which suggests that CTCF is essential in the 3D organization of chromatin.
Silvia Galan +2 more
openaire +2 more sources
Epigenetics, 2021 DNA hypermethylation events occur frequently in human cancers, but less is known of the mechanisms leading to their initiation. Retinoblastoma, an intraocular cancer affecting young children, involves bi-allelic inactivation of the RB1 gene (RB−/-).
AM Raizis +5 more
doaj +1 more source
CTCF: making the right connections [PDF]
Genes & Development, 2016 The role of the zinc finger protein CTCF in organizing the genome within the nucleus is now well established. Widely separated sites on DNA, occupied by both CTCF and the cohesin complex, make physical contacts that create large loop domains. Additional contacts between loci within those domains, often also mediated by CTCF, tend to be favored over ...
Ghirlando, Rodolfo, Felsenfeld, Gary
openaire +2 more sources
Beyond the coding genome: non-coding mutations and cancer
Frontiers in Bioscience-Landmark, 2020 Latest advancements in genomics involving individuals from different races and geographical locations has led to the identification of thousands of common as well as rare genetic variants and copy number variations (CNVs). These studies have surprisingly
Kaivalya Walavalkar, Dimple Notani
doaj +1 more source
Epigenetics, 2019 DNA hydroxymethylation has gained attention as an intermediate in the process of DNA demethylation. More recently, 5-hydroxymethylcytosine has been recognized as an independent epigenetic mark that can persist over time and that exerts influence on gene ...
Benjamin V. Becker +5 more
doaj +1 more source
Cell Reports, 2015 The role of CTCF in stabilizing long-range interactions between chromatin sites essential for maintaining nuclear architecture is well established. Most of these interactions involve recruitment of the cohesin complex to chromatin via CTCF.
Tiaojiang Xiao +3 more
doaj +1 more source
Epigenetics, 2018 DNA methylation can affect tissue-specific gene transcription in ways that are difficult to discern from studies focused on genome-wide analyses of differentially methylated regions (DMRs). To elucidate the variety of associations between differentiation-
Carl Baribault +5 more
doaj +1 more source
Journal of Hepatocellular Carcinoma, 2021 Haoming Mai,* Haisheng Xie,* Jia Hou,* Haitao Chen, Bin Zhou, Jinlin Hou, Deke Jiang State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Guangdong Institute of Liver Diseases, Department of ...
Mai H +6 more
doaj
CTCF as a boundary factor for cohesin-mediated loop extrusion: evidence for a multi-step mechanism
Nucleus, 2020 Mammalian genome structure is closely linked to function. At the scale of kilobases to megabases, CTCF and cohesin organize the genome into chromatin loops.
Anders S. Hansen
doaj +1 more source